HSP27在肿瘤中的研究进展
摘要
<正>热休克蛋白(heat shock proteins,HSPs)是在从细菌到哺乳动物中广泛存在的一类热应激蛋白质[1]。当有机体暴露于高温的时候,就会由热激发合成热休克蛋白质,作为分子伴侣以防止蛋白质聚集,对抗正常的细胞死亡,从而调节细胞的生存和死亡的平衡[2]。热休克蛋白质按照蛋白质分子量的大小共分为5类,分别为HSP110、HSP90、HSP70、HSP60 以及小分子热休克蛋白质。小分子热休克蛋白质分子量为12～34 KD,热休克蛋
引文
[1] NAHLEH Z, TFAYLI A, NAJM A, et al. Heat shock proteins in cancer:targeting the ‘chaperones’[J].Future Med Chem,2012,4(7):927-935.
[2] ZININGA T, RAMATSUI L, SHONHAI A. Heat shock proteins as immunomodulants[J]. Molecules,2018,23(11): 2846.
[3] HAN L, JIANG Y, HAN D, et al. Hsp27 regulates epithelial mesenchymal transition, metastasis and proliferation in colorectal carcinoma[J].Oncol Lett,2018,16(4):5309-5316.
[4] 张宝宏,谢飞,任海军,刘波.HSP27对细胞迁移的调控[J].生物化学与生物物理进展,2017,44(2):110-116.
[5] FREILICH R, BETEGON M, TSE E, et al. Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau[J].Nat Commun, 2018,9(1):4563.
[6] MISHRA S, CHANDLER S A, WILLIAMS D, et al. Engineering of a polydisperse small heat-shock protein reveals conserved motifs of oligomer plasticity[J].Structure,2018,26(8):1116-1126.
[7] LAGANOWSKY A, BENESCH J L, LANDAU M, et al. Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function[J].Protein Sci,2010,19(5):1031-1043.
[8] 李红波,苏磊,林新峰,等.HSP27在热打击致F98细胞氧化应激损伤及细胞凋亡中的作用[J].解放军医学杂志,2018,43(10):854-859.
[9] DOKLADNY K, MYERS O B, MOSELEY P L. Heat shock response and autophagy[J]. Autophagy,2015,11(2):200-213.
[10] ZHOU F, HUANG X, PAN Y, et al. Resveratrol protects HaCaT cells from ultraviolet B-induced photoaging via upregulation of HSP27 and modulation of mitochondrial caspase-dependent apoptotic pathway[J].Biochem Biophys Res Commun,2018,499(3):662-668.
[11] ZHANG Y, FENG Z, WANG W, et al. Expression of heat shock protein-27 (HSP27) and P38MAPK in esophageal squamous cell carcinoma[J].Med Sci Monit,2017,23:5246-5253.
[12] LUZ C C, NOGUTI J, GIANNI M S, et al. HSP27 and HSP70 expression in esophageal squamous[J].Asian Pac J Cancer Prev,2017,18(3):789-794.
[13] STOPE M B, KLINKMANN G, DIESING K, et al. Heat shock protein HSP27 secretion by ovarian cancer cells is linked to intracellular expression levels,occurs independently of the endoplasmic reticulum pathway and HSP27's phosphorylation status,and is mediated by exosome liberation[J].Dis Markers,2017,2017:1575374.
[14] YE H, HUANG H, CAO F, et al. HSPB1 enhances SIRT2-Mediated G6PD activation and promotes glioma cell proliferation[J].PLoS One,2016,11(10):e0164285.
[15] HOMAEI S F, MEHRAD M H, TASBANDI M, et al. Anti-heat shock protein-27 antibody levels in women with breast cancer:association with disease complications and two-year disease-free survival[J].Asian Pac J Cancer Prev,2016,17(10):4655-4659.
[16] LI S, ZHANG W, FAN J, et al. Clinicopathological and prognostic significance of heat shock protein 27 (HSP27) expression in non-small cell lung cancer: a systematic review and meta-analysis[J].Springerplus,2016,5(1):1165.
[17] ETO D, HISAKA T, HORIOCHI H, et al. Expression of HSP27 in hepatocellular carcinoma[J]. Anticancer Res,2016,36(7):3775-3779.
[18] KAIGORODOVA E V, ZAVYALOVA M V, BYCHKOV V A, et al. Functional state of the HSP27 chaperone as a molecular marker of an unfavorable course of larynx cancer[J].Cancer Biomark,2016,17(2):145-153.
[19] 文静,方念,邓欢,等.热休克蛋白27在胃癌中的表达及意义[J].江西医药,2017,52(3):198-199,203.
[20] HUANG C S, HUANG C Y, LEE C H, et al. IGFBP2 plays an important role in heat shock protein 27-mediated cancer progression and metastasis[J].Oncotarget,2017,8(33):54978-54992.
[21] GE H, DU J, XU J, et al. SUMOylation of HSP27 by small ubiquitin-like modifier 2/3 promotes proliferation and invasion of hepatocellular carcinoma cells[J].Cancer Biol Ther,2017,18(8):552-559.
[22] YASUDA K, HIROHASHI Y, MARIYA T, et al. Phosphorylation of HSF1 at serine 326 residue is related to the maintenance of gynecologic cancer stem cells through expression of HSP27[J].Oncotarget,2017,8(19):31540-31553.
[23] CHEN W, REN X, WU J, et al. HSP27 associates with epithelial-mesenchymal transition, stemness and radioresistance of salivary adenoid cystic carcinoma[J].Cell Mol Med, 2018,22(4):2283-2298.
[24] MO X M, LI L, ZHU P, et al. Up-regulation of HSP27 by ERα/Sp1 facilitates proliferation and confers resistance to apoptosis in human papillary thyroid cancer cells[J].Mol Cell Endocrinol,2016,431:71-87.
[25] CHOI S H, NAM J K, KIM B Y, et al. HSPB1 inhibits the Endothelial-to-Mesenchymal transition to suppress pulmonary fibrosis and lung tumorigenesis[J].Cancer Res,2016,76(5):1019-1030.
[26] ZHANG Y, TAO X, JIN G, et al. A targetable molecular chaperone HSP27 confers aggressiveness in hepatocellular carcinoma[J].Theranostics,2016,6(4):558-570.
[27] DENG W, ZHANG Y, GU L, et al. Heat shock protein 27 downstream of P38-PI3K/Akt signaling antagonizes melatonin-induced apoptosis of SGC-7901 gastric cancer cells[J].Cancer Cell Int,2016,16:5.
[28] ZHANG S, HU Y, HUANG Y, et al. Heat shock protein 27 promotes cell proliferation through activator protein-1 in lung cancer[J].Oncol Lett,2015,9(6):2572-2576.
[29] ZHANG Y, FENG Z, WANG W, et al. Expression of heat shock protein-27(HSP27) and P38MAPK in esophageal squamous cell carcinoma[J].Med Sci Monit,2017,23:5246-5253.
[30] LEE M S, LEE J, LEE S, et al. Clinical, prognostic, and therapeutic significance of heat shock protein 27 in bladder cancer[J].Oncotarget,2018,9(8):7961-7974.
[31] KAIGORODOVA E V, ZAVYALOVA M V, BYCHKOV V A, et al. Functional state of the HSP27 chaperone as a molecular marker of an unfavorable course of larynx cancer[J].Cancer Biomark,2016,17(2):145-153.
[32] OKUNO M, YASUDA I, ADACHI S, et al. The significance of phosphorylated heat shock protein 27 on the prognosis of pancreatic cancer[J].Oncotarget,2016,7(12):14291-14299.
[33] ISHIDA T, ISHII Y, TSURUTA M, et al. Cetuximab promotes SN38 sensitivity via suppression of heat shock protein 27 in colorectal cancer cells with wild-type RAS[J].Oncol Rep,2017,38(2):926-932.
[34] KONDA J D, OLIVERO M, MUSIANI D, et al. Heat-shock protein 27 (HSP27, HSPB1) is synthetic lethal to cells with oncogenic activation of MET, EGFR and BRAF[J].Mol Oncol,2017,11(6):599-611.
[35] LIU C L, CHEN S F, WU M Z, et al. The molecular and clinical verification of therapeutic resistance via the p38 MAPK-HSP27 axis in lung cancer[J].Oncotarget,2016,7(12):14279-14290.
[36] LU H, SUN C, ZHOU T, et al. HSP27 knockdown increases cytoplasmic p21 and cisplatin sensitivity in ovarian carcinoma cells[J].Oncol Res,2016,23(3):119-128.
[2] ZININGA T, RAMATSUI L, SHONHAI A. Heat shock proteins as immunomodulants[J]. Molecules,2018,23(11): 2846.
[3] HAN L, JIANG Y, HAN D, et al. Hsp27 regulates epithelial mesenchymal transition, metastasis and proliferation in colorectal carcinoma[J].Oncol Lett,2018,16(4):5309-5316.
[4] 张宝宏,谢飞,任海军,刘波.HSP27对细胞迁移的调控[J].生物化学与生物物理进展,2017,44(2):110-116.
[5] FREILICH R, BETEGON M, TSE E, et al. Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau[J].Nat Commun, 2018,9(1):4563.
[6] MISHRA S, CHANDLER S A, WILLIAMS D, et al. Engineering of a polydisperse small heat-shock protein reveals conserved motifs of oligomer plasticity[J].Structure,2018,26(8):1116-1126.
[7] LAGANOWSKY A, BENESCH J L, LANDAU M, et al. Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function[J].Protein Sci,2010,19(5):1031-1043.
[8] 李红波,苏磊,林新峰,等.HSP27在热打击致F98细胞氧化应激损伤及细胞凋亡中的作用[J].解放军医学杂志,2018,43(10):854-859.
[9] DOKLADNY K, MYERS O B, MOSELEY P L. Heat shock response and autophagy[J]. Autophagy,2015,11(2):200-213.
[10] ZHOU F, HUANG X, PAN Y, et al. Resveratrol protects HaCaT cells from ultraviolet B-induced photoaging via upregulation of HSP27 and modulation of mitochondrial caspase-dependent apoptotic pathway[J].Biochem Biophys Res Commun,2018,499(3):662-668.
[11] ZHANG Y, FENG Z, WANG W, et al. Expression of heat shock protein-27 (HSP27) and P38MAPK in esophageal squamous cell carcinoma[J].Med Sci Monit,2017,23:5246-5253.
[12] LUZ C C, NOGUTI J, GIANNI M S, et al. HSP27 and HSP70 expression in esophageal squamous[J].Asian Pac J Cancer Prev,2017,18(3):789-794.
[13] STOPE M B, KLINKMANN G, DIESING K, et al. Heat shock protein HSP27 secretion by ovarian cancer cells is linked to intracellular expression levels,occurs independently of the endoplasmic reticulum pathway and HSP27's phosphorylation status,and is mediated by exosome liberation[J].Dis Markers,2017,2017:1575374.
[14] YE H, HUANG H, CAO F, et al. HSPB1 enhances SIRT2-Mediated G6PD activation and promotes glioma cell proliferation[J].PLoS One,2016,11(10):e0164285.
[15] HOMAEI S F, MEHRAD M H, TASBANDI M, et al. Anti-heat shock protein-27 antibody levels in women with breast cancer:association with disease complications and two-year disease-free survival[J].Asian Pac J Cancer Prev,2016,17(10):4655-4659.
[16] LI S, ZHANG W, FAN J, et al. Clinicopathological and prognostic significance of heat shock protein 27 (HSP27) expression in non-small cell lung cancer: a systematic review and meta-analysis[J].Springerplus,2016,5(1):1165.
[17] ETO D, HISAKA T, HORIOCHI H, et al. Expression of HSP27 in hepatocellular carcinoma[J]. Anticancer Res,2016,36(7):3775-3779.
[18] KAIGORODOVA E V, ZAVYALOVA M V, BYCHKOV V A, et al. Functional state of the HSP27 chaperone as a molecular marker of an unfavorable course of larynx cancer[J].Cancer Biomark,2016,17(2):145-153.
[19] 文静,方念,邓欢,等.热休克蛋白27在胃癌中的表达及意义[J].江西医药,2017,52(3):198-199,203.
[20] HUANG C S, HUANG C Y, LEE C H, et al. IGFBP2 plays an important role in heat shock protein 27-mediated cancer progression and metastasis[J].Oncotarget,2017,8(33):54978-54992.
[21] GE H, DU J, XU J, et al. SUMOylation of HSP27 by small ubiquitin-like modifier 2/3 promotes proliferation and invasion of hepatocellular carcinoma cells[J].Cancer Biol Ther,2017,18(8):552-559.
[22] YASUDA K, HIROHASHI Y, MARIYA T, et al. Phosphorylation of HSF1 at serine 326 residue is related to the maintenance of gynecologic cancer stem cells through expression of HSP27[J].Oncotarget,2017,8(19):31540-31553.
[23] CHEN W, REN X, WU J, et al. HSP27 associates with epithelial-mesenchymal transition, stemness and radioresistance of salivary adenoid cystic carcinoma[J].Cell Mol Med, 2018,22(4):2283-2298.
[24] MO X M, LI L, ZHU P, et al. Up-regulation of HSP27 by ERα/Sp1 facilitates proliferation and confers resistance to apoptosis in human papillary thyroid cancer cells[J].Mol Cell Endocrinol,2016,431:71-87.
[25] CHOI S H, NAM J K, KIM B Y, et al. HSPB1 inhibits the Endothelial-to-Mesenchymal transition to suppress pulmonary fibrosis and lung tumorigenesis[J].Cancer Res,2016,76(5):1019-1030.
[26] ZHANG Y, TAO X, JIN G, et al. A targetable molecular chaperone HSP27 confers aggressiveness in hepatocellular carcinoma[J].Theranostics,2016,6(4):558-570.
[27] DENG W, ZHANG Y, GU L, et al. Heat shock protein 27 downstream of P38-PI3K/Akt signaling antagonizes melatonin-induced apoptosis of SGC-7901 gastric cancer cells[J].Cancer Cell Int,2016,16:5.
[28] ZHANG S, HU Y, HUANG Y, et al. Heat shock protein 27 promotes cell proliferation through activator protein-1 in lung cancer[J].Oncol Lett,2015,9(6):2572-2576.
[29] ZHANG Y, FENG Z, WANG W, et al. Expression of heat shock protein-27(HSP27) and P38MAPK in esophageal squamous cell carcinoma[J].Med Sci Monit,2017,23:5246-5253.
[30] LEE M S, LEE J, LEE S, et al. Clinical, prognostic, and therapeutic significance of heat shock protein 27 in bladder cancer[J].Oncotarget,2018,9(8):7961-7974.
[31] KAIGORODOVA E V, ZAVYALOVA M V, BYCHKOV V A, et al. Functional state of the HSP27 chaperone as a molecular marker of an unfavorable course of larynx cancer[J].Cancer Biomark,2016,17(2):145-153.
[32] OKUNO M, YASUDA I, ADACHI S, et al. The significance of phosphorylated heat shock protein 27 on the prognosis of pancreatic cancer[J].Oncotarget,2016,7(12):14291-14299.
[33] ISHIDA T, ISHII Y, TSURUTA M, et al. Cetuximab promotes SN38 sensitivity via suppression of heat shock protein 27 in colorectal cancer cells with wild-type RAS[J].Oncol Rep,2017,38(2):926-932.
[34] KONDA J D, OLIVERO M, MUSIANI D, et al. Heat-shock protein 27 (HSP27, HSPB1) is synthetic lethal to cells with oncogenic activation of MET, EGFR and BRAF[J].Mol Oncol,2017,11(6):599-611.
[35] LIU C L, CHEN S F, WU M Z, et al. The molecular and clinical verification of therapeutic resistance via the p38 MAPK-HSP27 axis in lung cancer[J].Oncotarget,2016,7(12):14279-14290.
[36] LU H, SUN C, ZHOU T, et al. HSP27 knockdown increases cytoplasmic p21 and cisplatin sensitivity in ovarian carcinoma cells[J].Oncol Res,2016,23(3):119-128.