骨良性纤维组织细胞瘤及非骨化性纤维瘤临床病理分析及对比研究
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摘要
目的探讨骨良性纤维组织细胞瘤(BFH)与非骨化性纤维瘤(NOF)/纤维性骨皮质缺损(FCD)两者之间在临床、影像学及病理形态学方面的特点及异同。方法回顾性分析及对比16例BFH及48例NOF的临床病理资料,并获取患者预后信息。结果对比BFH与NOF/FCD的发病年龄、性别、好发部位及预后,两者之差异有统计学意义(P=0. 000);而两者临床症状之间差异无统计学意义(P>0. 05),影像学检查两者之间差异无统计学意义(P>0. 05),镜下病理学特征之间差异无统计学意义(P>0. 05)。结论 BFH和NOF是两个独立的疾病,诊断及鉴别诊断有赖于临床、影像及病理组织形态学的三结合,正确的诊断及治疗可以改善或提高其预后。
Objective To investigate the clinical,imaging and pathological features,similarities and differences between benign fibrous histiocytoma( BFH) and non-ossifying fibroma( NOF)/fibrous cortical defect( FCD). Methods The clinical and pathological data of 16 cases of BFH and 48 cases of NOF were retrospectively analyzed and compared.Results The age,gender,predilection and prognosis of BFH and NOF/FCD were statistically significant( P = 0. 000). There was no significant difference in clinical symptoms between the two groups( P>0. 05).There was no significant difference in imaging findings between the two groups( P>0. 05).There was no significant difference in pathological features between the two groups( P>0. 05).Conclusion BFH and NOF are two independent diseases.The diagnosis and differential diagnosis depend on the combination of clinical,imaging and pathological histomorphology.Correct diagnosis and treatment can improve the prognosis.
Objective To investigate the clinical,imaging and pathological features,similarities and differences between benign fibrous histiocytoma( BFH) and non-ossifying fibroma( NOF)/fibrous cortical defect( FCD). Methods The clinical and pathological data of 16 cases of BFH and 48 cases of NOF were retrospectively analyzed and compared.Results The age,gender,predilection and prognosis of BFH and NOF/FCD were statistically significant( P = 0. 000). There was no significant difference in clinical symptoms between the two groups( P>0. 05).There was no significant difference in imaging findings between the two groups( P>0. 05).There was no significant difference in pathological features between the two groups( P>0. 05).Conclusion BFH and NOF are two independent diseases.The diagnosis and differential diagnosis depend on the combination of clinical,imaging and pathological histomorphology.Correct diagnosis and treatment can improve the prognosis.
引文
[1]蒋智铭,张惠箴,郑莉,等.骨关节肿瘤和瘤样病变的病理诊断[M].上海:上海科技教育出版社,2008:100-104.
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[8] Sakamoto A,Tanaka K,Yoshida T,et al.Nonossifying fibroma accompanied by pathological fracture in a 12-year-old runner[J].Journal of Orthopaedic&Sports Physical Therapy,2008,38(7):434-438.
[9] Abdelsayed R A,Sharma S,Ferguson H.Fibrous cortical defect(nonossifying fibroma)of the mandibular ramus:report of 2 cases.[J]. Oral Surgery Oral Medicine Oral Pathology Oral Radiology&Endodontology,2010,110(4):504-508.
[10] Arata MA,Peterson HA,Dahlin DC.Pathological fractures through non-ossifying fibromas.Review of the Mayo Clinic experience[J].Journal of Bone&Joint Surgery American Volume,1981,63(6):980-988.
[11] Roessner A,Immenkamp M,Weidner A,et al.Benign fibrous histiocytoma of bone. Light-and electron-microscopic observations[J]. Journal of Cancer Research&Clinical Oncology,1981,101(2):191-202.
[12] Brassesco MS,Valera ET,Engel EE,et al.Clonal complex chromosome aberration in non-ossifying fibroma[J].Pediatric Blood&Cancer,2010,54(5):764-767.
[2] Christopher D.M.Fletcher,Julia A.Bridge,Pancras C.W.Hogendoorn.WHO classi-fication of tumours of the Soft Tissue and Bone[M].4ed.Lyon:IARC Press,2013:292-293.
[3] Bhople KS,Kulkarni PV,Arora N,et al.Benign fibrous histiocytoma of bone:a case report[J]. Indian Journal of Pathology&Microbiology,2006,49(4):589-91.
[4] Bertoni F,Calderoni P,Bacchini P,et al.Benign fibrous histiocytoma of bone.[J]. Journal of Cancer Research&Clinical Oncology,1981,101(2):191-202.
[5] Matsuno T.Benign fibrous histiocytoma involving the ends of long bone[J].Skeletal Radiology,1990,19(8):561-566.
[6] Clarke BE,Xipell JM,Thomas DP.Benign fibrous histiocytoma of bone[J].American Journal of Surgical Pathology,1985,9(11):806-815.
[7] Glockenberg A,Sobel E,No3l JF.Nonossifying fibroma.Four cases and review of the literature[J]. Journal of the American Podiatric Medical Association,1997,87(2):66.
[8] Sakamoto A,Tanaka K,Yoshida T,et al.Nonossifying fibroma accompanied by pathological fracture in a 12-year-old runner[J].Journal of Orthopaedic&Sports Physical Therapy,2008,38(7):434-438.
[9] Abdelsayed R A,Sharma S,Ferguson H.Fibrous cortical defect(nonossifying fibroma)of the mandibular ramus:report of 2 cases.[J]. Oral Surgery Oral Medicine Oral Pathology Oral Radiology&Endodontology,2010,110(4):504-508.
[10] Arata MA,Peterson HA,Dahlin DC.Pathological fractures through non-ossifying fibromas.Review of the Mayo Clinic experience[J].Journal of Bone&Joint Surgery American Volume,1981,63(6):980-988.
[11] Roessner A,Immenkamp M,Weidner A,et al.Benign fibrous histiocytoma of bone. Light-and electron-microscopic observations[J]. Journal of Cancer Research&Clinical Oncology,1981,101(2):191-202.
[12] Brassesco MS,Valera ET,Engel EE,et al.Clonal complex chromosome aberration in non-ossifying fibroma[J].Pediatric Blood&Cancer,2010,54(5):764-767.