基于超声透射法的组织特性谱分析
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摘要
针对生物组织的超声诊断问题,基于超声透射法在生物组织中的传播机理,分析了超声在生物组织中的传输衰减特征与生物组织特性及超声频率参数间的关系,提出了超声波在生物组织中传输衰减的理论计算公式。经过计算比较,实验值与理论计算接近,该理论公式可以应用于对生物组织状况的分析。通过超声透射法对生物组织进行实验检测,证实了理论公式定量评估组织状态的有效性,同时表明基于超声透射法的谱分析对组织的可辨识度高,提高了超声对生物组织结构状态诊断的有效性。
Aiming at the problem of ultrasonic diagnosis of biological tissue,based on the mechanism of propagation in biological tissues of the ultrasonic transmission method,this paper analyzes the relation between the transmission attenuation characteristics of ultrasound in biological tissue,the characteristics of biological tissue,and ultrasonic frequency parameters,and puts forward a set of theoretical calculation formula for the attenuation of ultrasonic transmission in biological tissue. After calculation and comparison,it is found that the experimental value is close to the theoretical calculation,which proves that the theoretical formula can be applied to the analysis of the state of biological tissue. Then,the biological tissue was tested by the ultrasonic transmission method,confirming validity of the quantitative evaluation on the organization state by the theoretical formula,and showing that the spectral analysis based on ultrasonic transmission method has high discernibility for tissues and improves the validity of ultrasound in the diagnosis of biological tissue's structure condition.
Aiming at the problem of ultrasonic diagnosis of biological tissue,based on the mechanism of propagation in biological tissues of the ultrasonic transmission method,this paper analyzes the relation between the transmission attenuation characteristics of ultrasound in biological tissue,the characteristics of biological tissue,and ultrasonic frequency parameters,and puts forward a set of theoretical calculation formula for the attenuation of ultrasonic transmission in biological tissue. After calculation and comparison,it is found that the experimental value is close to the theoretical calculation,which proves that the theoretical formula can be applied to the analysis of the state of biological tissue. Then,the biological tissue was tested by the ultrasonic transmission method,confirming validity of the quantitative evaluation on the organization state by the theoretical formula,and showing that the spectral analysis based on ultrasonic transmission method has high discernibility for tissues and improves the validity of ultrasound in the diagnosis of biological tissue's structure condition.
引文
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[11]LAI Yinan,LUO Jianwei,LIU Xiangdong. Study on interventional ultrasonic thrombus ablation technique[J]. Chinese journal of medical instrumentation,2002,26(1):23-25.
[12]PéREZ-LIVA M,HERRAIZ J L,UDíAS J M,et al. Fullwave attenuation reconstruction in the time domain for ultrasound computed tomography[C]//Proceedings of the13th International Symposium on Biomedical Imaging.Prague,Czech Republic,2016:710-713.
[13]RAMALLI A,GUIDI F,BONI E,et al. A real-time chirpcoded imaging system with tissue attenuation compensation[J]. Ultrasonics,2015,60:65-75.
[2]MOHAMED M M,SHAAT L T,MAHMOUD A N. Propagation of ultrasonic waves through demineralized cancellous bone[J]. IEEE transactions on ultrasonics,ferroelectrics,and frequency control,2003,50(3):279-288.
[3]吕海涛.生物多层组织的声传输特性研究[D].西安:陕西师范大学,2006.
[4]OLIVEIRA D P,SANTOS T Q,MAGGI L E,et al. Ultrasound propagation velocity and acoustic attenuation on agarose phantoms'in three different manufacture techniques[C]//Proceedings of 2014 Pan American Health Care Exchanges. Brasilia,Brazil,2014:1-3.
[5]ABDERRAZEK B,TAREK B. Ultrasonic non-destructive characterization of trabecular bone:Experimental and theoretical prediction of the ultrasonic attenuation[C]//Proceedings of the 2015 3rd International Conference on Control,Engineering&Information Technology. Tlemcen,Algeria,2015:1-6.
[6]沈祥立.影响医用透射式超声断层成像性能指标的关键技术研究[D].哈尔滨:哈尔滨工业大学,2012.
[7]CUCCARO R,MUSACCHIO C,GIULIANO ALBO P A,et al.Acoustical characterization of polysaccharide polymers tissuemimicking materials[J]. Ultrasonics,2015,56:210-219.
[8]KANAYAMA Y,KAMIYAMA N,MARUYAMA K,et al.Real-time ultrasound attenuation imaging of diffuse fatty liver disease[J]. Ultrasound in medicine&biology,2013,39(4):692-705.
[9]章东,郭霞生,马青玉,等.医学超声基础[M].北京:科学出版社,2014.
[10]解卓丽,周浩,郑音飞.非均匀组织医学超声发射声场仿真[J].声学学报,2013,38(6):657-662.
[11]LAI Yinan,LUO Jianwei,LIU Xiangdong. Study on interventional ultrasonic thrombus ablation technique[J]. Chinese journal of medical instrumentation,2002,26(1):23-25.
[12]PéREZ-LIVA M,HERRAIZ J L,UDíAS J M,et al. Fullwave attenuation reconstruction in the time domain for ultrasound computed tomography[C]//Proceedings of the13th International Symposium on Biomedical Imaging.Prague,Czech Republic,2016:710-713.
[13]RAMALLI A,GUIDI F,BONI E,et al. A real-time chirpcoded imaging system with tissue attenuation compensation[J]. Ultrasonics,2015,60:65-75.