摘要
酰腙及其金属配合物因独特的结构,具有抗肿瘤、抗菌、抗结核、消炎镇痛、抗氧化、杀虫等多样的生物活性,在医药、农业等多个领域具有重要的作用。本文对该类化合物在生物活性方面的研究近况进行综述。
Due to the unique structure,acylhydrazone and its metal complexes have various biological activities,such as anti-tumor,antibacterial,anti-tuberculosis,anti-inflammatory and analgesic,anti-oxidation and insecticidal. They played important roles in the field of pesticides and medicinal,etc. The recent progress in biological activity of these compounds is reviewed in this paper.
引文
[1]肖文,张华新,卢忠林,等.酰腙化合物的分类、配位和性质[J].中山大学学报(自然科学版),2001,40(1):39-43.
[2]邓记华.酰腙类Schiff碱及其金属配合物的研究进展[J].宜春学院学报,2008,30(2):80-82.
[3]李志有.酰腙希夫碱及其金属配合物的合成和生物活性的研究[D].中南民族大学,2013.
[4]韩学锋,蔡红新,贾磊,等.两个吡咯酰腙铜配合物的制备、结构及抗肿瘤活性[J].无机化学学报,2015,31(7):1453-1459.
[5]Feng,Xiao Xia,et al. Detailed profiling on DNA binding affinity,cytotoxicity and pathway of induced cell death of novel watersoluble Cu(Ⅱ)-based acylhydrazone porphyrin derivatives. Dyes&Pigments,2016,136:773-781.
[6]杨莹丽.苯甲醛氮芥吡啶酰腙及其铜配合物抗肿瘤机制研究[D].新乡医学院,2016.
[7]蒋伍玖,谭宇星,庾江喜,等.2-羰基-3-苯基丙酸芳甲酰腙二(2,4-二氯苄基)锡配合物的合成、晶体结构及生物活性[J].无机化学学报,2016,32(8):1383-1390.
[8]李书平,姜亚玲,王蕊,等.恩诺沙星噁二唑硫乙酰腙类化合物的合成及抗肿瘤活性[J].沈阳药科大学学报,2017,34(9):763-767.
[9]叶英,索有瑞,杨芳,等.新型双吲哚酰腙类化合物的微波合成及抗菌活性研究[J].化学试剂,2015,37(7):585-589.
[10]海士坤,娄淑芳,仇晓阳.芳酰腙铜(Ⅱ)和锌(Ⅱ)配合物的合成、晶体结构及抗菌活性[J].无机化学学报,2016,32(5):906-912.
[11]王海潮,李红侠.含2H吡唑结构的甲酰腙衍生物的合成与抗菌活性研究[J].宿州学院学报,2017,32(3):100-105.
[12]Joshi S D,Kumar D,Dixit S R,et al. Synthesis,characterization and antitubercular activities of novel pyrrolyl hydrazones and their Cu-complexes[J]. European Journal of Medicinal Chemistry,2016,121:21-39.
[13]任金凤,蒙建州,赵跃,等.新型酰腙席夫碱类化合物的设计、合成及抗结核活性研究[J].中国医药生物技术,2017,12(3):201-206.
[14]Meng J,Yang Y,Xiao C,et al. Identification and Validation of Aspartic Acid Semialdehyde Dehydrogenase as a New Anti-Mycobacterium Tuberculosis Target[J]. International Journal of Molecular Sciences,2015,16(10):23572-23586.
[15]Moradi A,Navidpour L,Amini M,et al. Design and synthesis of 2-phenoxynicotinic acid hydrazides as anti-inflammatory and analgesic agents[J]. Archiv Der Pharmazie,2010,343(9):509-518.
[16]段志芳,邵玲.含水杨醛席夫碱结构的黄酮衍生物的固相合成与抗氧化及抗菌活性[J].应用化学,2015,32(9):1005-1013.
[17]曾凡付,王荣,李水清.酰腙席夫碱化合物的合成及其杀虫活性研究[J].湖北农业科学,2015(17):4192-4194.
[18]李浩杰,林灿,俞雪萍,等.取代酰腙类化合物的合成及其杀虫活性研究[J].云南农业大学学报,2016,V31(4):761-766.
[19]李水清,易雄健,任俊峰,等.芳香醛缩对甲基苯甲酰腙的合成及其杀虫活性[J].湖北农业科学,2016,55(21):5545-5547.
[20]杜欢,范治江,杨岚,等.含喹唑啉-4-酮片段的新型1,2,4-三唑酰腙类衍生物的合成及抗菌活性[J].有机化学,2018,38(2):531-538.
[21]田月娥,车志平,刘圣明,等.N-苯磺酰基-3-酰基吲哚苯甲酰腙类化合物的抑菌活性[J].农药,2018,57(4):263-265.
[22]谢嘉霖,彭化南,陈鹏,等.水杨醛异烟酰腙Cu~(2+)荧光探针的研究[J].分析试验室,2017(12):1456-1460.
[23]Yu X,Shi L,Ke S. Acylhydrazone derivatives as potential anticancer agents:synthesis,bio-evaluation and mechanism of action[J].Bioorganic&Medicinal Chemistry Letters,2015,25(24):5772-5776.