血小板/淋巴细胞比率(PLR)和中性粒细胞/淋巴细胞比率(NLR)在评估强直性脊柱炎疾病活动度中的价值
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摘要
目的探讨血小板/淋巴细胞比率(PLR)和中性粒细胞/淋巴细胞比率(NLR)在评估强直性脊柱炎疾病活动度中的价值。方法选择河南科技大学第一附属医院2015年4月至2018年2月收治的60例AS患者作为观察组,依据AS疾病活动性评分ASDA将AS观察组分为活动期AS组和缓解期AS组,另选择同期体检的60例健康者作为对照组,收集相应的临床资料和实验室数据。比较两组研究对象的PLR、NLR、ESR、CRP水平;观察不同疾病活动度组的PLR、NLR、ESR、CRP水平;并对PLR、NLR与ASDAS行相关性分析。结果观察组患者PLR(218±95)、NLR(2.8±1.0)显著高于对照组(P<0.05);活动期AS组患者PLR(312±78)、NLR(3.8±2.4)、ESR、CRP均明显高于缓解期组(P<0.05);AS患者外周血PLR、NLR与疾病活动度评分ASDAS呈正相关。结论 PLR、NLR在AS患者中明显升高,而且与AS病情活动度指标ASDAS相关,对AS疾病活动度评估有一定价值。
引文
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[3]Mercan R,Bitik B,Tufan A,et al.The association between neutrophil/lymphocyte ratio and disease activity in rheumatoid arthritis and ankylosing spondylitis[J].Clin Lab Anal,2016,30(5):597-602.
[4]Safak S,Uslu AU,Serdal K,et al.Association between mean platelet volume levels and inflammation in SLE patients presented with arthritis[J].Afr Health Sci,2014(14):919-924.
[5]Qin B,Ma N,Tang Q,et al.Neutrophil to lymphocyte ratio(NLR)and platelet to lymphocyte ratio(PLR)were useful markers in assessment of inflammatory response and disease activity in SLE patients[J].Mod Rheumatol,2016(26):372-376.
[6]Soydinc S,Turkbeyler IH,Pehlivan Y,et al.Mean platelet volume seems to be a valuable marker in patients with systemic sclerosis[J].Inflammation,2014(37):100-106.
[7]Rifaioglu EN,Bülbül Sen B,Ekiz,et al:Neutrophil to lymphocyte ratio in Behcet’s disease as a marker of disease activity[J].Acta Dermatovenerol Alp Pannonica Adriat,2014(23):65-67.
[8]于刚,张江林.强直性脊柱炎的治疗指南介绍[J].中国骨与关节杂志,2014(10):763-766.
[9]van der Heijde D,Joshi A,Pangan A L,et al.ASAS40and ASDAS clinical responses in the ABILITY-1 clinical trial translate to meaningful improvements in physical function,health-related quality of life and work productivity in patients with non-radiographic axial spondyloarthritis[J].Rheumatology(Oxford),2016,55(1):80-88.
[10]Canpolat F,Akplnar H,Eskio4lu F.Mean platelet volume in psoriasis and psoriatic arthritis.[J].Clin Rheumatol,2010(29):325-328.
[11]Acikgoz N,Karincaoglu Y,Ermis N,et al.Increased mean platelet volume in Behcet’s disease with thrombotic tendency[J].Tohoku J Exp Med,2010(221):119-123.
[12]Templeton AJ,McNamara MG,eruga B,et al.Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors:a systematic review and meta-analysis[J].J Natl Cancer Inst,2014,106(6):dju124.
[13]Shin Ho-Cheol,Jang Jae-Sik,Jin Han-Young,et al.Combined Use of Neutrophil to Lymphocyte Ratio and C-Reactive Protein Level to Predict Clinical Outcomes in Acute Myocardial Infarction Patients Undergoing Percutaneous Coronary Intervention[J].Korean Circ J,2017,47(3):383-391.
[14]Qin Baodong,Ma Ning,Tang Qingqin et al.Neutrophil to lymphocyte ratio(NLR)and platelet to lymphocyte ratio(PLR)were useful markers in assessment of inflammatory response and disease activity in SLE patients[J].Mod Rheumatol,2016,26(3):372-376.
[15]Oh J S,Doh J W,Shim J J,et al.Leading a Patient of Ankylosing Spondylitis to Death by Iatrogenic Spinal Fracture[J].Korean J Spine,2016,13(2):80-82.
[16]Hobbs KF,Cohen MD.Rheumatoid arthritis disease measurement:A new old idea[J].Rheumatology(Oxford),2012,51(6):21-27.
[17]Colglazier CL,Sutej PG.Laboratory testing in the rheumatic diseases:A practical review.[J].South Med,2005(98):185-191.
[18]Pedersen SJ,Srensen IJ,Hermann KG,et al.Responsiveness of the Ankylosing Spondylitis Disease Activity Score(ASDAS)and clinical and MRI measures of disease activity in a 1-year follow-up study of patients with axial spondyloarthritis treated with tumour necrosis factor alpha inhibitors[J].Ann Rheum Dis,2010,69(6):1065-1071.