摘要
以香紫苏醇为原料,经高锰酸钾氧化制备香紫苏内酯;另外,以香紫苏醇为原料,经高锰酸钾氧化和四氢铝锂还原制备降龙涎二醇。2种产物均经红外光谱、核磁共振氢谱和碳谱等进行了表征。主要探讨了氧化剂高锰酸钾用量对制备香紫苏内酯和降龙涎二醇的影响。结果表明,当n(香紫苏醇)∶n(KMnO4)=1∶5.6,反应温度为25~30℃,反应时间为5 h时,香紫苏内酯和降龙涎二醇的收率最高,分别为38.0%和22.5%。
Sclareolide was synthesized via potassium permanganate oxidation with sclareol as starting material.Besides,ambradiol was synthesized via potassium permanganate oxidation with sclareol as starting material and followed by lithium aluminum hydride reduction. Both the two products were characterized by IR,1HNMR and 13 CNMR. Effect of KMnO4 dosage on the preparation of sclareolide and ambradiol was examined. Results showed that,based on 25 ~ 30 ℃ of reaction temperature for 5 h,when potassium permanganate dosage is n( sclareol) ∶ n( KMn O4) = 1∶ 5. 6,yield of sclaeolide achieves 38. 0% and that of ambradiol achieves 22. 5%.
引文
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