miRNA在几种动物应激中的研究进展
|
摘要
miRNA是一类内源性18～22个核苷酸的非编码小RNA分子,通过与靶mRNA的3′非翻译区(3′untran-slated region,UTR)结合来调节基因的表达。在动物的多种生理进程和疾病的发生发展中,miRNA均发挥着重要作用。应激是机体对外界环境变化而产生的一系列非特异性的应答反应,不同应激源的刺激会导致miRNA的表达发生改变。因此,探究miRNA在动物应激中的研究进展对畜牧业的发展具有重要意义。本文综述了应激相关miRNA的研究进展,以期从分子水平寻找预防和诊断动物应激的方案。
MiRNAs are a class of endogenous,18 ～ 22 nucleotides,small non-coding RNAs,which regulate the expression of genes through binding to the 3′ untranslated region(UTR)of target mRNA. Besides,miRNA plays an important role in the development of numerous physiological processes and diseases of animals. Stress is the non-specific response of body coping with sudden environmental changes. The expression of miRNA can be modified by stimulation of different stressors. Thus,exploring the progress in research on the role of miRNA in animal stress is of a great significance in the development of animal husbandry. This paper reviewed the research progress of stress-related miRNAs in order to find the solutions to prevent and diagnose animal stress at molecular level.
MiRNAs are a class of endogenous,18 ～ 22 nucleotides,small non-coding RNAs,which regulate the expression of genes through binding to the 3′ untranslated region(UTR)of target mRNA. Besides,miRNA plays an important role in the development of numerous physiological processes and diseases of animals. Stress is the non-specific response of body coping with sudden environmental changes. The expression of miRNA can be modified by stimulation of different stressors. Thus,exploring the progress in research on the role of miRNA in animal stress is of a great significance in the development of animal husbandry. This paper reviewed the research progress of stress-related miRNAs in order to find the solutions to prevent and diagnose animal stress at molecular level.
引文
[1] GUO W J,ZHEN L,ZHANG J X,et al. Effect of acute cold stress on miRNA in rat liver[J]. Chin Journal of Veter Sci,2016,36(9):1582-1585.(in Chinese)郭文晋,甄莉,张婧馨,等.急性冷应激对大鼠肝脏miRNA的影响[J].中国兽医学报,2016,36(9):1582-1585.
[2] CAULFIELD M P,CAMBRIDGE H,FOSTER S F,et al. Heat stress:a major contributor to poor animal welfare associated with long-haul live export voyages[J]. Veter J,2014,199(2):223-228.
[3] WANG G G,WU X,MENG Q X,et al. Research progress on effect of transport stress on ruminants body function and meat quality[J]. Chin Animal Husbandry&Veter Med,2017,44(3):755-760.(in Chinese)王国艮,吴鑫,孟庆翔,等.运输应激对反刍动物机体功能及肉品质影响的研究进展[J].中国畜牧兽医,2017,44(3):755-760.
[4] ISLAM M T. Oxidative stress and mitochondrial dysfunctionlinked neurodegenerative disorders[J]. Neurol Res,2017,39(1):73-82.
[5] NYAYANIT D,GADGIL C J. Mathematical modeling of combinatorial regulation suggests that apparent positive regulation of targets by miRNA could be an artifact resulting from competition for m RNA[J]. RNA,2015,21(3):307-319.
[6] ZHANG N,WEI X,XU L. miR-150 promotes the proliferation of lung cancer cells by targeting P53[J]. Febs Lett,2013,587(15):2346-2351.
[7] SIENGDEE P,TRAKOOLJUL N,MURANI E,et al. MicroRNAs regulate cellular ATP levels by targeting mitochondrial energy metabolism genes during C2C12 myoblast differentiation[J]. Plos One,2015,10(5):e0127850.
[8] NEUTELINGS T,LAMBERT C A,NUSGENS B V,et al. Effects of mild cold shock(25℃)followed by warming up at 37℃on the cellular stress response[J]. Plos One,2013,8(7):e69687.
[9] LIAN S,GUO J,WANG L,et al. Impact of prenatal cold stress on placental physiology,inflammatory response,and apoptosis in rats[J]. Oncotarget,2017,8(70):115304-115314.
[10] ZHAO F Q,ZHANG Z W,YAO H D,et al. Effects of cold stress on m RNA expression of immunoglobulin and cytokine in the small intestine of broilers[J]. Res Veter Sci,2013,95(1):146-155.
[11] GUO W,LIAN S,ZHEN L,et al. The favored mechanism for coping with acute cold stress:upregulation of miR-210 in rats[J]. Cell Physiol Biochem,2018,46(5):2090-2102.
[12] LIAN S,WANG D,XU B,et al. Prenatal cold stress:effect on maternal hippocampus and offspring behavior in rats[J].Behav Brain Res,2018,346:1-10.
[13] PENG M L,YANG H M,LIU Y Z,et al. Progress in study on serum mi RNAs as biomarkers of diseases[J]. Chin J Biologicals,2015,28(9):985-988.(in Chinese)彭梦玲,杨焕民,刘艳芝,等.疾病相关生物标志物-血清miRNAs的研究进展[J].中国生物制品学杂志,2015,28(9):985-988.
[14] LI Z,GUO W,PENG M,et al. Identification of cold-responsive miRNAs in rats by deep sequencing[J]. J Thermal Biol,2017,66:114-124.
[15]臧树成,郭文晋,甄莉,等.急性冷应激对大鼠肝脏中novel miRNA的影响[C].中国生理学会内分泌代谢、比较生理与应激生理学术会议.辽宁沈阳,2017.
[16] YIN K,ZHAO L,FENG D,et al. Resveratrol attenuated low ambient temperature-induced myocardial hypertrophy via inhibiting cardiomyocyte apoptosis[J]. Cell Physiol&Biochem,2015,35(6):2451-2462.
[17] T AO C,HUAN G S,WANG Y,et al. Changes in white and brown adipose tissue microRNA expression in cold-induced mice[J]. Biochem&Biophys Res Commun,2015,463(3):193-199.
[18] PENG X K,HU J H,ZHANG E P. Effects of heat stress on physiological and biochemical indexes and expression levels of miRNA in peripheral blood of beef cattle,sheep and goats[J].J Domestic Animal Ecol,2018,39(3):1-7.彭孝坤,胡建宏,张恩平.热应激对肉牛和肉羊生理生化指标及外周血miRNA表达水平的影响[J].家畜生态学报,2018,39(3):1-7..
[19] ZHENG Y,CHEN K L,LI H X,et al. Profiling of differential expression of microRNAs in serum of heat-stresseded cows and bioinformatic analyses of miR-181a target genes[J]. J Nanjing Agr Univ,2014,37(6):130-136.郑月,陈坤琳,李惠侠,等.热应激奶牛血清miRNA表达谱及miR-181a靶基因分析[J].南京农业大学学报,2014,37(6):130-136.
[20] HU Y,CAI M C,WANG L,et al. The serum biochemical indexes and miRNA expression in cattle under heat stress and their correlation analysis[J]. Chin J Animal Veter Sci 2016,47(9):1840-1847.胡煜,蔡明成,王玲,等.热应激状态下牛血清生化指标、miRNA表达变化及其相关性分析[J].畜牧兽医学报,2016,47(9):1840-1847.
[21] GUO X,CHI S,XIA C,et al. Baicalin protects sertoli cells from heat stress-induced apoptosis via activation of the Fas/FasL pathway and Hsp72 expression[J]. Reprod Toxicol,2015,57(1):196-203.
[22] CHEN H,WANG J,HU B,et al. MiR-34a promotes Fas-mediated cartilage endplate chondrocyte apoptosis by targeting Bcl-2[J]. Mol&Cell Biochem,2015,406(1-2):21-30.
[23] ZHANG J F,SHI L L,ZHANG L,et al. MicroRNA-25 negatively regulates cerebral ischemia/reperfusion injury-induced cell apoptosis through Fas/FasL pathway[J]. J Mol Neurosci,2016,58(4):507-516.
[24] CAI M,HU Y,ZHENG T,et al. MicroRNA-216b inhibits heat stress-induced cell apoptosis by targeting Fas in bovine mammary epithelial cells[J]. Cell Stress&Chaperones,2018,5(23):921-931.
[25] SOHAL R S,ALLEN R G,FARMER K J,et al. Iron induces oxidative stress and may alter the rate of aging in the housefly,Musca domestica[J]. Mechanisms Ageing&Develop,1985,32(1):33-88.
[26] CUI. Y J. Effects of heat stress and oxidative stress on metabolism of skeletal muscle and protection of lipoic acid in finishing pigs[D]. Beijing:Chinese Academy of Agricultural Sciences,2016.崔艳军.热应激和氧化应激对肥育猪骨骼肌代谢的影响及硫辛酸的调控作用[D].北京:中国农业科学院,2016.
[27] MA Y F,SONG L W,GAO M,et al. Effect of oxidative stress on transition dairy cow mastitis and its regulation mechanisms[J]. Chin J Animal Nutrit,2015,27(3):671-676.马燕芬,宋利文,高民,等.氧化应激对围产期奶牛乳房炎的影响及其调控机制[J].动物营养学报,2015,27(3):671-676.
[28] SA R L,YANG B,AO C J. Research progress of natural plant extracts in animal oxidative stress[J]. Chin J Animal Nutrit,2018,30(6):2021-2026.萨茹丽,杨斌,敖长金.天然植物提取物在动物氧化应激中的研究概况[J].动物营养学报,2018,30(6):2021-2026.
[29] RUDOV A,BALDUINI W,CARLONI S,et al. Involvement of mi RNAs in placental alterations mediated by oxidative stress[J].Oxidative Med&Cell Longevity,2014,2014(1):103068.
[30] L C,V D S,E I,et al. Hypoxia-inducible factor 1-αinduces miR-210 in normoxic differentiating myoblasts[J]. J Biological Chem,2012,287(53):44761-44771.
[31] CHEN Z,WEN L,MARTIN M,et al. Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2(SREBP2)transactivation of MiRNA-92a[J].Circulation,2015,131(9):805-814.
[32] SANGOKOYA C,TELEN M J,CHI J T. microRNA miR-144modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease[J]. Blood,2010,116(20):4338-4348.
[33] YU D,DOS SANTOS C O,ZHAO G,et al. miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta[J].Genes&Develop,2010,24(15):1620-1633.
[34] HU Y,LI P,HAO S,et al. Differential expression of microRNAs in the placentae of Chinese patients with severe preeclampsia[J]. Clin Chem&Lab Med,2009,47(8):923-929.
[35] ZHU X M,HAN T,SARGENT I L,et al. Differential expression profile of microRNAs in human placentas from preeclamptic pregnancies vs normal pregnancies[J]. Am J Obstetrics&Gynecol,2009,200(6):1-7.
[36] BENTWICH I,AVNIEL A,KAROV Y,et al. Identification of hundreds of conserved and nonconserved human microRNAs[J]. Nat Genet,2005,37(7):766-770.
[37] DAI Y,QIU Z,DIAO Z,et al. MicroRNA-155 inhibits proliferation and migration of human extravillous trophoblast derived HTR-8/SVneo cells via down-regulating cyclin D1[J]. Placenta,2012,33(10):824-829.
[38] GAO W L,LIU M,YANG Y,et al. The imprinted H19 gene regulates human placental trophoblast cell proliferation via encoding miR-675 that targets Nodal Modulator 1(NOMO1)[J].RNA Biol,2012,9(7):1002-1010.
[39] LUO L,YE G,NADEEM L,et al. MicroRNA-378a-5p promotes trophoblast cell survival,migration and invasion by targeting Nodal[J]. J Cell Sci,2012,125(13):3124-3132.
[40] FU G,YE G,NADEEM L,et al. MicroRNA-376c impairs transforming growth factor-βand nodal signaling to promote trophoblast cell proliferation and invasion[J]. Hypertension,2013,61(4):864-872.
[41] CHIM S S,SHING T K,HUNG E C,et al. Detection and characterization of placental microRNAs in maternal plasma[J].Clin Chem,2008,54(3):482-490.
[42] LUO S S,ISHIBASHI O,ISHIKAWA G,et al. Human villous trophoblasts express and secrete placenta-specific microRNAs into maternal circulation via exosomes[J]. Biol Reprod,2009,81(4):717-729.
[43] ZHAO C,DONG J,JIANG T,et al. Early second-trimester serum MiRNA profiling predicts gestational diabetes mellitus[J].Plos One,2011,6(8):e23925.
[44] WONG H K,VEREMEYKO T,PATEL N,et al. De-repression of FOXO3a death axis by microRNA-132 and-212 causes neuronal apoptosis in Alzheimer's disease[J]. Hum Mol Genet,2013,22(15):3077-3092.
[45] LECCHI C,MARQUES A T,REDEGALLI M,et al. Circulating extracellular miR-22,miR-155,and miR-365 as candidate biomarkers to assess transport-related stress in turkeys[J]. Animal,2016,10(7):1213-1217.
[2] CAULFIELD M P,CAMBRIDGE H,FOSTER S F,et al. Heat stress:a major contributor to poor animal welfare associated with long-haul live export voyages[J]. Veter J,2014,199(2):223-228.
[3] WANG G G,WU X,MENG Q X,et al. Research progress on effect of transport stress on ruminants body function and meat quality[J]. Chin Animal Husbandry&Veter Med,2017,44(3):755-760.(in Chinese)王国艮,吴鑫,孟庆翔,等.运输应激对反刍动物机体功能及肉品质影响的研究进展[J].中国畜牧兽医,2017,44(3):755-760.
[4] ISLAM M T. Oxidative stress and mitochondrial dysfunctionlinked neurodegenerative disorders[J]. Neurol Res,2017,39(1):73-82.
[5] NYAYANIT D,GADGIL C J. Mathematical modeling of combinatorial regulation suggests that apparent positive regulation of targets by miRNA could be an artifact resulting from competition for m RNA[J]. RNA,2015,21(3):307-319.
[6] ZHANG N,WEI X,XU L. miR-150 promotes the proliferation of lung cancer cells by targeting P53[J]. Febs Lett,2013,587(15):2346-2351.
[7] SIENGDEE P,TRAKOOLJUL N,MURANI E,et al. MicroRNAs regulate cellular ATP levels by targeting mitochondrial energy metabolism genes during C2C12 myoblast differentiation[J]. Plos One,2015,10(5):e0127850.
[8] NEUTELINGS T,LAMBERT C A,NUSGENS B V,et al. Effects of mild cold shock(25℃)followed by warming up at 37℃on the cellular stress response[J]. Plos One,2013,8(7):e69687.
[9] LIAN S,GUO J,WANG L,et al. Impact of prenatal cold stress on placental physiology,inflammatory response,and apoptosis in rats[J]. Oncotarget,2017,8(70):115304-115314.
[10] ZHAO F Q,ZHANG Z W,YAO H D,et al. Effects of cold stress on m RNA expression of immunoglobulin and cytokine in the small intestine of broilers[J]. Res Veter Sci,2013,95(1):146-155.
[11] GUO W,LIAN S,ZHEN L,et al. The favored mechanism for coping with acute cold stress:upregulation of miR-210 in rats[J]. Cell Physiol Biochem,2018,46(5):2090-2102.
[12] LIAN S,WANG D,XU B,et al. Prenatal cold stress:effect on maternal hippocampus and offspring behavior in rats[J].Behav Brain Res,2018,346:1-10.
[13] PENG M L,YANG H M,LIU Y Z,et al. Progress in study on serum mi RNAs as biomarkers of diseases[J]. Chin J Biologicals,2015,28(9):985-988.(in Chinese)彭梦玲,杨焕民,刘艳芝,等.疾病相关生物标志物-血清miRNAs的研究进展[J].中国生物制品学杂志,2015,28(9):985-988.
[14] LI Z,GUO W,PENG M,et al. Identification of cold-responsive miRNAs in rats by deep sequencing[J]. J Thermal Biol,2017,66:114-124.
[15]臧树成,郭文晋,甄莉,等.急性冷应激对大鼠肝脏中novel miRNA的影响[C].中国生理学会内分泌代谢、比较生理与应激生理学术会议.辽宁沈阳,2017.
[16] YIN K,ZHAO L,FENG D,et al. Resveratrol attenuated low ambient temperature-induced myocardial hypertrophy via inhibiting cardiomyocyte apoptosis[J]. Cell Physiol&Biochem,2015,35(6):2451-2462.
[17] T AO C,HUAN G S,WANG Y,et al. Changes in white and brown adipose tissue microRNA expression in cold-induced mice[J]. Biochem&Biophys Res Commun,2015,463(3):193-199.
[18] PENG X K,HU J H,ZHANG E P. Effects of heat stress on physiological and biochemical indexes and expression levels of miRNA in peripheral blood of beef cattle,sheep and goats[J].J Domestic Animal Ecol,2018,39(3):1-7.彭孝坤,胡建宏,张恩平.热应激对肉牛和肉羊生理生化指标及外周血miRNA表达水平的影响[J].家畜生态学报,2018,39(3):1-7..
[19] ZHENG Y,CHEN K L,LI H X,et al. Profiling of differential expression of microRNAs in serum of heat-stresseded cows and bioinformatic analyses of miR-181a target genes[J]. J Nanjing Agr Univ,2014,37(6):130-136.郑月,陈坤琳,李惠侠,等.热应激奶牛血清miRNA表达谱及miR-181a靶基因分析[J].南京农业大学学报,2014,37(6):130-136.
[20] HU Y,CAI M C,WANG L,et al. The serum biochemical indexes and miRNA expression in cattle under heat stress and their correlation analysis[J]. Chin J Animal Veter Sci 2016,47(9):1840-1847.胡煜,蔡明成,王玲,等.热应激状态下牛血清生化指标、miRNA表达变化及其相关性分析[J].畜牧兽医学报,2016,47(9):1840-1847.
[21] GUO X,CHI S,XIA C,et al. Baicalin protects sertoli cells from heat stress-induced apoptosis via activation of the Fas/FasL pathway and Hsp72 expression[J]. Reprod Toxicol,2015,57(1):196-203.
[22] CHEN H,WANG J,HU B,et al. MiR-34a promotes Fas-mediated cartilage endplate chondrocyte apoptosis by targeting Bcl-2[J]. Mol&Cell Biochem,2015,406(1-2):21-30.
[23] ZHANG J F,SHI L L,ZHANG L,et al. MicroRNA-25 negatively regulates cerebral ischemia/reperfusion injury-induced cell apoptosis through Fas/FasL pathway[J]. J Mol Neurosci,2016,58(4):507-516.
[24] CAI M,HU Y,ZHENG T,et al. MicroRNA-216b inhibits heat stress-induced cell apoptosis by targeting Fas in bovine mammary epithelial cells[J]. Cell Stress&Chaperones,2018,5(23):921-931.
[25] SOHAL R S,ALLEN R G,FARMER K J,et al. Iron induces oxidative stress and may alter the rate of aging in the housefly,Musca domestica[J]. Mechanisms Ageing&Develop,1985,32(1):33-88.
[26] CUI. Y J. Effects of heat stress and oxidative stress on metabolism of skeletal muscle and protection of lipoic acid in finishing pigs[D]. Beijing:Chinese Academy of Agricultural Sciences,2016.崔艳军.热应激和氧化应激对肥育猪骨骼肌代谢的影响及硫辛酸的调控作用[D].北京:中国农业科学院,2016.
[27] MA Y F,SONG L W,GAO M,et al. Effect of oxidative stress on transition dairy cow mastitis and its regulation mechanisms[J]. Chin J Animal Nutrit,2015,27(3):671-676.马燕芬,宋利文,高民,等.氧化应激对围产期奶牛乳房炎的影响及其调控机制[J].动物营养学报,2015,27(3):671-676.
[28] SA R L,YANG B,AO C J. Research progress of natural plant extracts in animal oxidative stress[J]. Chin J Animal Nutrit,2018,30(6):2021-2026.萨茹丽,杨斌,敖长金.天然植物提取物在动物氧化应激中的研究概况[J].动物营养学报,2018,30(6):2021-2026.
[29] RUDOV A,BALDUINI W,CARLONI S,et al. Involvement of mi RNAs in placental alterations mediated by oxidative stress[J].Oxidative Med&Cell Longevity,2014,2014(1):103068.
[30] L C,V D S,E I,et al. Hypoxia-inducible factor 1-αinduces miR-210 in normoxic differentiating myoblasts[J]. J Biological Chem,2012,287(53):44761-44771.
[31] CHEN Z,WEN L,MARTIN M,et al. Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2(SREBP2)transactivation of MiRNA-92a[J].Circulation,2015,131(9):805-814.
[32] SANGOKOYA C,TELEN M J,CHI J T. microRNA miR-144modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease[J]. Blood,2010,116(20):4338-4348.
[33] YU D,DOS SANTOS C O,ZHAO G,et al. miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta[J].Genes&Develop,2010,24(15):1620-1633.
[34] HU Y,LI P,HAO S,et al. Differential expression of microRNAs in the placentae of Chinese patients with severe preeclampsia[J]. Clin Chem&Lab Med,2009,47(8):923-929.
[35] ZHU X M,HAN T,SARGENT I L,et al. Differential expression profile of microRNAs in human placentas from preeclamptic pregnancies vs normal pregnancies[J]. Am J Obstetrics&Gynecol,2009,200(6):1-7.
[36] BENTWICH I,AVNIEL A,KAROV Y,et al. Identification of hundreds of conserved and nonconserved human microRNAs[J]. Nat Genet,2005,37(7):766-770.
[37] DAI Y,QIU Z,DIAO Z,et al. MicroRNA-155 inhibits proliferation and migration of human extravillous trophoblast derived HTR-8/SVneo cells via down-regulating cyclin D1[J]. Placenta,2012,33(10):824-829.
[38] GAO W L,LIU M,YANG Y,et al. The imprinted H19 gene regulates human placental trophoblast cell proliferation via encoding miR-675 that targets Nodal Modulator 1(NOMO1)[J].RNA Biol,2012,9(7):1002-1010.
[39] LUO L,YE G,NADEEM L,et al. MicroRNA-378a-5p promotes trophoblast cell survival,migration and invasion by targeting Nodal[J]. J Cell Sci,2012,125(13):3124-3132.
[40] FU G,YE G,NADEEM L,et al. MicroRNA-376c impairs transforming growth factor-βand nodal signaling to promote trophoblast cell proliferation and invasion[J]. Hypertension,2013,61(4):864-872.
[41] CHIM S S,SHING T K,HUNG E C,et al. Detection and characterization of placental microRNAs in maternal plasma[J].Clin Chem,2008,54(3):482-490.
[42] LUO S S,ISHIBASHI O,ISHIKAWA G,et al. Human villous trophoblasts express and secrete placenta-specific microRNAs into maternal circulation via exosomes[J]. Biol Reprod,2009,81(4):717-729.
[43] ZHAO C,DONG J,JIANG T,et al. Early second-trimester serum MiRNA profiling predicts gestational diabetes mellitus[J].Plos One,2011,6(8):e23925.
[44] WONG H K,VEREMEYKO T,PATEL N,et al. De-repression of FOXO3a death axis by microRNA-132 and-212 causes neuronal apoptosis in Alzheimer's disease[J]. Hum Mol Genet,2013,22(15):3077-3092.
[45] LECCHI C,MARQUES A T,REDEGALLI M,et al. Circulating extracellular miR-22,miR-155,and miR-365 as candidate biomarkers to assess transport-related stress in turkeys[J]. Animal,2016,10(7):1213-1217.