麦粒灸对佐剂型关节炎大鼠屈关节疼痛实验(缩腿嘶鸣)评分及足容积肿胀度的影响
|
摘要
目的:观察麦粒灸对实验性类风湿关节炎(RA)大鼠屈关节疼痛实验评分和足趾肿胀度的影响。方法:以佐剂性关节炎作为类风湿关节炎大鼠模型,除空白组外,均用弗氏完全佐剂造模,麦粒灸RA大鼠"肾俞"、"足三里",记录屈关节疼痛实验评分,测量大鼠后足肿胀程度。结果:造模后屈关节疼痛实验评分及足趾肿胀度明显上升,麦粒灸治疗后屈关节疼痛实验评分及足趾肿胀度均降低。结论:麦粒灸可以降低屈关节疼痛实验评分及减轻佐剂关节炎大鼠的足趾肿胀度,提示麦粒灸对实验性RA大鼠有一定的治疗作用。
Objective: To investigate effects of grain-moxibustion on Arthritic flexion pain test and paw swelling in Rats with adjuvant arthritis. Methods: Adjuvant Arthritis(AA) was used as experiment arthritis model to fulfill each of the arthritis group. Treatment for AA rats is the grain-moxibustion on selected acupoints "Shenshu(BL23)" and "Zusanli(ST36)".In the pro-cess of the experiment, the score of the Arthritic flexion pain test and the volume of the swollen paw have been recorded re-spectively. Results: The increase of the score of the Arthritic flexion pain test and the volume of the swollen paw had observed after the establishment of AA model, however, when the grain-moxibustion therapy has done; the achievements are the decrease of the both two standards Conclusion: The dropped score of the Arthritic flexion pain test and the ameliorated volume of swollen paw both implying grain-moxibustion is an effective treatment for AA experiment rats.
Objective: To investigate effects of grain-moxibustion on Arthritic flexion pain test and paw swelling in Rats with adjuvant arthritis. Methods: Adjuvant Arthritis(AA) was used as experiment arthritis model to fulfill each of the arthritis group. Treatment for AA rats is the grain-moxibustion on selected acupoints "Shenshu(BL23)" and "Zusanli(ST36)".In the pro-cess of the experiment, the score of the Arthritic flexion pain test and the volume of the swollen paw have been recorded re-spectively. Results: The increase of the score of the Arthritic flexion pain test and the volume of the swollen paw had observed after the establishment of AA model, however, when the grain-moxibustion therapy has done; the achievements are the decrease of the both two standards Conclusion: The dropped score of the Arthritic flexion pain test and the ameliorated volume of swollen paw both implying grain-moxibustion is an effective treatment for AA experiment rats.
引文
[1]叶伟盛,张铁良.类风湿关节炎流行病学进展[J].国际骨科学杂志,2009,30(3):144-147.
[2]李建武,曾超.艾灸治疗类风湿关节炎概况[J].湖北中医药杂志,2012,34(6):63-64.
[3]蔡玉梅,郑继范,黄文燕.麦粒灸的临床应用和实验研究进展[J].针灸临床杂志,2008,24(9):61-62.
[4]刘红香,熊亮,韩济生,等.大鼠踝关节疼痛试验评分指标的改进[J].中国疼痛医学杂志,1998,4(3):173-178.
[5]彭传玉,罗磊,胡玲,等.不同剂量弗氏完全佐剂对类风湿关节炎模型大鼠复制的影响[J].中国医药指南,2012,10(1):1-3.
[6]中国畜牧兽医学会.中国兽医针灸学[M].北京:农业出版社,1984:213.
[7]La Belle A,Tislow R.A method of evaluating analgesics of the anti-arthralgic type in the laboratory animal[J].J Pharmacol Exp Ther,1950,98:19.
[8]Calvino B,Crepon-Bernard M,Le Bars D.Parallel clinical and behavioural studies of adjuvant-induced arthritis in the rat:possible relationship with'chronic pain[J].Behav Brain Res,1987,24:11-19.
[9]Braga PC,Dalsasso M,Bemini A,et al.Antinociceptive activity of salmon calci-tonin-electrophysiological correlates in a rat chronic pain model[J].Neurosci Lett,1993,151:85-88.
[10]Calvino B,Couraud JY,Besson JM.Prevaccination with diluted Freund adjuvant prevents the development of chronic pain and transient release of cerebrospinal fluid substance P in adjuvant-induced arthritis in rats Pain[J].Journal of Allergy and Clinical Immunology,1994,58:211-217.
[11]刘红香,许伟,罗非,等.改进的大鼠单发佐剂性关节炎模型的建立和实验观察[J].中国疼痛医学杂志,1996(2):223-118.
[12]王新丽,左帮平,刘旭光.艾灸治疗类风湿关节炎的作用机制研究进展[J].中华中医药学刊,2013,31(9):1888-1890
[2]李建武,曾超.艾灸治疗类风湿关节炎概况[J].湖北中医药杂志,2012,34(6):63-64.
[3]蔡玉梅,郑继范,黄文燕.麦粒灸的临床应用和实验研究进展[J].针灸临床杂志,2008,24(9):61-62.
[4]刘红香,熊亮,韩济生,等.大鼠踝关节疼痛试验评分指标的改进[J].中国疼痛医学杂志,1998,4(3):173-178.
[5]彭传玉,罗磊,胡玲,等.不同剂量弗氏完全佐剂对类风湿关节炎模型大鼠复制的影响[J].中国医药指南,2012,10(1):1-3.
[6]中国畜牧兽医学会.中国兽医针灸学[M].北京:农业出版社,1984:213.
[7]La Belle A,Tislow R.A method of evaluating analgesics of the anti-arthralgic type in the laboratory animal[J].J Pharmacol Exp Ther,1950,98:19.
[8]Calvino B,Crepon-Bernard M,Le Bars D.Parallel clinical and behavioural studies of adjuvant-induced arthritis in the rat:possible relationship with'chronic pain[J].Behav Brain Res,1987,24:11-19.
[9]Braga PC,Dalsasso M,Bemini A,et al.Antinociceptive activity of salmon calci-tonin-electrophysiological correlates in a rat chronic pain model[J].Neurosci Lett,1993,151:85-88.
[10]Calvino B,Couraud JY,Besson JM.Prevaccination with diluted Freund adjuvant prevents the development of chronic pain and transient release of cerebrospinal fluid substance P in adjuvant-induced arthritis in rats Pain[J].Journal of Allergy and Clinical Immunology,1994,58:211-217.
[11]刘红香,许伟,罗非,等.改进的大鼠单发佐剂性关节炎模型的建立和实验观察[J].中国疼痛医学杂志,1996(2):223-118.
[12]王新丽,左帮平,刘旭光.艾灸治疗类风湿关节炎的作用机制研究进展[J].中华中医药学刊,2013,31(9):1888-1890