艾灸治疗类风湿关节炎的研究概况
|
摘要
回顾近年国内外艾灸法治疗类风湿性关节炎的临床研究文献,梳理艾灸疗法对类风湿性关节炎患者关节肿胀、晨僵、疼痛等症状的改善作用和对生活质量的影响以及实验室指标的变化,提出艾灸在治疗类风湿关节炎临床治疗中的优势,呼吁广大临床工作者及研究者的进一步研究与推广。同时,整理艾灸治疗类风湿关节炎的动物实验研究,从关节组织形态、病理改变、外周炎性细胞因子、中枢神经递质、蛋白组学及艾灸血清的作用等方面呈现艾灸治疗的积极作用。为进一步开展艾灸治疗类风湿关节炎临床研究及探索其作用机制提供思路和参考。
Clinical research literature on rheumatoid arthritis treated by moxibustion was reviewed. The effects of it on syndromes like morning stiffness,joint swelling,pain and quality of life as well as laboratory findings were figured out. The advantages of moxibustion in the treatment of rheumatoid arthritis were put forward and the further research and promotion of clinical workers and researchers were called for. Meanwhile,animal experimental study on moxibustion for treatment of rheumatoid arthritis( RA) were studied,positive affection of moxibustion treatment through changes from joint tissue morphology,pathology,periphery inflammatory cytokines,central nervous system neurotransmitter,proteomics analysis and effect of moxibustion serum were shown. Ideas and references for the further development of clinical research and exploring the mechanism of moxibustion treating rheumatoid arthritis were provied.
Clinical research literature on rheumatoid arthritis treated by moxibustion was reviewed. The effects of it on syndromes like morning stiffness,joint swelling,pain and quality of life as well as laboratory findings were figured out. The advantages of moxibustion in the treatment of rheumatoid arthritis were put forward and the further research and promotion of clinical workers and researchers were called for. Meanwhile,animal experimental study on moxibustion for treatment of rheumatoid arthritis( RA) were studied,positive affection of moxibustion treatment through changes from joint tissue morphology,pathology,periphery inflammatory cytokines,central nervous system neurotransmitter,proteomics analysis and effect of moxibustion serum were shown. Ideas and references for the further development of clinical research and exploring the mechanism of moxibustion treating rheumatoid arthritis were provied.
引文
[1]叶伟胜,张铁良.类风湿关节炎流行病学进展[J].国际骨科学杂志,2009,30(3):144-147.
[2]周莉,黄琴峰,刘健.基于《中医针灸信息库》对针灸治疗类风湿关节炎的临床规律探讨[J].上海针灸杂志,2014,33(11):1059-1063.
[3]何悦硕,梁维超.麦粒灸治疗类风湿性关节炎疗效观察[J].上海针灸杂志,2010,29(7):449-450.
[4]陈开慧,李仁保,李凯,等.艾灸治疗类风湿关节炎的临床效果及其对血IL-6、CRP水平的研究[J].中药药理与临床,2015,31(1):303-304.
[5]郝锋,胡玲,吴子建,等.隔姜灸治疗活动期类风湿关节炎量效关系的临床研究[J].时珍国医国药,2013,24(3):677-680.
[6]胡玲,郝峰,钟峰,等.艾灸治疗类风湿关节炎的多中心随机对照临床研究[J].环球中医药,2011,4(6):401-405.
[7]谢丽琼,谢祖艺,陈丽,等.改良温和悬灸疗法在类风湿关节炎痹症中的应用及护理[J].齐鲁护理杂志,2014,20(11):22-24.
[8]丁放.单纯灸法治疗类风湿关节炎[J].针灸临床杂志,2007,23(10):40-41.
[9]张小芹,窦杰.雷火灸治疗痰瘀痹阻型类风湿关节炎临床观察[J].泰州职业技术学院学报,2015,15(2):64-65.
[10]张泽胜,陈千里.温针灸治疗类风湿性关节炎48例疗效观察[J].新中医,2005,37(7):57-58.
[11]杨熳,吴元建,欧阳八四.温针灸治疗风寒湿阻型类风湿性关节炎35例[J].针灸临床杂志,2010,26(2):29-30.
[12]郭江燕,姜姝姝,高宇晨,等.麦粒灸对佐剂型关节炎大鼠屈关节疼痛实验(缩腿嘶鸣)评分及足容积肿胀度的影响[J].中医药导报,2015,21(11):7-9.
[13]黄迪君,余曙光,韩哲林,等.麦粒灸对实验性RA大鼠局部组织炎症介质的影响[J].上海针灸,2002,21(4):43-44.
[14]黄迪君,韩哲林,罗荣.麦粒灸对实验性RA大鼠足跖肿胀度及滑膜组织Caspase-3表达的影响[J].成都中医药大学学报,2003,26(2):29-30.
[15]罗磊,胡玲,何璐,等.艾灸对类风湿性关节炎大鼠关节滑膜细胞超微结构的影响[J].针刺研究,2011,36(2):105-109.
[16]唐照亮,宋小鸽,章复清,等.艾灸对关节炎大鼠抗炎消肿作用及细胞因子、自由基影响[J].安徽中医学院学报,2001,20(5):34-37.
[17]罗磊,胡玲,宋小鸽,等.艾灸对类风湿关节炎模型大鼠跖关节中细胞因子的影响[J].环球中医药,2011,4(6):416-419.
[18]彭传玉,胡玲.艾灸“肾俞”、“足三里”对类风湿关节炎模型大鼠基质金属蛋白酶-9的影响[J].浙江中医药大学学报,2015,39(1):6-8.
[19]高骏,周海燕,刘旭光,等.艾灸对实验性RA大鼠血浆Th1-Th2细胞因子平衡影响的实验研究[J].成部中医药大学学报,2008,31(1):21-23.
[20]郭江燕.麦粒灸对实验性RA大鼠IL-17-NF-KB通路的影响及抗炎效应机制研究[D].南京:南京中医药大学,2015.
[21]F irestein GS.Invasive fibroblast-like synoviocytes in rheumatoid arthritis.Passive responders or transformed aggressors?[J].Arthritis Rheum,1996,39(11):1781-1790.
[22]彭传玉,胡玲,吴子建,等.艾灸对类风湿关节炎模型大鼠滑膜细胞凋亡的影响[J].云南中医学院学报,2013,36(6):52-55.
[23]魏铮,杨露晨,杨馨,等.艾灸对类风湿性关节炎家兔滑膜细胞Cyclin D1及CDK4蛋白表达的影响[J].中华中医药学刊,2012,30(7):1503-1505.
[24]余曙光,郝亮,宋开源,等.艾灸对类风湿关节炎大鼠血清ICAM-1的影响[J].中国针灸,2002,22(10):690-692.
[25]周峰,胡玲,宋小鸽,等.艾灸对RA大鼠血清及滑膜组织ICAM-1的影响[J].中医药临床杂志,2013,25(4):332-334.
[26]袁娟,胡玲,宋小鸽,等.艾灸对类风湿性关节炎大鼠关节滑膜组织Toll样受体4骨髓样分化因子88核转录因子κB信号通路的影响[J].针刺研究,2015,40(3):199-204.
[27]张传英,邵芙蓉,蔡荣林,等.艾灸对类风湿性关节炎大鼠关节滑膜组织转录信号转导因子1、细胞因子信号负调控因子基因表达的影响[J].针刺研究,2015,40(3):205-209.
[28]张传英,蔡荣林,唐照亮.艾灸对类风湿性关节炎大鼠炎症因子和滑膜细胞凋亡的影响[J].北京中医药大学学报,2014,37(3):190-194.
[29]Peng Chuan-yu,Luo Lei,Hu Ling,et al.Study on the Effect of M oxibustion in Treating Rheumatoid Arthritis Rats and Its Mechanism[J].J Acupunct Tuina Sci,2012,10(6):336-334.
[30]姚剑,胡玲,宋小鸽,等.艾灸“肾俞”“足三里”穴对类风湿关节炎大鼠滑膜组织中Ras-MAPK信号通路的影响[J].世界针灸杂志:英文版,2013,23(2):29-33.
[31]刘旭光,房繄恭,余曙光,等.艾灸对实验性RA家兔关节滑膜液FGF EGF PDGF含量的影响[J].中医药学刊,2006,24(3):428-429.
[32]杨馨,杨慎峭,周海燕,等.艾灸对实验性RA家兔滑膜细胞MAPK信号通路影响的研究[J].中华中医药学刊,2007,25(3):470-474.
[33]杨馨,李继书,杨慎峭,等.艾灸对实验性类风湿性关节炎家兔滑膜细胞JAK-STAT信号通路影响的研究[J].针刺研究,2007,32(2):75-82.
[34]杨馨,刘旭光,王月,等.艾灸对类风湿性关节炎家兔滑膜细胞JAK-STAT通路负反馈调节家族细胞因子信号抑制因子的影响[J].针刺研究,2013,38(2):129-133.
[35]杨慎峭,刘旭光,张平.艾灸对实验性RA家兔关节滑膜液ICAM-1含量影响[J].四川中医,2004,24(11):18-19.
[36]李秀坤,刘旭光,余曙光,等.艾灸对实验性RA家兔滑膜组织PGE2表达的影响[J].中国中医基础医学杂志,2006,12(10):774-776.
[37]余俊辉,刘旭光,余曙光,等.艾灸对实验性类风湿关节炎滑膜细胞原癌基因C-fos和c-myc mRNA表达的影响[J].西部医学,2005,17(2):108-110.
[38]杨慎峭,刘旭光,余曙光,等.艾灸对实验性类风湿性关节炎家兔关节滑膜液MMP-3、TIMP-1含量的影响[J].成都中医药大学学报,2005,28(3):11-12.
[39]刘旭光,杨慎峭,余曙光,等.艾灸对实验性类风湿性关节炎家兔关节滑膜液MMP-3、TIMP-1含量的影响[J].成都中医药大学学报,2005,28(4):1-2.
[40]杨涵棋,刘旭光,杨馨,等.不同灸法对类风湿性关节炎家兔肿胀关节及滑膜液中白介素-1、肿瘤坏死因子-α表达的影响[J].针刺研究,2013,38(28):134-139.
[41]杨馨,黄艺,金荣疆,等.艾灸对基因干扰类风湿性关节炎家兔血清IL-17影响的研究[J].成都中医药大学学报,2014,37(1):24-28.
[42]杨馨,刘旭光,杨涵棋,等.基于慢病毒介导的SOCS1、PIAS1、PTPN22干扰对艾灸调控实验性RA家兔关节滑膜液EGF、FGF水平的影响[J].中华中医药学刊,2015,33(4):816-819.
[43]吴菲,杨涵棋,张耀,等.隔姜灸对RA家兔不同组织HSP70表达的影响[J].中医药学刊,2015,33(4):801-803.
[44]刘旭光,宋开源,郝亮,等.艾灸对实验性RA大鼠热休克蛋白(HSP70)表达的影响[J].中医药学刊,2003,21(7):1034-1051.
[45]刘社兰,张小玉,许德义,等.大鼠海马内5-HT3受体参与神经免疫调制[J].中国免疫学杂志,2002,18(6):414-419.
[46]Jorgensen C.Dysregulation of the hypothalamo-pituitary axis in rheumatoid arthritis[J].J Rheumatol,1995,22(10):1829-1833.
[47]刘杜兰.海马在神经免疫中的作用[J].临床耳鼻咽喉科杂志,1997,11(10):466.
[48]Feldman S,Weidenfeld J.Electrical stimulation of the dorsal hippocampus caused a long lasting inhibition of ACTH and adrenocortical responses to photic stimuli in freely moving rats[J].Brain Res,2001,911(1):22-26.
[49]韩秀引,王蕾,马玉琼,等.LPS对大鼠海马CA2~3区n NOS和FOS蛋白表达的影响[J].四川解剖学杂志,2004,12(1):8-11.
[50]陈晓莉,黄迪君,宋开源,等.麦粒灸对佐剂性关节炎大鼠细胞免疫功能的影响[J].上海针灸杂志,2003,22(1):14-16.
[51]刘旭光,黄迪君,郝亮,等.艾灸对类风湿性关节炎大鼠下丘脑-垂体-肾上腺皮质轴的影响[J].中国中医基础医学杂志,2003,9(2):57-59.
[52]高骏,刘旭光,黄迪君,等.HPAA在艾灸调控类风湿性关节炎大鼠滑膜组织NF-k B信号通路中的作用[J].针刺研究,2009,35(3):198-203.
[53]谢璐霜,唐静,王蕾,等.艾灸对类风湿性关节炎大鼠海马CA1~CA3区及齿状回n NOS表达的影响[J].西部医学,2009,21(5):710-712.
[54]唐照亮,宋小鸽,章复清,等.艾灸治疗类风湿性关节炎抗炎免疫作用机理的研究[J].针刺研究,2003,28(4):292-298.
[55]唐静,谢璐霜,王蕾,等.艾灸对类风湿性关节炎大鼠下丘脑室旁核一氧化氮合酶表达的影响[J].西部医学,2009,21(5):713-715.
[56]刘旭光,周海燕,黄迪君,等.艾灸对实验性RA大鼠海马下丘脑垂体GR表达影响的研究[J].中华中医药学刊,2009,27(9):1797-1799.
[57]周海燕,刘旭光,黄迪君,等.艾灸调整实验性RA大鼠HPAA功能的GR机制研究[J].中华中医药学刊,2010,28(6):1167-1169.
[58]周海燕,刘旭光,高骏.艾灸对实验性类风湿性关节炎大鼠海马GR、MEL1B表达影响的研究[J].辽宁中医杂志,2012,39(11):2313-2315.
[59]郑保主,胡玲,宋小鸽,等.艾灸对类风湿关节炎大鼠下丘脑POMCmRNA和PDYNmRNA表达的影响[J].中国针灸,2013,33(5):433-437.
[60]吴菲,杨涵棋,张耀,等.隔姜灸对RA家兔不同组织HSP70表达的影响[J].中华中医药学刊,2015,33(4):801-803.
[61]Zheng X,Wu SL,Hincapie M,et al.Study of the human plasma proteome of rheumatoid arthritis[J].J Chromatogr A,2009,1216(16):3538-3545.
[62]Jin EH,Shim SC,Kim HG,et al.Polymorphisms of COTL1gene identified by proteomic approach and their association with autoimmune disorders[J].Exp Mol Med,2009,41(5):354-361.
[63]Dasuri K,Antonovici M,Chen K,et al.The synovial proteome:analysis of fibroblast-like synoviocytes[J].Arthritis Res Ther,2004,6(2):R161-R168.
[64]Dotzlaw H,Schulz M,Eggert M,et al.A pattern of protein expression in peripheral blood mononuclear cells distinguishes rheumatoid arthritis patients from healthy individuals[J].Biochim Biophys Acta,2004,1696(1):121-129.
[65]Schulz M,Dotzlaw H,Mikkat S,et al.Proteomic analysis of peripheral blood mononuclear cells:selective protein processing observed in patients with rheumatoid arthritis[J].J Proteome Res,2007 Sep,6(9):3752-3759.
[66]Giusti L,Baldini C,Ciregia F,et al.Is GRP78/Bi P a potential salivary biomarker in patients with rheumatoid arthritis[J].Proteomics Clin Appl,2010,4(3):315-324.
[67]Park YJ,Chung MK,Hwang D,et al.Proteomics in Rheumatoid Arthritis Research[J].Immune Netw,2015,15(4):177-185.
[68]江星,孙志岭,周丹萍,等.艾灸对类风湿关节炎模型大鼠滑膜病变的影响[J].中国老年学杂志,2015,35(19):5386-5389.
[69]Xiao Xu,Miao-Miao Wang,Zhi ling Sun,et al.Discovery of serum proteomic biomarkers for prediction of response to moxibustion treatment rats with collagen inducedarthritis:an exploratory analysis[J].Acupunct Med,2016,34(3):184-193.
[70]陈汉平,裴建.关于“针灸血清”方法的研究和应用[J].上海针灸杂志,1998,1(17):1-2.
[71]孙德利,陈汉平.“针灸血清”的研究方法及意义[J].浙江中医学院学报,1999,23(3):59.
[72]杨露晨,魏铮,吴巧凤,等.艾灸血清对实验性RA滑膜细胞增殖及细胞周期的影响[J].成都中医药大学学报,2008,31(2):33-35.
[73]刘鳐,张付平,王蕾,等.不同灸法艾灸血清对类风湿关节炎滑膜成纤维细胞的影响[J].西部医学,2015,27(10):1445-1448.
[74]Niimoto T,Nakasa T,Ishikawa M,et al.MicroRNA-146a expresses in interleukin-17 producing T cells in rheumatoid arthritis patientss[J].BMC Musculoskelet Disord,2010,11:209.
[75]Chen Y,Xian PF,Yang L,et al.MicroRNA-21 Promotes Proliferation of Fibroblast-Like Synoviocytes through Mediation of NF-κB Nuclear Translocation in a Rat Model of CollagenInduced Rheumatoid Arthritis[J].Biomed Res Int,2016,2016:9279078.
[76]Elmesmari A,Fraser AR,Wood C,et al.MicroRNA-155regulates monocyte chemokine and chemokine receptor expression in Rheumatoid Arthritis[M].Rheumatology(Oxford),2016:kew272.
[2]周莉,黄琴峰,刘健.基于《中医针灸信息库》对针灸治疗类风湿关节炎的临床规律探讨[J].上海针灸杂志,2014,33(11):1059-1063.
[3]何悦硕,梁维超.麦粒灸治疗类风湿性关节炎疗效观察[J].上海针灸杂志,2010,29(7):449-450.
[4]陈开慧,李仁保,李凯,等.艾灸治疗类风湿关节炎的临床效果及其对血IL-6、CRP水平的研究[J].中药药理与临床,2015,31(1):303-304.
[5]郝锋,胡玲,吴子建,等.隔姜灸治疗活动期类风湿关节炎量效关系的临床研究[J].时珍国医国药,2013,24(3):677-680.
[6]胡玲,郝峰,钟峰,等.艾灸治疗类风湿关节炎的多中心随机对照临床研究[J].环球中医药,2011,4(6):401-405.
[7]谢丽琼,谢祖艺,陈丽,等.改良温和悬灸疗法在类风湿关节炎痹症中的应用及护理[J].齐鲁护理杂志,2014,20(11):22-24.
[8]丁放.单纯灸法治疗类风湿关节炎[J].针灸临床杂志,2007,23(10):40-41.
[9]张小芹,窦杰.雷火灸治疗痰瘀痹阻型类风湿关节炎临床观察[J].泰州职业技术学院学报,2015,15(2):64-65.
[10]张泽胜,陈千里.温针灸治疗类风湿性关节炎48例疗效观察[J].新中医,2005,37(7):57-58.
[11]杨熳,吴元建,欧阳八四.温针灸治疗风寒湿阻型类风湿性关节炎35例[J].针灸临床杂志,2010,26(2):29-30.
[12]郭江燕,姜姝姝,高宇晨,等.麦粒灸对佐剂型关节炎大鼠屈关节疼痛实验(缩腿嘶鸣)评分及足容积肿胀度的影响[J].中医药导报,2015,21(11):7-9.
[13]黄迪君,余曙光,韩哲林,等.麦粒灸对实验性RA大鼠局部组织炎症介质的影响[J].上海针灸,2002,21(4):43-44.
[14]黄迪君,韩哲林,罗荣.麦粒灸对实验性RA大鼠足跖肿胀度及滑膜组织Caspase-3表达的影响[J].成都中医药大学学报,2003,26(2):29-30.
[15]罗磊,胡玲,何璐,等.艾灸对类风湿性关节炎大鼠关节滑膜细胞超微结构的影响[J].针刺研究,2011,36(2):105-109.
[16]唐照亮,宋小鸽,章复清,等.艾灸对关节炎大鼠抗炎消肿作用及细胞因子、自由基影响[J].安徽中医学院学报,2001,20(5):34-37.
[17]罗磊,胡玲,宋小鸽,等.艾灸对类风湿关节炎模型大鼠跖关节中细胞因子的影响[J].环球中医药,2011,4(6):416-419.
[18]彭传玉,胡玲.艾灸“肾俞”、“足三里”对类风湿关节炎模型大鼠基质金属蛋白酶-9的影响[J].浙江中医药大学学报,2015,39(1):6-8.
[19]高骏,周海燕,刘旭光,等.艾灸对实验性RA大鼠血浆Th1-Th2细胞因子平衡影响的实验研究[J].成部中医药大学学报,2008,31(1):21-23.
[20]郭江燕.麦粒灸对实验性RA大鼠IL-17-NF-KB通路的影响及抗炎效应机制研究[D].南京:南京中医药大学,2015.
[21]F irestein GS.Invasive fibroblast-like synoviocytes in rheumatoid arthritis.Passive responders or transformed aggressors?[J].Arthritis Rheum,1996,39(11):1781-1790.
[22]彭传玉,胡玲,吴子建,等.艾灸对类风湿关节炎模型大鼠滑膜细胞凋亡的影响[J].云南中医学院学报,2013,36(6):52-55.
[23]魏铮,杨露晨,杨馨,等.艾灸对类风湿性关节炎家兔滑膜细胞Cyclin D1及CDK4蛋白表达的影响[J].中华中医药学刊,2012,30(7):1503-1505.
[24]余曙光,郝亮,宋开源,等.艾灸对类风湿关节炎大鼠血清ICAM-1的影响[J].中国针灸,2002,22(10):690-692.
[25]周峰,胡玲,宋小鸽,等.艾灸对RA大鼠血清及滑膜组织ICAM-1的影响[J].中医药临床杂志,2013,25(4):332-334.
[26]袁娟,胡玲,宋小鸽,等.艾灸对类风湿性关节炎大鼠关节滑膜组织Toll样受体4骨髓样分化因子88核转录因子κB信号通路的影响[J].针刺研究,2015,40(3):199-204.
[27]张传英,邵芙蓉,蔡荣林,等.艾灸对类风湿性关节炎大鼠关节滑膜组织转录信号转导因子1、细胞因子信号负调控因子基因表达的影响[J].针刺研究,2015,40(3):205-209.
[28]张传英,蔡荣林,唐照亮.艾灸对类风湿性关节炎大鼠炎症因子和滑膜细胞凋亡的影响[J].北京中医药大学学报,2014,37(3):190-194.
[29]Peng Chuan-yu,Luo Lei,Hu Ling,et al.Study on the Effect of M oxibustion in Treating Rheumatoid Arthritis Rats and Its Mechanism[J].J Acupunct Tuina Sci,2012,10(6):336-334.
[30]姚剑,胡玲,宋小鸽,等.艾灸“肾俞”“足三里”穴对类风湿关节炎大鼠滑膜组织中Ras-MAPK信号通路的影响[J].世界针灸杂志:英文版,2013,23(2):29-33.
[31]刘旭光,房繄恭,余曙光,等.艾灸对实验性RA家兔关节滑膜液FGF EGF PDGF含量的影响[J].中医药学刊,2006,24(3):428-429.
[32]杨馨,杨慎峭,周海燕,等.艾灸对实验性RA家兔滑膜细胞MAPK信号通路影响的研究[J].中华中医药学刊,2007,25(3):470-474.
[33]杨馨,李继书,杨慎峭,等.艾灸对实验性类风湿性关节炎家兔滑膜细胞JAK-STAT信号通路影响的研究[J].针刺研究,2007,32(2):75-82.
[34]杨馨,刘旭光,王月,等.艾灸对类风湿性关节炎家兔滑膜细胞JAK-STAT通路负反馈调节家族细胞因子信号抑制因子的影响[J].针刺研究,2013,38(2):129-133.
[35]杨慎峭,刘旭光,张平.艾灸对实验性RA家兔关节滑膜液ICAM-1含量影响[J].四川中医,2004,24(11):18-19.
[36]李秀坤,刘旭光,余曙光,等.艾灸对实验性RA家兔滑膜组织PGE2表达的影响[J].中国中医基础医学杂志,2006,12(10):774-776.
[37]余俊辉,刘旭光,余曙光,等.艾灸对实验性类风湿关节炎滑膜细胞原癌基因C-fos和c-myc mRNA表达的影响[J].西部医学,2005,17(2):108-110.
[38]杨慎峭,刘旭光,余曙光,等.艾灸对实验性类风湿性关节炎家兔关节滑膜液MMP-3、TIMP-1含量的影响[J].成都中医药大学学报,2005,28(3):11-12.
[39]刘旭光,杨慎峭,余曙光,等.艾灸对实验性类风湿性关节炎家兔关节滑膜液MMP-3、TIMP-1含量的影响[J].成都中医药大学学报,2005,28(4):1-2.
[40]杨涵棋,刘旭光,杨馨,等.不同灸法对类风湿性关节炎家兔肿胀关节及滑膜液中白介素-1、肿瘤坏死因子-α表达的影响[J].针刺研究,2013,38(28):134-139.
[41]杨馨,黄艺,金荣疆,等.艾灸对基因干扰类风湿性关节炎家兔血清IL-17影响的研究[J].成都中医药大学学报,2014,37(1):24-28.
[42]杨馨,刘旭光,杨涵棋,等.基于慢病毒介导的SOCS1、PIAS1、PTPN22干扰对艾灸调控实验性RA家兔关节滑膜液EGF、FGF水平的影响[J].中华中医药学刊,2015,33(4):816-819.
[43]吴菲,杨涵棋,张耀,等.隔姜灸对RA家兔不同组织HSP70表达的影响[J].中医药学刊,2015,33(4):801-803.
[44]刘旭光,宋开源,郝亮,等.艾灸对实验性RA大鼠热休克蛋白(HSP70)表达的影响[J].中医药学刊,2003,21(7):1034-1051.
[45]刘社兰,张小玉,许德义,等.大鼠海马内5-HT3受体参与神经免疫调制[J].中国免疫学杂志,2002,18(6):414-419.
[46]Jorgensen C.Dysregulation of the hypothalamo-pituitary axis in rheumatoid arthritis[J].J Rheumatol,1995,22(10):1829-1833.
[47]刘杜兰.海马在神经免疫中的作用[J].临床耳鼻咽喉科杂志,1997,11(10):466.
[48]Feldman S,Weidenfeld J.Electrical stimulation of the dorsal hippocampus caused a long lasting inhibition of ACTH and adrenocortical responses to photic stimuli in freely moving rats[J].Brain Res,2001,911(1):22-26.
[49]韩秀引,王蕾,马玉琼,等.LPS对大鼠海马CA2~3区n NOS和FOS蛋白表达的影响[J].四川解剖学杂志,2004,12(1):8-11.
[50]陈晓莉,黄迪君,宋开源,等.麦粒灸对佐剂性关节炎大鼠细胞免疫功能的影响[J].上海针灸杂志,2003,22(1):14-16.
[51]刘旭光,黄迪君,郝亮,等.艾灸对类风湿性关节炎大鼠下丘脑-垂体-肾上腺皮质轴的影响[J].中国中医基础医学杂志,2003,9(2):57-59.
[52]高骏,刘旭光,黄迪君,等.HPAA在艾灸调控类风湿性关节炎大鼠滑膜组织NF-k B信号通路中的作用[J].针刺研究,2009,35(3):198-203.
[53]谢璐霜,唐静,王蕾,等.艾灸对类风湿性关节炎大鼠海马CA1~CA3区及齿状回n NOS表达的影响[J].西部医学,2009,21(5):710-712.
[54]唐照亮,宋小鸽,章复清,等.艾灸治疗类风湿性关节炎抗炎免疫作用机理的研究[J].针刺研究,2003,28(4):292-298.
[55]唐静,谢璐霜,王蕾,等.艾灸对类风湿性关节炎大鼠下丘脑室旁核一氧化氮合酶表达的影响[J].西部医学,2009,21(5):713-715.
[56]刘旭光,周海燕,黄迪君,等.艾灸对实验性RA大鼠海马下丘脑垂体GR表达影响的研究[J].中华中医药学刊,2009,27(9):1797-1799.
[57]周海燕,刘旭光,黄迪君,等.艾灸调整实验性RA大鼠HPAA功能的GR机制研究[J].中华中医药学刊,2010,28(6):1167-1169.
[58]周海燕,刘旭光,高骏.艾灸对实验性类风湿性关节炎大鼠海马GR、MEL1B表达影响的研究[J].辽宁中医杂志,2012,39(11):2313-2315.
[59]郑保主,胡玲,宋小鸽,等.艾灸对类风湿关节炎大鼠下丘脑POMCmRNA和PDYNmRNA表达的影响[J].中国针灸,2013,33(5):433-437.
[60]吴菲,杨涵棋,张耀,等.隔姜灸对RA家兔不同组织HSP70表达的影响[J].中华中医药学刊,2015,33(4):801-803.
[61]Zheng X,Wu SL,Hincapie M,et al.Study of the human plasma proteome of rheumatoid arthritis[J].J Chromatogr A,2009,1216(16):3538-3545.
[62]Jin EH,Shim SC,Kim HG,et al.Polymorphisms of COTL1gene identified by proteomic approach and their association with autoimmune disorders[J].Exp Mol Med,2009,41(5):354-361.
[63]Dasuri K,Antonovici M,Chen K,et al.The synovial proteome:analysis of fibroblast-like synoviocytes[J].Arthritis Res Ther,2004,6(2):R161-R168.
[64]Dotzlaw H,Schulz M,Eggert M,et al.A pattern of protein expression in peripheral blood mononuclear cells distinguishes rheumatoid arthritis patients from healthy individuals[J].Biochim Biophys Acta,2004,1696(1):121-129.
[65]Schulz M,Dotzlaw H,Mikkat S,et al.Proteomic analysis of peripheral blood mononuclear cells:selective protein processing observed in patients with rheumatoid arthritis[J].J Proteome Res,2007 Sep,6(9):3752-3759.
[66]Giusti L,Baldini C,Ciregia F,et al.Is GRP78/Bi P a potential salivary biomarker in patients with rheumatoid arthritis[J].Proteomics Clin Appl,2010,4(3):315-324.
[67]Park YJ,Chung MK,Hwang D,et al.Proteomics in Rheumatoid Arthritis Research[J].Immune Netw,2015,15(4):177-185.
[68]江星,孙志岭,周丹萍,等.艾灸对类风湿关节炎模型大鼠滑膜病变的影响[J].中国老年学杂志,2015,35(19):5386-5389.
[69]Xiao Xu,Miao-Miao Wang,Zhi ling Sun,et al.Discovery of serum proteomic biomarkers for prediction of response to moxibustion treatment rats with collagen inducedarthritis:an exploratory analysis[J].Acupunct Med,2016,34(3):184-193.
[70]陈汉平,裴建.关于“针灸血清”方法的研究和应用[J].上海针灸杂志,1998,1(17):1-2.
[71]孙德利,陈汉平.“针灸血清”的研究方法及意义[J].浙江中医学院学报,1999,23(3):59.
[72]杨露晨,魏铮,吴巧凤,等.艾灸血清对实验性RA滑膜细胞增殖及细胞周期的影响[J].成都中医药大学学报,2008,31(2):33-35.
[73]刘鳐,张付平,王蕾,等.不同灸法艾灸血清对类风湿关节炎滑膜成纤维细胞的影响[J].西部医学,2015,27(10):1445-1448.
[74]Niimoto T,Nakasa T,Ishikawa M,et al.MicroRNA-146a expresses in interleukin-17 producing T cells in rheumatoid arthritis patientss[J].BMC Musculoskelet Disord,2010,11:209.
[75]Chen Y,Xian PF,Yang L,et al.MicroRNA-21 Promotes Proliferation of Fibroblast-Like Synoviocytes through Mediation of NF-κB Nuclear Translocation in a Rat Model of CollagenInduced Rheumatoid Arthritis[J].Biomed Res Int,2016,2016:9279078.
[76]Elmesmari A,Fraser AR,Wood C,et al.MicroRNA-155regulates monocyte chemokine and chemokine receptor expression in Rheumatoid Arthritis[M].Rheumatology(Oxford),2016:kew272.