骨髓相关蛋白与动脉粥样硬化性心脏病关系的研究进展
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摘要
急性冠状动脉综合征是心血管科的危急重症,冠状动脉粥样硬化斑块破裂或腐蚀继发血栓形成是急性冠状动脉事件发生的病理基础。新近研究发现,骨髓相关蛋白(MRP)8/14由炎性细胞分泌,参与动脉粥样硬化斑块的发生与发展,是冠状动脉粥样硬化性心脏病患者发生心血管不良事件的预测因子。研究MRP8/14的生物学特性及其与心血管事件的关系,可为临床诊断和治疗带来新的思路。
Acute coronary syndrome is a severe crisis of the Cardiovascular Division.Pathological studies have demonstrated that disruption or erosion of atherosclerotic plaques and subsequent thromboses are the most important cause of acute coronary events.Recently,a biomarker of myeloid-related protein 8 /14(MRP8 / 14) is secreted by inflammatory cells and is involved in the occurrence and development of the atherosclerotic plaque,and could be a predictor of adverse cardiovascular events in patients with coronary heart disease.The present article focuses on the biologic characteristics of MRP8 /14 and the relationship between MRP8 /14 and cardiovascular diseases,which may bring new ideas for the clinical diagnosis and treatment.
Acute coronary syndrome is a severe crisis of the Cardiovascular Division.Pathological studies have demonstrated that disruption or erosion of atherosclerotic plaques and subsequent thromboses are the most important cause of acute coronary events.Recently,a biomarker of myeloid-related protein 8 /14(MRP8 / 14) is secreted by inflammatory cells and is involved in the occurrence and development of the atherosclerotic plaque,and could be a predictor of adverse cardiovascular events in patients with coronary heart disease.The present article focuses on the biologic characteristics of MRP8 /14 and the relationship between MRP8 /14 and cardiovascular diseases,which may bring new ideas for the clinical diagnosis and treatment.
引文
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[23]Vora AN,Bonaca MP,Ruff CT,et al.Diagnostic evaluation of theMRP-8/14 for the emergency assessment of chest pain[J].JThromb Thrombolysis,2012,34(2):229-234.
[24]Dekker MS,Mosterd A,van't Hof AW,et al.Novel biochemicalmarkers in suspected acute coronary syndrome:systematic reviewand critical appraisal[J].Heart,2010,96(13):1001-1010.
[2]Skubitz KM,Christiansen NP,Mendiola JR.Preparation and char-acterization of monoclonal antibodies to human neutrophil cathepsinG,lactoferrin,eosinophil peroxidase,and eosinophil major basicprotein[J].J Leukoc Biol,1989,46(2):109-118.
[3]Zimmer DB,Cornwall EH,Landar A,et al.The S100 proteinfamily:history,function,and expression[J].Brain Res Bull,1995,37(4):417-429.
[4]Hogg N,Allen C,Edgeworth J.Monoclonal antibody 5.5 reactswith p8,14,a myeloid molecule associated with some vascularendothelium[J].Eur J Immunol,989,19(16):1053-1061.
[5]Hessian PA,Edqeworth J,Hoqq N.MRP-8 and MRP-14,two abun-dant Ca2+-binding proteins of neutrophils and monocytes[J].JLeukoc Biol,993,53(2):197-204.
[6]Edqeworth J,Gorman M,Bennett R,et al.Identification of p8,14 asa highly abundant heterodimeric calcium binding protein complex ofmyeloid cells[J].J Biol Chem,1991,266(12):7706-7713.
[7]Stroncek DF,Shankar RA,Skubitz KM.The subcellular distribu-tion of myeloid-related protein 8(MRP8)and MRP14 in humanneutrophils[J].J Transl Med,2005,3:36.
[8]Healy AM,Pickard MD,Pradhan AD,et al.Platelet expression pro-filing and clinical validation of myeloid-related protein-14 as anovel determinant of cardiovascular events[J].Circulation,2006,113(19):2278-2284.
[9]Vora AN,Bonaca MP,Ruff CT,et al.Diagnostic evaluation of theMRP8/14 for the emergency assessmen of chest pain[J].J ThrombThrombolysis,2012,34(2):229-234.
[10]Loser K,Vogl T,Voskort M,et al.The toll-like receptor 4 ligandsMrp8 and Mrp14 are crucial in the development of autoreactiveCD8+T cells[J].Nat Med,2010,16(6):713-717.
[11]Kerkhoff C,Sorg C,Tandon NN,et al.Interaction of S100A8/S100A9-arachidonic acid complexes with the scavenger receptorCD36 may facilitate fatty acid uptake by endothelial cells[J].Biochemistry,2001,40(1):241-248.
[12]Shimizu K,Libby P,Rocha VZ,et al.Loss of myeloid related pro-tein-8/14 exacerbates cardiac allograft rejection[J].Circulation,2011,124(25):2920-2932.
[13]Ross R.Atherosclerosis:an inflammatory disease[J].N Engl JMed,1999,340(2):115-126.
[14]Wu X,Maehara A,Mintz GS,et al.Virtual histology intravascularultrasound analysis of non-culprit attenuated plaques detectedbygrayscale intravascular ultrasound in patients with acute coronarysyndromes[J].Am J Cardiol,2010,105(1):48-53.
[15]Ionita MG,Vink A,Dijke IE,et al.High levels of myeloid-relatedprotein 14 in human atherosclerotic plaques correlate with the char-acteristics of rupture-prone lesions[J].Arterioscler Thromb VascBiol,2009,29(8):1220-1227.
[16]Ionita MG,Catanzariti LM,Bots ML,et al.High myeloid-relatedprotein:8/14 levels are related to an increased risk of cardiovascu-lar events after carotid endarterectomy[J].Stroke,2010,41(9):2010-2015.
[17]Croce K,Gao H,Wang Y,et al.Myeloid-related protein-8/14 iscritical for the biological response to vascular injury[J].Circula-tion,2009,120(5):427-436.
[18]Altwegg LA,Neidhart M,Hersberger M,et al.Myeloid-related pro-tein 8/14 complex is released by monocytes and granulocytes at thesite of coronary occlusion:a novel,early,and sensitive marker ofacute coronary syndromes[J].Eur Heart J,2007,28(8):941-948.
[19]张永军,汤圣兴.生化标志物联合检测对急性冠脉综合征早期诊断的意义[J].皖南医学院学报,2011,30(5):365-367.
[20]Morrow DA,Wang Y,Groce K,et al.Myeloid-related protein 8/14and the risk of cardiovascular death or myocardial infarction afteran acute coronary syndrome in the pravastatin or atorvastatin evalu-ation and infection Theraphy:thrombolysis in myocardial infarction(PROVE IT-TIMI 22)trial[J].Am Heart J,2008,155(1):49-55.
[21]Maiseyeu A,Badgeley MA,Kampfrath T,et al.In vivo targeting ofinflammation-associated myeloid-related protein 8/14 via gadolini-um immunonanoparticles[J].Arterioscler Thromb Vasc Biol,2012,32(4):962-970.
[22]Yonekawa K,Neidhart M,Altweqq M,et al.Myeloid related pro-teins activate Toll-like receptor 4 in human acute coronary syn-dromes[J].Atherosclerosis,2011,218(2):486-492.
[23]Vora AN,Bonaca MP,Ruff CT,et al.Diagnostic evaluation of theMRP-8/14 for the emergency assessment of chest pain[J].JThromb Thrombolysis,2012,34(2):229-234.
[24]Dekker MS,Mosterd A,van't Hof AW,et al.Novel biochemicalmarkers in suspected acute coronary syndrome:systematic reviewand critical appraisal[J].Heart,2010,96(13):1001-1010.