摘要
目的:研究三维腔内后装与常规腔内后装放疗治疗Ⅱ_b-Ⅲ_b期宫颈癌近期疗效的比较。方法:本研究观察对象为2014年1月至2015年1月于我院治疗的82例Ⅱ_b-Ⅲ_b期宫颈癌患者,现进行病历资料回顾性分析,根据不同腔内后装放疗治疗进行分组。将采用常规腔内后装放疗治疗的40例患者设为对照组,采用三维腔内后装放疗治疗的42例患者设为观察组。放疗治疗6~8次后进行客观疗效评价,并比较两组患者骨髓抑制、放射性膀胱炎以及急性放射性肠炎发生情况,随访2年,记录2年生存率、无瘤生存率、局部复发率以及远处转移率。结果:观察组客观疗效总缓解率为95. 24%,显著高于对照组(85. 00%),差异具有统计学意义(P <0. 05);两组骨髓抑制以及急性放射性肠炎不良反应分级差异无统计学意义(P> 0. 05);观察组2年总生存率为85. 71%,与对照组(72. 50%)差异具有统计学意义(P <0. 05);观察组无瘤生存率显著高于对照组,局部复发率以及远处转移率显著低于对照组,差异具有统计学意义(P <0. 05)。结论:三维腔内后装较常规腔内后装放疗治疗Ⅱ_b-Ⅲ_b期宫颈癌能取得更好的客观疗效,降低肿瘤复发及转移,同时不增加患者不良反应,治疗中晚期宫颈癌安全有效。
Objective: To study the short-term efficacy comparison of three-dimensional intracavity posterior mounting and conventional intracavity posterior mounting in the radiotherapy of cervical cancer Ⅱ_b-Ⅲ_b. Methods:Eighty-two patients with stage Ⅱ_b-Ⅲ_bcervical cancer treated in our hospital from January 2014 to January 2015 were selected as our objects in this study. A retrospective analysis was performed on the medical records and patients were grouped according to different intracavity posterior mounting. 40 patients treated with conventional intracavity posterior mounting were set as a control group,and 42 patients treated with three-dimensional intracavity posterior mounting were set as an observation group. 6 ~ 8 times radiotherapy were performed to evaluate the objective effect,and the incidence of myelosuppression,radiation cystitis and acute radiation enteritis were compared between the two groups. Follow-up was performed for two years. The survival rate,disease-free survival rate,local recurrence rate and distant metastasis rate were recorded. Results: The total remission rate of objective group in the observation group was 95. 24%,which was significantly higher than that in the control group( 85. 00%). The difference was statistically significant( P < 0. 05). There were no significant differences in the grades of bone marrow suppression,radiation cystitis and acute radiation enteritis between the two groups( P > 0. 05). The two-year overall survival rate in the observation group was 85. 71%,which was significantly higher than that in the control group( 72. 50%),and the difference was statistically significant( P < 0. 05). The disease-free survival rate in the observation group was significantly higher than that in the control group,and the local recurrence rate and the distant metastasis rate in the observation group were significantly lower than those in the control group,and the difference was statistically significant( P < 0. 05).Conclusion: Compared to conventional intracavity posterior mounting,three-dimensional intracavity posterior mounting can achieve a better objective efficacy in the radiotherapy of Ⅱ_b-Ⅲ_bcervical cancer,reduce tumor recurrence and metastasis and cannot increase the toxicity of patients at the same time. This treatment is safe and effective in the treatment of advanced cervical cancer.
引文
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