摘要
目的研究卵巢癌患者外周血miR-31表达量与血清肿瘤标志物、基质金属蛋白酶(MMPs)的相关性。方法选取2015年3月-2018年12月宁波市妇女儿童医院手术切除并经术后病理诊断的卵巢癌患者24例作为卵巢癌组,同期在该院体检的健康志愿者24例作为对照组。采集外周血及卵巢癌组织、癌旁组织,抽提miRNA后测定miR-31的表达量;采集血清并测定肿瘤标志物、MMPs的含量。结果卵巢癌组外周血中miR-31的表达量均明显低于对照组(P<0. 05),卵巢癌组织中miR-31的表达量均明显低于癌旁组织(P<0. 05),且卵巢癌患者外周血中miR-31的表达量与卵巢癌组织中miR-31的表达量呈正相关关系(P<0. 05)。卵巢癌组患者血清中CA50、CA125、CA199、组织多肽抗原(TPA)、MMP2、MMP7、MMP9、MMP10的含量均明显高于对照组(P<0. 05),且与外周血中miR-31的表达量呈负相关关系(P<0. 05)。结论卵巢癌患者外周血miR-31的低表达与病灶内miR-31表达量的下调相关且能反应肿瘤标志物、MMPs的变化。
引文
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