不同剂量来曲唑用于多囊卵巢综合征患者促排卵的有效性及安全性研究
|
摘要
目的对多囊卵巢综合征患者采用不同剂量的来曲唑药物治疗措施,探讨其对患者促排卵的临床有效性及安全性。方法方便抽取该院2014年9月—2016年3月收治的120例多囊卵巢综合征患者作为研究对象,依据数字表法将其随机分为3组,每组40例。其中一组采用2.5 m L的来曲唑,设为A组;一组采用5.0 m L的来曲唑,设为B组;一组采用7.5 m L的来曲唑,设为C组。分别对3组患者进行不同剂量的药物治疗措施,并观察治疗后患者的促排卵改善情况。结果 A组患者的总有效率为82.5%,B组为92.5%,C组为97.5%,A组与C组相比差异具有统计学意义(P<0.05);A组的妊娠率以及排卵率均明显低于C组,组间比较差异具有统计学意义(P<0.05)。结论对多囊卵巢综合症患者应用较高剂量的来曲唑可有效促进排卵,提高了妊娠率,且安全可靠,值得推广。
Objective Polycystic ovary syndrome were treated with different doses of letrozole azole drug treatment measures, wrought iron investigate the clinical efficacy and safety of the patient ovulation. Methods Convenient selection extraction September 2014 to March 2016 our hospital 120 cases of polycystic ovary syndrome patients as research subjects,according to the digital table were randomly divided into three groups of 40 cases. One group received 2.5 m L of letrozole,set A group; a group with 5.0 m L of letrozole to group B; a group with 7.5 m L of letrozole to group C. Respectively, three groups of patients with different doses of the drug treatment and observe the patient's ovulation improvement after treatment.Results A group of patients with a total effective rate of 82.5%, 92.5% in group B, group C was 97.5%, A group and C group difference was statistically significant(P<0.05); A group of pregnancy and ovulation rate significantly lower than group C, the difference between groups was statistically significant(P<0.05). Conclusion Polycystic ovary syndrome patients higher doses of letrozole can effectively promote ovulation, increase the pregnancy rate, and secure, worthy of promotion.
Objective Polycystic ovary syndrome were treated with different doses of letrozole azole drug treatment measures, wrought iron investigate the clinical efficacy and safety of the patient ovulation. Methods Convenient selection extraction September 2014 to March 2016 our hospital 120 cases of polycystic ovary syndrome patients as research subjects,according to the digital table were randomly divided into three groups of 40 cases. One group received 2.5 m L of letrozole,set A group; a group with 5.0 m L of letrozole to group B; a group with 7.5 m L of letrozole to group C. Respectively, three groups of patients with different doses of the drug treatment and observe the patient's ovulation improvement after treatment.Results A group of patients with a total effective rate of 82.5%, 92.5% in group B, group C was 97.5%, A group and C group difference was statistically significant(P<0.05); A group of pregnancy and ovulation rate significantly lower than group C, the difference between groups was statistically significant(P<0.05). Conclusion Polycystic ovary syndrome patients higher doses of letrozole can effectively promote ovulation, increase the pregnancy rate, and secure, worthy of promotion.
引文
[1]刘琼.克罗氯米芬与来曲唑治疗多囊卵巢不孕症患者的对比研究[J].上海医药,2015,23(5):24-25,36.
[2]吕艳蕊.来曲唑联合人绝经期促性腺激素治疗克罗米酚抵抗的多囊卵巢综合症研究[J].实用妇科内分泌电子杂志,2015,2(11):100-101.
[3]马嘉嘉.来曲唑与克罗米芬在多囊卵巢综合症患者中的疗程观察[J].医药前沿,2015,5(32):164-165.
[4]马莉.来曲唑治疗多囊卵巢综合症临床研究[J].中外医疗,2015,34(11):74-75.
[5]林美丽.来曲唑、他莫昔芬和氯米芬治疗多囊卵巢综合征不孕疗效比较[J].中外女性健康研究,2015,14(17):206-206,211.
[6]金红菊.克罗氯米芬与来曲唑治疗多囊卵巢不孕症患者的对比分析[J].临床研究,2016,7(1):83-84.
[7]石萍,郭建芳.中药配合来曲唑对多囊卵巢综合症促排卵临床疗效的观察[J].光明中医,2014,8(5):1038-1039.
[8]张小芳,黄建平,傅岚,等.多囊卵巢综合征用来曲唑及人绝经期促性腺激素促排卵疗效观察[J].临床医药实践,2015,22(11):827-828.
[9]郭兰萍.来曲唑治疗多囊卵巢综合症的临床疗效评估[J].医药前沿,2015,5(32):121-122.
[10]韦娟冰.来曲唑用于多囊卵巢综合征患者促排卵的临床疗效及安全性评价[J].中国临床药理学杂志,2015,31(19):1928-1930.
[2]吕艳蕊.来曲唑联合人绝经期促性腺激素治疗克罗米酚抵抗的多囊卵巢综合症研究[J].实用妇科内分泌电子杂志,2015,2(11):100-101.
[3]马嘉嘉.来曲唑与克罗米芬在多囊卵巢综合症患者中的疗程观察[J].医药前沿,2015,5(32):164-165.
[4]马莉.来曲唑治疗多囊卵巢综合症临床研究[J].中外医疗,2015,34(11):74-75.
[5]林美丽.来曲唑、他莫昔芬和氯米芬治疗多囊卵巢综合征不孕疗效比较[J].中外女性健康研究,2015,14(17):206-206,211.
[6]金红菊.克罗氯米芬与来曲唑治疗多囊卵巢不孕症患者的对比分析[J].临床研究,2016,7(1):83-84.
[7]石萍,郭建芳.中药配合来曲唑对多囊卵巢综合症促排卵临床疗效的观察[J].光明中医,2014,8(5):1038-1039.
[8]张小芳,黄建平,傅岚,等.多囊卵巢综合征用来曲唑及人绝经期促性腺激素促排卵疗效观察[J].临床医药实践,2015,22(11):827-828.
[9]郭兰萍.来曲唑治疗多囊卵巢综合症的临床疗效评估[J].医药前沿,2015,5(32):121-122.
[10]韦娟冰.来曲唑用于多囊卵巢综合征患者促排卵的临床疗效及安全性评价[J].中国临床药理学杂志,2015,31(19):1928-1930.