经直肠超声电导联合纳米银凝胶治疗Ⅲ型前列腺炎的临床疗效研究
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摘要
目的探讨经直肠超声电导联合纳米银凝胶治疗Ⅲ型前列腺炎的临床疗效。方法选取我院收治的Ⅲ型前列腺炎患者128例,随机分为治疗组64例和对照组64例。治疗组予以经直肠超声导入左氧氟沙星+纳米银凝胶。对照组予以口服左氧氟沙星。观察2组临床疗效、主要症状改善时间,检测尿液中前列腺小体外泄蛋白(PSPE)ELISA方法检测的阳性率及NIH-CPSI。结果治疗组总有效率为92.19%优于对照组的68.75%。治疗组骨盆疼痛、会阴坠胀、阴囊潮湿改善时间均低于对照组(P<0.05)。治疗后治疗组NIH-CPSI疼痛评分、排尿症状评分、生活质量评分及总分与对照组比较(P<0.05)。结论经直肠超声电导联合纳米银凝胶可提高Ⅲ型前列腺炎患者的临床疗效,可明显改善临床症状。
Objective To study the clinical study of transrectal levofloxacin in the treatment of type Ⅲ prostatitis by ultrasoundguided prostate treatment instrument. Methods One hundred and twenty-eight patients with type Ⅲ prostatitis were randomly divided into treatment group(64 cases) and control group(64 cases). The treatment group was given levofloxacin + nano silver gel through transrectal ultrasound. The control group was given levofloxacin orally. The clinical efficacy and improvement time of main symptoms were observed. The positive rate of urinary(PSPE) ELISA and NIH-CPSI were detected. Results The total effective rate of the treatment group was 92.18%, which was better than 68.75% of the control group. The improvement time of pelvic pain, perineal swelling and scrotal humidity in the treatment group was lower than that in the control group(P<0.05). After treatment, the NIHCPSI pain score, urination symptom score, quality of life score and total score of the treatment group were compared with those of the control group(P<0.05). Conclusion Ultrasonic conductance by transrectal ultrasound import levofloxacin in the treatment of type Ⅲ prostatitis can effectively improve the clinical symptoms in patients with CPPS-Ⅲ, and curative effect is stable.
Objective To study the clinical study of transrectal levofloxacin in the treatment of type Ⅲ prostatitis by ultrasoundguided prostate treatment instrument. Methods One hundred and twenty-eight patients with type Ⅲ prostatitis were randomly divided into treatment group(64 cases) and control group(64 cases). The treatment group was given levofloxacin + nano silver gel through transrectal ultrasound. The control group was given levofloxacin orally. The clinical efficacy and improvement time of main symptoms were observed. The positive rate of urinary(PSPE) ELISA and NIH-CPSI were detected. Results The total effective rate of the treatment group was 92.18%, which was better than 68.75% of the control group. The improvement time of pelvic pain, perineal swelling and scrotal humidity in the treatment group was lower than that in the control group(P<0.05). After treatment, the NIHCPSI pain score, urination symptom score, quality of life score and total score of the treatment group were compared with those of the control group(P<0.05). Conclusion Ultrasonic conductance by transrectal ultrasound import levofloxacin in the treatment of type Ⅲ prostatitis can effectively improve the clinical symptoms in patients with CPPS-Ⅲ, and curative effect is stable.
引文
[1]Zhang R,Sutcliffe S,Giovannucci E,et al.Lifestyle and risk of chronic prostatitis/chronic pelvic pain syndrome in a cohort of united states male health professionals[J].J Urol,2015,194(5):1295-1300.
[2]王书杰,张宇.银离子消毒剂的杀菌作用、机制、影响因素及应用[J].中国感染控制杂志,2007,6(3):214-216.
[3]Schaeffer EM.Re:effectiveness of acupuncture on chronic prostatitis-chronic pelvic pain syndrome categoryⅢB patients:a prospective,randomized,nonblinded,clinical trial[J].J Urol,2015,194(4):1007-1008.
[4]Kobayashi I,Ikawa K,Nakamura K,et al.Penetration of piperacillintazobactam into human prostate tissue and dosing considerations for prostatitis based on site-specific pharmacokinetics and pharmacodynamics[J].JInfect Chemother,2015,21(8):575-580.
[5]那彦群.中国泌尿外科疾病诊断治疗指南(2014版)[M].北京:人民卫生出版社,2014:435-445.
[6]Aalberts M,Stout TA,Stoorvogel W.Prostasomes:extracellular vesicles from the prostate[J].Reproduction,2014,147(1):R11-14.
[7]宫满成,董文静,丘少鹏,等.超声电导靶向导入头孢菌素治疗慢性前列腺炎80例的临床分析[J].现代生物医学进展,2016,16(5):864-867.
[8]张峰,阿斯木江·阿不拉,张立东.组织学前列腺炎对良性前列腺增生、前列腺癌患者临床特点的影响[J].中华男科学杂志,2014,20(4):354-358.
[9]肖勇,刘鹏,江立富,等.前列舒颗粒联用氧氟沙星治疗慢性前列腺炎的疗效观察[J].中国现代应用药学,2016,33(2):223-227.
[10]方小龙,陈湘,陈志,等.双倍剂量盐酸坦洛新缓释片治疗Ⅲ型前列腺炎的疗效和安全性分析[J].中华泌尿外科杂志,2015,36(5):354-356.
[11]李冲,王娟,曹文娟,等.坦索罗辛和硝苯地平治疗输尿管下段结石疗效比较的荟萃分析[J].中华泌尿外科杂志,2015,36(11):847-853.
[12]宁克勤,周玉春,樊千,等.中药灌肠耦合汤剂联合超声电导透药治疗Ⅲ型前列腺炎临床观察[J].辽宁中医药大学学报,2013,15(5):10-12.
[13]林成仁,王敏,刘建勋.前列安栓在大鼠体内的药代动力学研究[J].中华男科学,2000,6(2):107-110.
[14]Peeters M,Guliano F.Central neurophysiology and dopaminergic control of ejaculation[J].Neurosci Biobehav Rev,2008,32(3):438-453.
[15]张湜,狄贵娟,张赟,等.合并慢性前列腺炎的良性前列腺增生患者下尿路症状特点[J].中国老年学杂志,2014,34(20):5872-5873.
[2]王书杰,张宇.银离子消毒剂的杀菌作用、机制、影响因素及应用[J].中国感染控制杂志,2007,6(3):214-216.
[3]Schaeffer EM.Re:effectiveness of acupuncture on chronic prostatitis-chronic pelvic pain syndrome categoryⅢB patients:a prospective,randomized,nonblinded,clinical trial[J].J Urol,2015,194(4):1007-1008.
[4]Kobayashi I,Ikawa K,Nakamura K,et al.Penetration of piperacillintazobactam into human prostate tissue and dosing considerations for prostatitis based on site-specific pharmacokinetics and pharmacodynamics[J].JInfect Chemother,2015,21(8):575-580.
[5]那彦群.中国泌尿外科疾病诊断治疗指南(2014版)[M].北京:人民卫生出版社,2014:435-445.
[6]Aalberts M,Stout TA,Stoorvogel W.Prostasomes:extracellular vesicles from the prostate[J].Reproduction,2014,147(1):R11-14.
[7]宫满成,董文静,丘少鹏,等.超声电导靶向导入头孢菌素治疗慢性前列腺炎80例的临床分析[J].现代生物医学进展,2016,16(5):864-867.
[8]张峰,阿斯木江·阿不拉,张立东.组织学前列腺炎对良性前列腺增生、前列腺癌患者临床特点的影响[J].中华男科学杂志,2014,20(4):354-358.
[9]肖勇,刘鹏,江立富,等.前列舒颗粒联用氧氟沙星治疗慢性前列腺炎的疗效观察[J].中国现代应用药学,2016,33(2):223-227.
[10]方小龙,陈湘,陈志,等.双倍剂量盐酸坦洛新缓释片治疗Ⅲ型前列腺炎的疗效和安全性分析[J].中华泌尿外科杂志,2015,36(5):354-356.
[11]李冲,王娟,曹文娟,等.坦索罗辛和硝苯地平治疗输尿管下段结石疗效比较的荟萃分析[J].中华泌尿外科杂志,2015,36(11):847-853.
[12]宁克勤,周玉春,樊千,等.中药灌肠耦合汤剂联合超声电导透药治疗Ⅲ型前列腺炎临床观察[J].辽宁中医药大学学报,2013,15(5):10-12.
[13]林成仁,王敏,刘建勋.前列安栓在大鼠体内的药代动力学研究[J].中华男科学,2000,6(2):107-110.
[14]Peeters M,Guliano F.Central neurophysiology and dopaminergic control of ejaculation[J].Neurosci Biobehav Rev,2008,32(3):438-453.
[15]张湜,狄贵娟,张赟,等.合并慢性前列腺炎的良性前列腺增生患者下尿路症状特点[J].中国老年学杂志,2014,34(20):5872-5873.