骨形态发生蛋白信号通路在牙根发育中的作用
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摘要
骨形态发生蛋白(BMP)家族是调节细胞生命活动的重要因子,几乎参与了所有组织的发育。BMP介导的信号通路在牙发育过程中发挥十分重要的作用,而牙根发育是牙发育的一部分,是上皮和间充质相互作用的复杂过程。上皮和牙胚间充质中的BMP信号通路在牙根发育中的作用也有所不同,本文综述了BMP信号通路在牙根发育中作用的研究进展。
The bone morphogenetic protein(BMP) family is an important factor in the regulation of cell ular life activities and in the development of almost all tissues. BMP-mediated signaling plays an important role in tooth root development, which is a part of tooth development. Epithelial and mesenchymal interactions are involved in tooth root development, but the BMP signaling pathway has a different effect on tooth root development in epithelial and mesenchymal. This review summarizes the advances of BMP signaling in tooth root development.
The bone morphogenetic protein(BMP) family is an important factor in the regulation of cell ular life activities and in the development of almost all tissues. BMP-mediated signaling plays an important role in tooth root development, which is a part of tooth development. Epithelial and mesenchymal interactions are involved in tooth root development, but the BMP signaling pathway has a different effect on tooth root development in epithelial and mesenchymal. This review summarizes the advances of BMP signaling in tooth root development.
引文
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[2]Rahman MS, Akhtar N, Jamil HM, et al. TGF-β/BMP signaling and other molecular events:regulation of osteoblastogenesis and bone formation[J]. Bone Res, 2015, 3:15005.
[3]Katagiri T, Watabe T. Bone morphogenetic proteins[J]. Cold Spring Harb Perspect Biol, 2016, 8(6). pii:a021899.
[4]WangR,GreenJ, WangZL,etal.Bonemorphogenetic protein(BMP)signaling in development and human diseases[J]. Genes Dis, 2014, 1(1):87-105.
[5]Miyazono K, Kamiya Y, Morikawa M. Bone morphogenetic protein receptors and signal transduction[J]. J Biochem, 2010,147(1):35-51.
[6]Tsukamoto S, Mizuta T, Fujimoto M, et al. Smad9 is a new type of transcriptional regulator in bone morphogenetic protein signaling[J]. Sci Rep, 2014, 4:7596.
[7]Wu MR, Chen GQ, Li YP. TGF-βand BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease[J]. Bone Res, 2016, 4:16009.
[8]Wang M, Jin H, Tang D, et al. Smad1 plays an essential role in bone development and postnatal bone formation[J].Osteoarthr Cartil, 2011, 19(6):751-762.
[9]Gunnell LM, Jonason JH, Loiselle AE, et al. TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways[J]. J Bone Miner Res, 2010, 25(8):1784-1797.
[10]Balic A, ThesleffI. Tissueinteractionsregulatingtooth developmentandrenewal[J].Curr TopDevBiol,2015,115:157-186.
[11]Huang XF, Bringas P, Slavkin HC, et al. Fate of HERS during tooth root development[J]. Dev Biol, 2009, 334(1):22-30.
[12]Mullen LM, Richards DW, Quaranta V. Evidence that laminin-5 is a component of the tooth surface internal basal lamina,supporting epithelial cell adhesion[J]. J Periodont Res, 1999,34(1):16-24.
[13]Kim TH, Bae C, Yang SQ, et al. Nfic regulates tooth root patterning and growth[J]. Anat Cell Biol, 2015, 48(3):188-194.
[14]Roh SY, Park JC. The role of nuclear factor I-C in tooth and bone development[J]. J Korean Assoc Oral Maxillofac Surg,2017, 43(2):63-69.
[15]Nemoto E, Sakisaka Y, Tsuchiya M, et al. Wnt3a signaling induces murine dental follicle cells to differentiate into cementoblastic/osteoblastic cells via an osterix-dependent pathway[J]. J Periodont Res, 2016, 51(2):164-174.
[16]Huang XF, Xu X, Bringas P, et al. Smad4-Shh-Nfic signaling cascade-mediated epithelial-mesenchymal interaction is crucial in regulating tooth root development[J]. J Bone Miner Res, 2010, 25(5):1167-1178.
[17]Liu Y, Feng JF, Li JY, et al. An Nfic-hedgehog signaling cascade regulates tooth root development[J]. Development, 2015, 142(19):3374-3382.
[18]Li JY, Feng JF, Liu Y, et al. BMP-SHH signaling network controls epithelial stem cell fate via regulation of its niche in the developing tooth[J]. Dev Cell, 2015, 33(2):125-135.
[19]A?oub M, Lézot F, Molla M, et al. Msx2-/-transgenic mice develop compound amelogenesis imperfecta, dentinogenesis imperfecta and periodental osteopetrosis[J]. Bone, 2007, 41(5):851-859.
[20]Plikus MV, Zeichner-David M, Mayer JA, et al. Morphoregulation of teeth:modulating the number, size, shape and differentiation by tuning Bmp activity[J]. Evol Dev, 2005,7(5):440-457.
[21]Rakian A, Yang WC, Gluhak-Heinrich J, et al. Bone morphogenetic protein-2 gene controls tooth root development in coordination with formation of the periodontium[J]. Int J Oral Sci, 2013, 5(2):75-84.
[22]LapthanasupkulP,FengJF,Mantesso A,etal.Ring1a/b polycomb proteins regulate the mesenchymal stem cell niche in continuously growing incisors[J]. Dev Biol, 2012, 367(2):140-153.
[23]Feng JF, Jing JJ, Li JY, et al. BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice[J]. Development, 2017, 144(14):2560-2569.
[24]Gao YR, Yang G, Weng TJ, et al. Disruption of Smad4 in odontoblasts causes multiple keratocystic odontogenic tumors and tooth malformation in mice[J]. Mol Cell Biol, 2009, 29(21):5941-5951.
[25]Li JY, Huang XF, Xu X, et al. SMAD4-mediated WNT signaling controls the fate of cranial neural crest cells during tooth morphogenesis[J]. Development, 2011, 138(10):1977-1989.
[26]Yang ZH, Hai B, Qin LZ, et al. Cessation of epithelial Bmp signaling switches the differentiation of crown epithelia to the root lineage in aβ-catenin-dependent manner[J]. Mol Cell Biol, 2013, 33(23):4732-4744.
[27]Zhang R, Teng Y, Zhu L, et al. Odontoblastβ-catenin signaling regulates fenestration of mouse Hertwig’s epithelial root sheath[J]. Sci China Life Sci, 2015, 58(9):876-881.
[28]Yang BN, Sun HL, Song FF, et al. Yes-associated protein 1promotes the differentiation and mineralization of cementoblast[J]. J Cell Physiol, 2018, 233(3):2213-2224.
[29]Dineshshankar J, Sivakumar M, Balasubramanium A, et al.Taurodontism[J]. J Phar Bioal Sci, 2014, 6(5):13.
[30]Foster BL, Nagatomo KJ, Tso HW, et al. Tooth root dentin mineralization defects in a mouse model of hypophosphatasia[J]. J Bone Miner Res, 2013, 28(2):271-282.
[2]Rahman MS, Akhtar N, Jamil HM, et al. TGF-β/BMP signaling and other molecular events:regulation of osteoblastogenesis and bone formation[J]. Bone Res, 2015, 3:15005.
[3]Katagiri T, Watabe T. Bone morphogenetic proteins[J]. Cold Spring Harb Perspect Biol, 2016, 8(6). pii:a021899.
[4]WangR,GreenJ, WangZL,etal.Bonemorphogenetic protein(BMP)signaling in development and human diseases[J]. Genes Dis, 2014, 1(1):87-105.
[5]Miyazono K, Kamiya Y, Morikawa M. Bone morphogenetic protein receptors and signal transduction[J]. J Biochem, 2010,147(1):35-51.
[6]Tsukamoto S, Mizuta T, Fujimoto M, et al. Smad9 is a new type of transcriptional regulator in bone morphogenetic protein signaling[J]. Sci Rep, 2014, 4:7596.
[7]Wu MR, Chen GQ, Li YP. TGF-βand BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease[J]. Bone Res, 2016, 4:16009.
[8]Wang M, Jin H, Tang D, et al. Smad1 plays an essential role in bone development and postnatal bone formation[J].Osteoarthr Cartil, 2011, 19(6):751-762.
[9]Gunnell LM, Jonason JH, Loiselle AE, et al. TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways[J]. J Bone Miner Res, 2010, 25(8):1784-1797.
[10]Balic A, ThesleffI. Tissueinteractionsregulatingtooth developmentandrenewal[J].Curr TopDevBiol,2015,115:157-186.
[11]Huang XF, Bringas P, Slavkin HC, et al. Fate of HERS during tooth root development[J]. Dev Biol, 2009, 334(1):22-30.
[12]Mullen LM, Richards DW, Quaranta V. Evidence that laminin-5 is a component of the tooth surface internal basal lamina,supporting epithelial cell adhesion[J]. J Periodont Res, 1999,34(1):16-24.
[13]Kim TH, Bae C, Yang SQ, et al. Nfic regulates tooth root patterning and growth[J]. Anat Cell Biol, 2015, 48(3):188-194.
[14]Roh SY, Park JC. The role of nuclear factor I-C in tooth and bone development[J]. J Korean Assoc Oral Maxillofac Surg,2017, 43(2):63-69.
[15]Nemoto E, Sakisaka Y, Tsuchiya M, et al. Wnt3a signaling induces murine dental follicle cells to differentiate into cementoblastic/osteoblastic cells via an osterix-dependent pathway[J]. J Periodont Res, 2016, 51(2):164-174.
[16]Huang XF, Xu X, Bringas P, et al. Smad4-Shh-Nfic signaling cascade-mediated epithelial-mesenchymal interaction is crucial in regulating tooth root development[J]. J Bone Miner Res, 2010, 25(5):1167-1178.
[17]Liu Y, Feng JF, Li JY, et al. An Nfic-hedgehog signaling cascade regulates tooth root development[J]. Development, 2015, 142(19):3374-3382.
[18]Li JY, Feng JF, Liu Y, et al. BMP-SHH signaling network controls epithelial stem cell fate via regulation of its niche in the developing tooth[J]. Dev Cell, 2015, 33(2):125-135.
[19]A?oub M, Lézot F, Molla M, et al. Msx2-/-transgenic mice develop compound amelogenesis imperfecta, dentinogenesis imperfecta and periodental osteopetrosis[J]. Bone, 2007, 41(5):851-859.
[20]Plikus MV, Zeichner-David M, Mayer JA, et al. Morphoregulation of teeth:modulating the number, size, shape and differentiation by tuning Bmp activity[J]. Evol Dev, 2005,7(5):440-457.
[21]Rakian A, Yang WC, Gluhak-Heinrich J, et al. Bone morphogenetic protein-2 gene controls tooth root development in coordination with formation of the periodontium[J]. Int J Oral Sci, 2013, 5(2):75-84.
[22]LapthanasupkulP,FengJF,Mantesso A,etal.Ring1a/b polycomb proteins regulate the mesenchymal stem cell niche in continuously growing incisors[J]. Dev Biol, 2012, 367(2):140-153.
[23]Feng JF, Jing JJ, Li JY, et al. BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice[J]. Development, 2017, 144(14):2560-2569.
[24]Gao YR, Yang G, Weng TJ, et al. Disruption of Smad4 in odontoblasts causes multiple keratocystic odontogenic tumors and tooth malformation in mice[J]. Mol Cell Biol, 2009, 29(21):5941-5951.
[25]Li JY, Huang XF, Xu X, et al. SMAD4-mediated WNT signaling controls the fate of cranial neural crest cells during tooth morphogenesis[J]. Development, 2011, 138(10):1977-1989.
[26]Yang ZH, Hai B, Qin LZ, et al. Cessation of epithelial Bmp signaling switches the differentiation of crown epithelia to the root lineage in aβ-catenin-dependent manner[J]. Mol Cell Biol, 2013, 33(23):4732-4744.
[27]Zhang R, Teng Y, Zhu L, et al. Odontoblastβ-catenin signaling regulates fenestration of mouse Hertwig’s epithelial root sheath[J]. Sci China Life Sci, 2015, 58(9):876-881.
[28]Yang BN, Sun HL, Song FF, et al. Yes-associated protein 1promotes the differentiation and mineralization of cementoblast[J]. J Cell Physiol, 2018, 233(3):2213-2224.
[29]Dineshshankar J, Sivakumar M, Balasubramanium A, et al.Taurodontism[J]. J Phar Bioal Sci, 2014, 6(5):13.
[30]Foster BL, Nagatomo KJ, Tso HW, et al. Tooth root dentin mineralization defects in a mouse model of hypophosphatasia[J]. J Bone Miner Res, 2013, 28(2):271-282.