低频重复经颅磁刺激联合盐酸氟西汀控制维持期强迫症患者症状的疗效观察
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摘要
目的:观察低频重复经颅磁刺激(r TMS)联合盐酸氟西汀控制维持期强迫症患者症状的疗效。方法:选取112例维持期强迫症的患者作为观察对象,按随机数字表法将所有患者分为对照组(n=56)和研究组(n=56)。对照组患者给予盐酸氟西汀治疗,研究组患者给予低频重复经颅磁刺激(rTMS)联合盐酸氟西汀治疗,采用耶鲁布朗强迫症状量表(Y-BOCS)、抑郁自评量表(SDS)、焦虑自评量表(SAS)评定疗效、不良反应量表(TESS)评分比较两组治疗后不良反应情况及治疗前后各项评分情况。结果:两组患者治疗前耶鲁布朗强迫症状量表(Y-BOCS)、抑郁自评量表(SDS)、焦虑自评量表(SAS)评分比较,差异无统计学意义(P>0.05);治疗后除对照组SDS评分外,其他评分均显著降低,与治疗前比较,差异均有统计学意义(P<0.05)。两组患者治疗后TESS评分比较,差异无统计学意义(P>0.05)。结论:低频重复经颅磁刺激联合盐酸氟西汀控制维持期强迫症患者症状的疗效优于单纯盐酸氟西汀治疗疗效。
Objective: To analyze effects of low-frequency repetitive transcranial magnetic stimulation(rTMS) combined with Fluoxetine hydrochloride on controlling the symptoms of patients with obsessive-compulsive disorders during the maintenance period. Methods: A total of 112 patients with obsessive-compulsive disorders, who were treated in our hospital from December 2014 to May 2017, were selected as the study subjects. All patients were divided into control group(n=56 cases) and study group(n=56 cases) according to the random number table method. The control group was treated with Fluoxetine hydrochloride, while the study group was treated with low-frequency rTMS combined with Fluoxetine hydrochloride. The curative effects were evaluate with the Yale-Brown obsessive-compulsive symptom scale(Y-BOCS), self-rating depression scale(SDS) and self-rating anxiety scale(SAS). The adverse reactions were assessed with the treatment emergent symptom scale(TESS). The scores of the two groups before and after the treatment were compared. Results: There were no significant differences in the Y-BOCS, SDS and SAS scores before the treatment between the two groups(P>0.05). After the treatment, except for the SDS score of the control group, the other scores were significantly lower than those before the treatment, and the differences were statistically significant(P<0.05). Conclusions: Low-frequency rTMS combined with Fluoxetine hydrochloride is superior to single Fluoxetine hydrochloride in controlling the symptoms of the patients with obsessive-compulsive disorders during the maintenance period.
Objective: To analyze effects of low-frequency repetitive transcranial magnetic stimulation(rTMS) combined with Fluoxetine hydrochloride on controlling the symptoms of patients with obsessive-compulsive disorders during the maintenance period. Methods: A total of 112 patients with obsessive-compulsive disorders, who were treated in our hospital from December 2014 to May 2017, were selected as the study subjects. All patients were divided into control group(n=56 cases) and study group(n=56 cases) according to the random number table method. The control group was treated with Fluoxetine hydrochloride, while the study group was treated with low-frequency rTMS combined with Fluoxetine hydrochloride. The curative effects were evaluate with the Yale-Brown obsessive-compulsive symptom scale(Y-BOCS), self-rating depression scale(SDS) and self-rating anxiety scale(SAS). The adverse reactions were assessed with the treatment emergent symptom scale(TESS). The scores of the two groups before and after the treatment were compared. Results: There were no significant differences in the Y-BOCS, SDS and SAS scores before the treatment between the two groups(P>0.05). After the treatment, except for the SDS score of the control group, the other scores were significantly lower than those before the treatment, and the differences were statistically significant(P<0.05). Conclusions: Low-frequency rTMS combined with Fluoxetine hydrochloride is superior to single Fluoxetine hydrochloride in controlling the symptoms of the patients with obsessive-compulsive disorders during the maintenance period.
引文
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[2]韩春芳,姜登发.低频重复经颅磁刺激联合氟伏沙明控制维持期强迫症患者症状的疗效观察[J].精神医学杂志,2015,28(6):446-448.
[3]张清清.氟伏沙明联合无抽搐电休克或喹硫平治疗难治性强迫症[J].中国实用神经疾病杂志,2017,20(17):71-73.
[4]温东玲.氟伏沙明联合无抽搐电休克治疗难治性抑郁症疗效观察[J].中国实用医药,2011,6(7):142-143.
[5]白凤凤,李涛.阿立哌唑联合氟伏沙明治疗难治性强迫症的临床对照研究[J].天津药学,2014,26(3):22-25.
[6]康瑞,康永兵.无抽搐电休克与喹硫平联合氟伏沙明治疗难治性强迫症的疗效比较[J].中国实用神经疾病杂志,2016,19(11):65-66.
[7]梁炜,张迎黎,吕路线.重复经颅磁刺激合并药物治疗强迫症的临床观察[J].中国神经精神疾病杂志,2011,37(7):389.
[8]唐锴,叶庆红,陈志斌,等.无抽搐电休克联合文拉法辛缓释片治疗强迫症对照研究[J].中国医药导报,2012,9(8):88-91.
[9]郝红,赵宁民,朱雪萍,等.氟伏沙明联合阿立哌唑对强迫症患者临床症状及认知功能的影响[J].国际精神病学杂志,2017,44(2):243-246.