四川省肿瘤医院2005～2018年肿瘤住院患者HIV抗体筛查结果分析
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摘要
目的了解四川省肿瘤医院2005～2018年肿瘤住院患者HIV的感染状况和流行特征。方法采用酶联免疫吸附(ELISA)法对我院237472例住院患者进行HIV抗体检测,同时对HIV抗体阳性患者的临床资料进行回顾性分析。结果住院肿瘤患者HIV抗体的总体阳性率为1.42‰(338/237472),其中男性患者HIV抗体阳性检出率为2.18‰(244/111885),女性患者HIV抗体阳性检出率为0.75‰(94/125587),性别差异有统计学意义(P<0.05);年龄组以21～30岁检出率最高2.18‰;病种以头颈病区的头颈部肿瘤所占构成比最大21.89%;职业分布较广,且以农村居民为主(48.57%)。结论住院肿瘤患者HIV感染例数呈逐年上升趋势,以中老年男性为主,并存在病区、病种、职业构成差异的特点,为确保医患安全和防止院内感染,应对住院肿瘤患者HIV进行长期监测。
Objective To understand the HIV status and epidemiological characteristics of tumor inpatients in the Sichuan Cancer Hospital from 2005 to 2018. Methods ELISA analysis was performed on 237,472 inpatients in our hospital by enzyme-linked immunosorbent assay(ELISA). The clinical data of HIV-positive patients were retrospectively analyzed. Results The overall positive rate of HIV antibody in hospitalized patients was 1.42‰(338/237472). The positive rate of HIV antibody in male patients was 2.18‰(244/111885), and the positive rate of HIV antibody in female patients was 0.75‰(94/125587), the gender difference was statistically significant(P<0.05); the age group had the highest detection rate of 2.18‰ from 21 to 30 years old; the head and neck tumors in the head and neck area accounted for the largest ratio of 21.89%; occupation It is widely distributed and is dominated by rural residents(48.57%). Conclusion In order to ensure the safety of doctors and patients and to prevent nosocomial infection, the number of cases of HIV infection in inpatients with tumor showed an increasing trend year by year, mainly in middle-aged and elderly men, and there were differences in disease area, disease type and occupation composition. Long-term monitoring of HIV should be performed in inpatients with tumor.
Objective To understand the HIV status and epidemiological characteristics of tumor inpatients in the Sichuan Cancer Hospital from 2005 to 2018. Methods ELISA analysis was performed on 237,472 inpatients in our hospital by enzyme-linked immunosorbent assay(ELISA). The clinical data of HIV-positive patients were retrospectively analyzed. Results The overall positive rate of HIV antibody in hospitalized patients was 1.42‰(338/237472). The positive rate of HIV antibody in male patients was 2.18‰(244/111885), and the positive rate of HIV antibody in female patients was 0.75‰(94/125587), the gender difference was statistically significant(P<0.05); the age group had the highest detection rate of 2.18‰ from 21 to 30 years old; the head and neck tumors in the head and neck area accounted for the largest ratio of 21.89%; occupation It is widely distributed and is dominated by rural residents(48.57%). Conclusion In order to ensure the safety of doctors and patients and to prevent nosocomial infection, the number of cases of HIV infection in inpatients with tumor showed an increasing trend year by year, mainly in middle-aged and elderly men, and there were differences in disease area, disease type and occupation composition. Long-term monitoring of HIV should be performed in inpatients with tumor.
引文
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[15]梁姝,杨洪,叶黎,等.四川省HIV耐药患者后续治疗效果和影响因素分析[J].预防医学情报杂志,2018,34(7):898-907.
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[17]Cobucci RN,Lima PH,de Souza PC,et al.Assessing the impact of HAART on the incidence of defining and non-defining AIDS cancers among patients with HIV/AIDS:a systematic review[J].J Infect Public Health,2015,8(1):1-10.
[18]李露,罗春香,董超.艾滋病相关肿瘤的研究进展[J].中国临床医生杂志,2018,46(2):140-143.
[19]梁卫平.肿瘤患者的HIV抗体检测结果分析[J].临床医药文献电子杂志,2017,4(21):3964,3966.
[2]Conway DP,Holt M,Couldwell DL,et al.Barriers to HIV testing and characterisitics associated with never testing among gay and bisexual men attending sexual health clinics in Sydney[J].JInt AIDS Soc,2015,18(1):20221.
[3]中国疾病预防控制中心性病艾滋病预防控制中心性病控制中心.2018年8月全国艾滋病性病疫情[J].中国艾滋病性病,2018,24(10):965.
[4]杨兴光,钱跃升,张娜,等.山东省艾滋病流行特征分析[J].中国病原生物学杂志,2018,13(1):68-71.
[5]杨晴,胡强,李菁.2013~2017年江西省≥50岁HIV/AIDS病例流行病学特征[J].应用预防医学,2018,24(5):395-397.
[6]陈宗良,周超,张维,等.重庆市主城区50岁以上HIV/AIDS患者特征分析[J].中华疾病控制杂志,2018,22(12):1278-1282.
[7]中华医学会感染病学分会艾滋病丙肝学组中国疾病预防与控制中心.中国艾滋病诊疗指南(2018版)[J].中国艾滋病性病,2018,24(12):1266-1282.
[8]黄曦悦,石明巧,苟瑜,等.64例HIV/AIDS患者合并肿瘤临床特征分析[J].四川医学,2018,39(7):743-747.
[9]蒋玉娥,李灼琴,杨丽,等.HIV感染相关性肿瘤研究进展[J].医学综述,2014,20(8):1404-1406.
[10]Rubinstein PG,Aboulafia DM,Zloza A.Malignancies in HIV/AIDS:from epidemiology to therapeutic challenges[J].AIDS,2014,28(4):453-465.
[11]Chow EP,Tucker JD,Wong FY,et al.Disparities and Risks of Sexually Transmissible infections Men Who Have Sex with Men in China:A Meta-Analysis and Data Synthesis[J].PLoSONE,2014,9(2):e89959.
[12]杨昊,袁琦,王宇扬,等.四川省HIV阳性男男性行为者社会支持及心理健康[J].四川大学学报(医学版),2018,49(6):966-969.
[13]Shargorodsky J,Bleier BS,Holbrook EH,et al.Outcomes analysis in epistaxis management:development of a therapeutic algorithm[J].Otolaryngol Head Neck Surg,2013,149(3):390-398.
[14]贾婧杰,鲍诗平.HIV/AIDS患者合并耳鼻咽喉头颈外科肿瘤的临床分析(附8例报告)[J].北京医学,2017,39(12):1229-1231.
[15]梁姝,杨洪,叶黎,等.四川省HIV耐药患者后续治疗效果和影响因素分析[J].预防医学情报杂志,2018,34(7):898-907.
[16]邱红恒,陈小龙,胡旺,等.中国流动人口HIV感染状况和相关行为特征的累积Meta分析[J].南昌大学学报(医学版),2018,58(5):47-53.
[17]Cobucci RN,Lima PH,de Souza PC,et al.Assessing the impact of HAART on the incidence of defining and non-defining AIDS cancers among patients with HIV/AIDS:a systematic review[J].J Infect Public Health,2015,8(1):1-10.
[18]李露,罗春香,董超.艾滋病相关肿瘤的研究进展[J].中国临床医生杂志,2018,46(2):140-143.
[19]梁卫平.肿瘤患者的HIV抗体检测结果分析[J].临床医药文献电子杂志,2017,4(21):3964,3966.