芜湖地区女性在妊娠各期甲状腺功能参考值调查
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摘要
目的分析芜湖地区健康女性妊娠期甲状腺变化,建立妊娠早、中、晚三期甲状腺功能的参考范围。方法选取妊娠早、中、晚期女性共计379例,采用化学发光免疫分析法分期检测TSH、FT3和FT4。另选取118例健康非妊娠女性作为对照组,分析TSH、FT3、FT4三项指标在各组之间的差异。结果血清TSH、FT3、FT4在妊娠早期的参考范围分别为0.38～4.07mIU/L、3.55～5.30pmol/L、11.35～17.43pmol/L;妊娠中期的参考范围分别为0.41～4.14mIU/L、2.99～5.20pmol/L、10.48～17.79pmol/L;妊娠晚期的参考范围分别为0.54～4.54mIU/L、2.88～4.86pmol/L、9.27～16.47pmol/L。结论芜湖地区健康妊娠期孕妇甲状腺主要血清学指标在不同孕期存在明显差异,应建立不同孕期的参考范围。
Objective To establish the reference range of thyroid hormone at different stages of pregnancy,we analyzed the serum levels of major thyroid markers in healthy women in Wuhu area during pregnancy.Methods A total of 379 women during the different pregnancy were selected to detect TSH,FT3 and FT4 by Chemiluminescence Immunoassay. Another 118 healthy non-pregnant women were selected as control group.Analysis of TSH,FT3,FT4 three indicators in the different stages. Results Serum TSH,FT3,FT4 in the early pregnancy of the reference range were 0.38～4.07 mIU/L,3.55～ 5.30 pmol/L,11.35～17.43 pmol/L. The reference range in the middle of pregnancy was 0.41～4.14 m IU/L,2.99～5.20 pmol/L,10.48～17.79 pmol/L. In the late pregnancy reference range were 0.54～4.54 mIU/L,2.88～4.86 pmol/L,9.27～16.47 pmol/L.Conclusion The main serological indexes of thyroid in healthy pregnant women in Wuhu area were significantly different at different gestational periods,and we should establish a reference range for different pregnancies.
Objective To establish the reference range of thyroid hormone at different stages of pregnancy,we analyzed the serum levels of major thyroid markers in healthy women in Wuhu area during pregnancy.Methods A total of 379 women during the different pregnancy were selected to detect TSH,FT3 and FT4 by Chemiluminescence Immunoassay. Another 118 healthy non-pregnant women were selected as control group.Analysis of TSH,FT3,FT4 three indicators in the different stages. Results Serum TSH,FT3,FT4 in the early pregnancy of the reference range were 0.38～4.07 mIU/L,3.55～ 5.30 pmol/L,11.35～17.43 pmol/L. The reference range in the middle of pregnancy was 0.41～4.14 m IU/L,2.99～5.20 pmol/L,10.48～17.79 pmol/L. In the late pregnancy reference range were 0.54～4.54 mIU/L,2.88～4.86 pmol/L,9.27～16.47 pmol/L.Conclusion The main serological indexes of thyroid in healthy pregnant women in Wuhu area were significantly different at different gestational periods,and we should establish a reference range for different pregnancies.
引文
1 Papendieck P,Chiesa A,Prieto L,et al.Thyroid disorders of neonatesborn to mothers with Graves'disease[J].J Pediatr Endocrinol Metab,2009,22(6):547-553.
2 Phoojaroenchanachai M,Sriussadaporn S,Peerapatdit T,et al.Effect of maternalhyperthyroidism during late pregnancy on the risk of neonatal low birth weight[J].Clin Endocrinol(Oxf),2001,54(3):365-370.
3 Haddow J E,Palomaki G E,Allan WC,et al.Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child[J].N Engl J Med,1999,341(8):549-555.
4 Shan Z Y,Chen Y Y,Teng W P,et al.A study for maternal thyroid hormone deficiency during the first half of pregnancy in China[J].Eur J Clin Invest,2009,39(1):37-42.
5 Su P Y,Huang K,Hao J H,et al.Maternal thyroid function in the first twenty weeks of pregnancy and subsequent fetal and infant development:A prospective population-based cohort study in China[J].J Clin Endocirnol Metab,2011,96(10):3234-3241.
6中华医学会内分泌学会,中华医学会围产医学分会.妊娠和产后甲状腺疾病诊治指南[J].中华内分泌代谢杂志,2012,28(5):354-371.
7王淑珍,刘杰,林丽娅.建立该地区妊娠各期甲状腺激素参考范围及甲状腺激素变化的探讨[J].病理研究,2016,35(12):61-63.68.
8杨小猛,赵丹,陈书恩,等.正常孕妇妊娠各期甲状腺激素参考范围的建立及其临床意义[J].分子诊断与治疗杂志,2014,6(1):33-36.
9罗军,韩密,宋梦帆,等.两种免疫试剂检测妊娠期甲状腺功能结果的比较[J].中华围产医学杂志,2012,15(7):404-410.
10薛海波,李元宾,滕卫平,等.妊娠早期母亲亚临床甲状腺功能减退症对其后代脑发育影响的前瞻性研究[J].中华内分泌代谢杂志,2010,26(11):135-137.
11申妍,左常婷.济南地区正常妊娠妇女甲状腺功能指标的参考范围评估[J].山东大学学报(医学版),2016,54(5):34-38.
2 Phoojaroenchanachai M,Sriussadaporn S,Peerapatdit T,et al.Effect of maternalhyperthyroidism during late pregnancy on the risk of neonatal low birth weight[J].Clin Endocrinol(Oxf),2001,54(3):365-370.
3 Haddow J E,Palomaki G E,Allan WC,et al.Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child[J].N Engl J Med,1999,341(8):549-555.
4 Shan Z Y,Chen Y Y,Teng W P,et al.A study for maternal thyroid hormone deficiency during the first half of pregnancy in China[J].Eur J Clin Invest,2009,39(1):37-42.
5 Su P Y,Huang K,Hao J H,et al.Maternal thyroid function in the first twenty weeks of pregnancy and subsequent fetal and infant development:A prospective population-based cohort study in China[J].J Clin Endocirnol Metab,2011,96(10):3234-3241.
6中华医学会内分泌学会,中华医学会围产医学分会.妊娠和产后甲状腺疾病诊治指南[J].中华内分泌代谢杂志,2012,28(5):354-371.
7王淑珍,刘杰,林丽娅.建立该地区妊娠各期甲状腺激素参考范围及甲状腺激素变化的探讨[J].病理研究,2016,35(12):61-63.68.
8杨小猛,赵丹,陈书恩,等.正常孕妇妊娠各期甲状腺激素参考范围的建立及其临床意义[J].分子诊断与治疗杂志,2014,6(1):33-36.
9罗军,韩密,宋梦帆,等.两种免疫试剂检测妊娠期甲状腺功能结果的比较[J].中华围产医学杂志,2012,15(7):404-410.
10薛海波,李元宾,滕卫平,等.妊娠早期母亲亚临床甲状腺功能减退症对其后代脑发育影响的前瞻性研究[J].中华内分泌代谢杂志,2010,26(11):135-137.
11申妍,左常婷.济南地区正常妊娠妇女甲状腺功能指标的参考范围评估[J].山东大学学报(医学版),2016,54(5):34-38.