摘要
目的探讨头孢他啶联合氨溴索治疗老年2型糖尿病(type 2 diabetes mellitus,T2DM)并肺部感染疗效及对血清T淋巴细胞亚群的影响。方法通过对资阳市第一人民医院2016年11月—2017年11月就诊治疗的120例老年T2DM并肺部感染患者临床资料做回顾性分析。根据治疗方式的不同分为观察组、对照组,各60例,对照组给予头孢噻肟钠联合氨溴索治疗,观察组给予头孢他啶联合氨溴索治疗。比较2组患者治疗疗效、不良反应发生情况及治疗前后的白细胞计数(WBC)、C-反应蛋白(C-reactive protein,CRP)、血清T淋巴细胞亚群水平。结果观察组的治疗总有效率高于对照组(χ~2=4.675,P=0.031);治疗后2组患者WBC、CR P水平均较治疗前降低(P<0.05),且观察组WBC、CR P水平较对照组下降明显;治疗后对照组CD3~+、CD8~+、CD4~+/CD8~+水平与治疗前比较差异无统计学意义(P>0.05),观察组CD3~+、CD4~+/CD8~+水平较治疗前上升,CD8~+水平较治疗前下降(P<0.05),观察组治疗后CD3~+、CD4~+/CD8~+水平较对照组上升,CD8~+水平较对照组下降(P<0.05);2组患者不良反应总发生率比较差异无统计学意义(χ~2=0.120,P=0.729)。结论头孢他啶联合氨溴索治疗老年T2DM并肺部感染患者临床疗效显著,可有效的抑制炎性因子表达,调节血清T淋巴细胞亚群水平,且安全可靠。
Objective To investigate the therapeutic effect of ceftazidime combined with ambroxol in the treatment of elderly type 2 diabetes complicated with pulmonary infections and its effect on serum T lymphocyte subsets. Methods The clinical data of 120 elderly patients with T2DM and pulmonary infections treated in our hospital between November 2016 and November 2017 was analyzed retrospectively. These patients were divided into the observation group(60 cases) and control group(60 cases) according to the treatment methods. The control group was given cefotaxime sodium combined with ambroxol, while the observation group was given ceftazidime combined with ambroxol. The efficacy, rate of adverse reactions and levels of WBC, CRP and serum T lymphocyte subsets before and after treatment were compared between the two groups. Results The total effective rate of treatment in the observation group was higher than that of the control group(X~2=4.675, P=0.031). After treatment, the levels of WBC and CRP in the two groups were lower(P<0.05), especially in the observation group. After treatment, the levels of CD8~+, CD4~+/CD8~+ and CD3~+ in the control group hardly changed(P>0.05). The levels of CD4~+/CD8~+ and CD34~+ in the observation group increased after treatment, while the CD8~+ level decreased(P<0.05), The levels of CD4/CD8~+ and CD3~+ in the observation group were higher than those in the control group, while the levels of CD8~+were lower(P<0.05). The total incidence of adverse reactions in the two groups was not significantly different(X~2=0.120, P=0.729). Conclusion Ceftazidime combined with ambroxol is effective in the treatment of elderly patients with T2DM and pulmonary infections. It can effectively inhibit the expression of inflammatory factors and regulate the level of T lymphocyte subsets in serum, and it is safe and reliable.
引文
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