摘要
免疫突触(immunological synapse,IS)是抗原提呈细胞与T细胞免疫识别时,多种分子参与、分阶段不断变化的过程,涉及黏附分子、细胞因子、信号传导分子、细胞骨架蛋白等多分子的聚集或离散.其形成不仅促进T细胞和抗原提呈细胞的稳定接触,而且激活T细胞信号传导途径,促进T细胞的活化和增殖.对IS的研究可以从分子水平解释免疫激活、免疫耐受、病原微生物感染与免疫细胞相互作用的机制,为进一步揭示疾病发生的分子机制,寻求疾病防治的靶向分子提供新的思路.近年来,光学成像的发展为可视化研究IS形成与T细胞活化的关系提供了有力帮助,为研究生理病理状态下的免疫应答提供了有力工具.
Immunological synapse(IS) is a specialized and sophisticated supramolecular activation cluster structure that is formed at the interface between T cell and antigen presenting cells. It is a dynamic multistage progress, involving adhesion molecules, cytokines, signaling molecules, cell cytoskeletal proteins and other molecules. IS is not only contribute to the stability of the contact between T cells and APC, but also promotes T-cell activation and proliferation through T cells signaling pathway. Studying of the immunological synapse could explain molecular mechanisms of immune activation, immune tolerance, and the mechanism of interaction between pathogenic microbes and immune cells, which will provide new ideas for further revealing the pathogenic mechanism of disease, and seeking new target molecules for disease control and prevention. Recently, optical imaging provides a powerful help for visualization on the relationship between IS formation and T-cell activation.It provides a powerful tool for studying the immune response under physiological and pathological conditions.
引文
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