通神复脑丸对脑小血管病性认知功能障碍患者同型半胱氨酸水平的影响
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摘要
目的观察通神复脑丸对脑小血管病性认知功能障碍患者同型半胱氨酸水平的影响,探讨通神复脑丸治疗脑小血管病性认知功能障碍的机制,为临床运用通神复脑丸治疗脑小血管病性认知功能障碍提供客观依据。方法选取"通神复脑丸对脑小血管病性认知功能障碍的影响"实验中同型半胱氨酸水平增高的106例患者为研究对象,其中治疗组55例,对照组51例,对治疗前后Mo CA评分及血浆同型半胱氨酸的变化进行统计学分析。结果治疗前2组患者的Mo CA评分及同型半胱氨酸水平间差异无统计学意义(P>0.05),治疗后2组患者的Mo CA评分及同型半胱氨酸水平间差异有统计学意义(P<0.05),治疗组Mo CA评分改善优于对照组。结论通神复脑丸能降低脑小血管病性认知功能障碍患者的同型半胱氨酸水平,提高其Mo CA评分,降低同型半胱氨酸水平可能是通神复脑丸改善脑小血管病性认知功能障碍的机制之一。
Objective To observe the clinical therapeutic effect of Tongshen Funao pill on homocysteine level in patients with cerebral small vessel cognitive impairment, to explore the mechanism of Tongshen Funao pill in treating cognitive impairment of patients with cerebral small vessel diseases and to provide the objective evidence for the clinical application of Tongshen Funao pill in treatment of cognitive impairment of patients with cerebral small vessel diseases. Methods In the research of " Investigation of Tongshen Funao pill in the Treatment of Cognitive Impairment in Cerebral Small Vessel Disease", there were 106 cases of patients with elevated homocysteine levels, with treatmant group of 55 and control group of 51. Before and after treatment, Mo CA score and plasma homocysteine levels were statistically analyzed. Results There was no significant difference in Mo CA score and homocysteine levels between the two groups before treatment(P>0.05), But after treatment, and the difference was significant( P < 0. 05). The Mo CA score improvement in the treatment group was better than that in the control group. Conclusion Tongshen Funao pill can improve Mo CA score, and reduce the level of homocysteine in patients with cerebral small vessel cognitive impairment. Lowering homocysteine level may be one of the mechanisms to improve cognitive impairment of cerebral small vessel diseases.
Objective To observe the clinical therapeutic effect of Tongshen Funao pill on homocysteine level in patients with cerebral small vessel cognitive impairment, to explore the mechanism of Tongshen Funao pill in treating cognitive impairment of patients with cerebral small vessel diseases and to provide the objective evidence for the clinical application of Tongshen Funao pill in treatment of cognitive impairment of patients with cerebral small vessel diseases. Methods In the research of " Investigation of Tongshen Funao pill in the Treatment of Cognitive Impairment in Cerebral Small Vessel Disease", there were 106 cases of patients with elevated homocysteine levels, with treatmant group of 55 and control group of 51. Before and after treatment, Mo CA score and plasma homocysteine levels were statistically analyzed. Results There was no significant difference in Mo CA score and homocysteine levels between the two groups before treatment(P>0.05), But after treatment, and the difference was significant( P < 0. 05). The Mo CA score improvement in the treatment group was better than that in the control group. Conclusion Tongshen Funao pill can improve Mo CA score, and reduce the level of homocysteine in patients with cerebral small vessel cognitive impairment. Lowering homocysteine level may be one of the mechanisms to improve cognitive impairment of cerebral small vessel diseases.
引文
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[2]Moran C,Phan TG,Srikanth VK.Cerebral small vessel disease:a review of clinical,radiological,and histopathological phenotypes.Int J Stroke,2012,7:36-46.
[3]Pantoni L.Cerebral small vessel disease:from pathogenesis and clinical characteristics to therapeutic challenges.Lancet Neurol,2010,9(7):689-701.
[4]Narayan SK,Saxby BK,Firbank MJ,et al.Plasma homocysteine and cognitive decline in older hypertensive subjects[J].Int Psychogeriatr,2011,23(10):1607-1615.
[5]Kim G,Kim H,Kim KN,et al.Relationship of cognitive function with B Vitamin status,homocysteine,and tissue factor pathway inhibitor in cognitively impaired elderly:a cross-sectional survey[J].JAD,2013,33(3):853-862.
[6]中华医学会神经病学分会痴呆与认知障碍学组写作组.血管性认知障碍诊治指南[J].中华神经科杂志,2011,44(2):142-147.
[7]Zhang AJ,Yu XJ,Wang M.The clinical manifestations and pathophysiology of cerebral small vessel disease[J].Neurosci Bull,2010,26(3):257-264.
[8]Staekenborg SS,van Straaten EC,van der Flier WM,et al.Small vessel versus large vessel vascular dementia:risk factors and MRI findings[J].J Neurol,2008,255(11):1644-1651.
[9]Erkinjuntti T.Subcortical vascular dementia[J].Cerebrovasc Dis,2002,13Suppl 2:58-60.
[10]Ross GW,Petrovitch H,White LR,et al.Characterizationof risk factors for vascular dementia:the Honolulu-Asia aging study[J].Neurology,1999,53(2):337-343.
[11]陈戎,刘吉昌,何剑锋,等.金纳多对轻中度血管性痴呆患者APOE、HCY及认知功能的影响[J].海南医学院学报,2011,17(11):1468-1475.
[12]张学文.中风痴呆证治探讨[J].中国中医药信息杂志,2000,7(11):1-2.
[13]王本祥.现代中药药理学[M].天津.科学技术出版社,1997:1293,1306-1307,1353-1354,891-892,909-910,412.
[14]彭延古,李露丹,邓亦辉.僵蚕抗实验性静脉血栓及作用机理的研究[J].血栓与止血学,2011,7(3):104-105.
[15]雷载权,张廷模.中华临床中药学[M].北京:人民卫生出版社,1997:1613-1614,1106.
[16]马丽焱,王春兰,张琪,等.三七皂甙对脑组织血液供应和能量代谢的影响[J].中国药理学通报,1998,14(11):27-29.
[17]牛兴荣.天麻素治疗后循环缺血性眩晕的临床观察[J].中国实用神经疾病杂志,2009,12(24):57-58.
[18]李云霞,高春华.中药羌活化学成分及药理作用研究进展[J].辽宁中医学院报,2004,6(1):22-23.
[19]彭延古,徐爱良,黄莺,等.全蝎纯化液对静脉血栓形成大鼠纤溶和凝血系统的影响[J].中国中医药信息杂志,2011,18(3):47-48.
[20]孙毅,黄世龙,邵妤,等.蜈蚣提取物抗血栓作用的研究进展[J].西北药学杂志,2012,27(3):272-273.