基于T管途径的远程胆道造影系统研制及应用
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摘要
目的介绍一种优化的无线胆道造影推注仪,并在动物实验中进行验证。方法通过结构和功能优化,设计并研制优化的无线胆道造影推注仪。将15只实验兔分为5组,分别采用0.01、0.10、0.15、0.50、1.00 mL/s速度注射,均注射3 mL造影剂,观察不同注射速度造影效果及兔肝脏和胆管组织学改变。结果不同造影剂推注速度所得的胆道造影效果不同,当注射速度达到0.15 mL/s时,肝段胆管才能充分显影。但当注射速度达到0.5 mL/s时,肝脏和胆管细胞出现损伤。结论优化的无线胆道造影推注仪操作性强、安全性高,并能为临床胆道造影提供参数选择参考,有望投入临床试用。
Objective To introduce an optimized wireless cholangiography bolus and it was validated in animal experiments. Methods Through the optimization of structure and function, the optimized wireless cholangiography bolus was designed and developed. Fifteen experimental rabbits were divided into 5 groups, which were injected at speed of 0.01,0.10, 0.15, 0.50, 1.00 mL/s, and the injection volume was 3 mL. The effects of contrast angiography and histological changes of the liver and bile duct at different speeds were observed. Results The cholangiography results obtained by different contrast agent bolus speeds were different. When the injection speed was greater than 0.15 mL/s, the liver segment bile duct could be fully developed. However, when the speed was greater than 0.50 mL/s, the liver and biliary cells were damaged. Conclusion The optimized wireless cholangiography bolus is highly operable and safe. It can provide a parameter selection reference for clinical cholangiography, which means it is expected to be put into clinical trials.
Objective To introduce an optimized wireless cholangiography bolus and it was validated in animal experiments. Methods Through the optimization of structure and function, the optimized wireless cholangiography bolus was designed and developed. Fifteen experimental rabbits were divided into 5 groups, which were injected at speed of 0.01,0.10, 0.15, 0.50, 1.00 mL/s, and the injection volume was 3 mL. The effects of contrast angiography and histological changes of the liver and bile duct at different speeds were observed. Results The cholangiography results obtained by different contrast agent bolus speeds were different. When the injection speed was greater than 0.15 mL/s, the liver segment bile duct could be fully developed. However, when the speed was greater than 0.50 mL/s, the liver and biliary cells were damaged. Conclusion The optimized wireless cholangiography bolus is highly operable and safe. It can provide a parameter selection reference for clinical cholangiography, which means it is expected to be put into clinical trials.
引文
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[2]MORRISSEY JF.Cholangiography[J].N Engl J Med,1973,289(5):266-267.
[3]DICK R.Cholangiography-the old versus the new[J].Trans Med Soc Lond,1979,96:69-70.
[4]闵锐.医源性电离辐射损伤及其生物医学防护[J].辐射防护通讯,2013,33(3):8-15.
[5]AMIS ES JR,BUTLER PF,APPLEGATE KE,et al.American college of radiology white paper on radiation dose in medicine[J].J Am Coll Radiol,2007,4(5):272-284.
[6]PEDRO V.Radiation protection and dosimetry issues in the medical applications ionizing radiation[J].Radiat Phys Chem,2014,104:23-30.
[7]HYUN SJ,KIM KJ,JAHNG TA,et al.Efficiency of lead aprons in blocking radiation-how protective are they?[J].Heliyon,2016,2(5):e117.
[8]KLEIN LW,MILLER DL,BALTER S,et al.Occupational health hazards in the interventional laboratory:time for a safer environment[J].Catheter Cardiovasc Interv,2018.
[9]彭亮,霍壁林,谭明华.改良T管造影术的临床应用[J].当代医学,2009,15(16):74-75.
[10]古淑芳.经阴道实时三维子宫输卵管造影中YZ-800造影剂注射装置的应用[D].广州:广州中医药大学,2017.
[11]蔡圣强.重力滴注法T管造影术的临床应用[J].现代中西医结合杂志,2007,16(26):3829-3830.
[12]朱皓阳,董鼎辉,罗禹,等.胆道造影剂远程推注器的研制[J].中国医疗器械杂志,2018,42(1):11-13.
[13]ZHU H,DONG D,LUO Y,et al.A novel remote-controlled injection device for T-tube cholangiography:a feasibility study in canines[J].Med Sci Monit,2019,25:2016-2023.
[14]TAZUMA S,UNNO M,IGARASHI Y,et al.Evidence-based clinical practice guidelines for cholelithiasis 2016[J].J Gastroenterol,2017,52(3):276-300.
[15]SINGH A,MANN HS,THUKRAL CL,et al.Diagnostic accuracy of MRCP as compared to ultrasound/CT in patients with obstructive jaundice[J].J Clin Diagn Res,2014,8(3):103-107.
[16]FRIEBE M.Computed tomography and magnetic resonance imaging contrast media injectors:technical feature review-what is really needed?[J].Med Devices(Auckl),2016,9:231-239.
[17]CHAYA A,JOST G,ENDRIKAT J.Piston-based vs peristaltic pump-based CT injector systems[J].Radiol Technol,2019,90(4):344-352.