吉林省出血热发病影响因素病例对照研究
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摘要
目的探讨出血热发病影响因素、评价出血热疫苗免疫效力。方法采用1∶2配比病例对照研究,对2013年第3季度吉林省疫情网络报告的实验室确诊病例154例及308例对照的相关资料进行条件Logistic回归分析。结果经多因素Logistic回归分析,发病前2个月接触鼠类、野外住宿史、鼠洞附近坐卧、外伤史、外出史为出血热危险因素,其OR值依次为9.08、7.18、3.83、3.17、3.13;接种疫苗及饮食前后洗手是保护因素,其OR值分别为0.06、0.14;疫苗保护效力为接种2针疫苗83.48%、3针疫苗94.94%。结论应加大宣传力度,全面提高人群疾病知晓率、疫苗接种率,逐步改变人群行为习惯,降低发病风险。
Objective To explore the onset influential factors of hemorrhagic fevers,and to evaluate the immunocompetence of hemorrhagic fever vaccine. Methods To adopt the method of a case- control study in 1: 2 proportion,then analyzed all of the 154 laboratory confirmed cases of epidemic network report( there was no self- paying injections of hemorrhagic fever vaccine before 2009) in Jilin province for the third quarter in 2003 and tried to make a conditional Logistic regression analysis of the related data of 308 contrasted relative information. Results According to multiple Logistic factor regression analysis,the influential factors of the hemorrhagic fever should include: people who had a mice- contact history,a staying- in- the- wild history for premorbid 2 months,and those people who had a history of sitting beside the rats' holes,a traumatic or a going- out history. The OR numbers were 9. 08,7. 18,3. 83,3. 17,and 3. 13; vaccination and washing hands before and after eating were the protective factors,the OR numbers relatively are 0. 06,0. 14. Vaccine protective efficiency is 83. 48% for 2 injections and 94. 94% for 3 injections. Conclusion It should be further strengthened the publicity and make all- round improvement of people's disease awareness and vaccination coverage,so as to gradually change people's behavioral habits and reduce the risk of diseases.
Objective To explore the onset influential factors of hemorrhagic fevers,and to evaluate the immunocompetence of hemorrhagic fever vaccine. Methods To adopt the method of a case- control study in 1: 2 proportion,then analyzed all of the 154 laboratory confirmed cases of epidemic network report( there was no self- paying injections of hemorrhagic fever vaccine before 2009) in Jilin province for the third quarter in 2003 and tried to make a conditional Logistic regression analysis of the related data of 308 contrasted relative information. Results According to multiple Logistic factor regression analysis,the influential factors of the hemorrhagic fever should include: people who had a mice- contact history,a staying- in- the- wild history for premorbid 2 months,and those people who had a history of sitting beside the rats' holes,a traumatic or a going- out history. The OR numbers were 9. 08,7. 18,3. 83,3. 17,and 3. 13; vaccination and washing hands before and after eating were the protective factors,the OR numbers relatively are 0. 06,0. 14. Vaccine protective efficiency is 83. 48% for 2 injections and 94. 94% for 3 injections. Conclusion It should be further strengthened the publicity and make all- round improvement of people's disease awareness and vaccination coverage,so as to gradually change people's behavioral habits and reduce the risk of diseases.
引文
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〔3〕姚来顺,马洪然,卢欣荣,等.吉林省流行性出血热疫情分析〔J〕.中国卫生工程学,2011,10(6):504-506
〔4〕吴光华,王忠灿,姜志宽,等.肾综合征出血热与鼠的监测和防控〔J〕.中华卫生杀虫药械,2012,18(5):370-374.
〔5〕王芹,周航,李德新,等.2009年中国肾综合征出血热监测分析〔J〕.疾病监测,2010,25(12):938-943.
〔6〕陈志军,龚建人,蔡正华.西安市出血热疫苗接种控制出血热疫情效果分析〔J〕.职业与健康,2008,24(13):1281-1283.
〔7〕蔡正华,于立芬,李倩,等。某市肾综合征出血热疫苗免疫效果评价〔J〕.中国卫生质量管理,2011,18(6):85-87.
〔8〕张桂琴,薛付忠,王洁贞,等.大规模人群接种II型肾综合征出血热疫苗的流行病学效果研究〔J〕.山东大学学报(医学版),2007,45(10):981-984.
〔9〕李劲松,陈志军,候铁军,等.西安市肾综合征出血热的危险因素研究〔J〕.中华疾病控制杂志,2013,17(7):564-566.
〔2〕黄飚,宋绪华,张未寒.吉林省肾综合征出血热流行病学调查〔J〕.中国热带医学,2005,5(8):1640-1641.
〔3〕姚来顺,马洪然,卢欣荣,等.吉林省流行性出血热疫情分析〔J〕.中国卫生工程学,2011,10(6):504-506
〔4〕吴光华,王忠灿,姜志宽,等.肾综合征出血热与鼠的监测和防控〔J〕.中华卫生杀虫药械,2012,18(5):370-374.
〔5〕王芹,周航,李德新,等.2009年中国肾综合征出血热监测分析〔J〕.疾病监测,2010,25(12):938-943.
〔6〕陈志军,龚建人,蔡正华.西安市出血热疫苗接种控制出血热疫情效果分析〔J〕.职业与健康,2008,24(13):1281-1283.
〔7〕蔡正华,于立芬,李倩,等。某市肾综合征出血热疫苗免疫效果评价〔J〕.中国卫生质量管理,2011,18(6):85-87.
〔8〕张桂琴,薛付忠,王洁贞,等.大规模人群接种II型肾综合征出血热疫苗的流行病学效果研究〔J〕.山东大学学报(医学版),2007,45(10):981-984.
〔9〕李劲松,陈志军,候铁军,等.西安市肾综合征出血热的危险因素研究〔J〕.中华疾病控制杂志,2013,17(7):564-566.