妊娠期妇女甲状腺功能减退对妊娠结局和胎儿不良结局的影响
摘要
目的探讨妊娠期妇女甲状腺功能减退对妊娠结局和胎儿的影响。方法选取我院住院分娩的临床甲状腺功能减退孕妇126例为甲减组,亚临床甲状腺功能减退孕妇120例为亚甲减组,另选取同期在本院住院分娩的健康孕妇134例为对照组,观察三组妊娠结局和胎儿不良结局。结果三组产后出血、胎盘早剥和前置胎盘发生率,差异无统计学意义(P>0.05);甲减组和亚甲减组早产发生率和贫血发生率均明显高于对照组,差异有统计学意义(P<0.05)。三组胎儿畸形发生率,差异无统计学意义(P>0.05);甲减组和亚甲减组低体质量发生率和胎儿窘迫发生率明显高于对照组(P<0.05),胎儿Apgar评分分明显低于对照组,差异有统计学意义(P<0.05)。结论妊娠期妇女甲状腺功能减退可明显导致不良妊娠结局发生率增加,应及早发现,及早治疗,避免对胎儿造成不利影响。
引文
[1]李晶,李珊.妊娠期糖尿病合并亚临床甲状腺功能减退症临床状况及其对妊娠结局的影响研究[J].中国妇幼保健,2015,30(31):5327-5328.
[2]牛桂珍,金京,赵瑛.妊娠期甲状腺功能减退对孕妇和子代的影响及干预治疗[J].中国地方病防治杂志,2016,31(1):37-38.
[3]侯美芹,王治洁,侯克柱.妊娠期妇女甲状腺功能减退对妊娠结局和胎儿影响的分析[J].中华流行病学杂志,2016,37(5):722-724.
[4]陈刚,高燕云.妊娠亚临床甲减对胎儿发育及妊娠结局的影响[J].中国妇幼健康研究杂志,2013,24(5):698-700.
[5]Benhadi N,Wiersinga WM,Reitsma JB,et al.Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage,fetal or neonatal death[J].Eur Endocrinol,2009,31:523-535.
[6]Cas ey BM,Dashe JS,Wells CE,et al.Subclinical hypothyroidism and pregnancy outcomes.[J].Obstet Gynecol,2005,105:239-245.
[7]Mannisto T,Mendola P,Grewal J.Thyroid diseases and adverse preg-nancy outcomes in a contemporary us cohort.[J].J Clin Endocrinol Metab,2013,98(7):2725-2733.
[8]余帆,冯玲.妊娠期甲状腺功能减退对妊娠结局和胎儿的影响[J].中国妇幼保健,2014,29(33):5412-5413.
[9]兰玉,赵翠柳,任旭.合并亚临床甲状腺功能减退的妊娠结局[J].广东医学,2012,33(15):2321-2322.
[10]Norris SA,Osmond C,Gigante D,et al.Size at birth,weight gain in infancy and childhood,and adult diabetes risk in five low-or middle-income country birth cohorts[J].Diabetes Care,2012,35:72-79.
[2]牛桂珍,金京,赵瑛.妊娠期甲状腺功能减退对孕妇和子代的影响及干预治疗[J].中国地方病防治杂志,2016,31(1):37-38.
[3]侯美芹,王治洁,侯克柱.妊娠期妇女甲状腺功能减退对妊娠结局和胎儿影响的分析[J].中华流行病学杂志,2016,37(5):722-724.
[4]陈刚,高燕云.妊娠亚临床甲减对胎儿发育及妊娠结局的影响[J].中国妇幼健康研究杂志,2013,24(5):698-700.
[5]Benhadi N,Wiersinga WM,Reitsma JB,et al.Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage,fetal or neonatal death[J].Eur Endocrinol,2009,31:523-535.
[6]Cas ey BM,Dashe JS,Wells CE,et al.Subclinical hypothyroidism and pregnancy outcomes.[J].Obstet Gynecol,2005,105:239-245.
[7]Mannisto T,Mendola P,Grewal J.Thyroid diseases and adverse preg-nancy outcomes in a contemporary us cohort.[J].J Clin Endocrinol Metab,2013,98(7):2725-2733.
[8]余帆,冯玲.妊娠期甲状腺功能减退对妊娠结局和胎儿的影响[J].中国妇幼保健,2014,29(33):5412-5413.
[9]兰玉,赵翠柳,任旭.合并亚临床甲状腺功能减退的妊娠结局[J].广东医学,2012,33(15):2321-2322.
[10]Norris SA,Osmond C,Gigante D,et al.Size at birth,weight gain in infancy and childhood,and adult diabetes risk in five low-or middle-income country birth cohorts[J].Diabetes Care,2012,35:72-79.