摘要
桥尾蛋白(gephyrin)是第一个被发现的抑制性突触后膜骨架蛋白,也是中枢神经系统抑制性突触的突触后蛋白网络的重要组成部分。近年研究表明,桥尾蛋白在抑制性突触形成、稳定抑制性突触后膜受体、调节突触可塑性方面具有重要作用,桥尾蛋白异常可能与钼辅因子(MoCo)缺乏症、阿尔茨海默病(AD)、癫痫等神经系统疾病有关。本文综述了桥尾蛋白的结构、功能及其与神经系统疾病的关系,以期为早期预防、干预甚至治愈相关神经系统疾病提供参考。
Gephyrin,as the first founded inhibitory postsynaptic skeletal protein,is an important component of postsynaptic protein network of inhibitory synapse in central nervous system. In recent years,many studies showed that,gephyrin plays an important role in formation of inhibitory synapse,stabilization of inhibitory synaptic receptors and adjustment of synaptic plasticity,abnormality of gephyrin may correlated some nervous system disease,such as molybdenum cofactor deficiency,Alzheimer's disease and epilepsy. This paper mainly reviewed the structure,function of gephyrin and its relation with nervous system disease,to provide a reference for early prevention,intervention and even cure of nervous system disease.
引文
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