应用发射CT对行为失常儿童脑部易损靶点及影像特征的可视化研究
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摘要
目的:为了提高行为失常患儿早期诊断的准确性,利于进行早期干预性治疗,我们利用功能影像技术SPECT成像对行为失常儿童可能存在的脑损伤靶点进行了探讨和分析。方法:回顾性研究了304例已确诊的行为失常儿童SPECT影像和临床资料,并对SPECT影像结果分别进行可视化靶点对应分析和定量统计学分析。结果:102例Autism患儿损伤靶点部位为颞叶+额前皮质(79.4%);43例ASPERGERS征损伤靶点部位为颞叶+枕叶视皮质区(74.4%);93例ADHD损伤靶点部位为基底神经节区(96.7%);66例Tic损伤靶点部位为额叶-颞叶-基底神经节形成环状结构(90.9%)。结论:行为失常患儿SPECT影像结果显示确实存在脑内易损靶点部位,借助于分析和关注这些脑内对应靶点影像特征,有助于对这些疾病的早期诊断及避免误诊漏诊,进而有利于早期干预和治疗。
Object: In order to improve the accuracy of early diagnosis of children with behavioral disorders,which is conducive to early intervention treatment,we explored and analyzed the potential injury targets in brain in children with behavioral disorders by using functional imaging techniques SPECT imaging. Methods: SPECT images and clinical data of304 children with clinically diagnosed behavioral disorders were retrospectively studied,and SPECT images were analyzed visually and quantitatively. Results: The injury targets in brain of 102 Autism were temporal lobe and frontal cortex(79. 4%),43 ASPERGERS were temporal lobe and occipital lobe visual cortex area(74. 4%),93 ADHD were basal ganglia(96. 7%),66 Tic were frontal cortex-temporal lobe-basal ganglia cyclic( 90. 9%). Conclusion: SPECT images showed that there were indeed vulnerable injury targets in the brain of children with behavioral disorders,and it is helpful for early diagnosis and avoiding misdiagnosis or missed diagnosis by analyzing the SPECT images of the vulnerable injury targets,which is beneficial to the early intervention and treatment.
Object: In order to improve the accuracy of early diagnosis of children with behavioral disorders,which is conducive to early intervention treatment,we explored and analyzed the potential injury targets in brain in children with behavioral disorders by using functional imaging techniques SPECT imaging. Methods: SPECT images and clinical data of304 children with clinically diagnosed behavioral disorders were retrospectively studied,and SPECT images were analyzed visually and quantitatively. Results: The injury targets in brain of 102 Autism were temporal lobe and frontal cortex(79. 4%),43 ASPERGERS were temporal lobe and occipital lobe visual cortex area(74. 4%),93 ADHD were basal ganglia(96. 7%),66 Tic were frontal cortex-temporal lobe-basal ganglia cyclic( 90. 9%). Conclusion: SPECT images showed that there were indeed vulnerable injury targets in the brain of children with behavioral disorders,and it is helpful for early diagnosis and avoiding misdiagnosis or missed diagnosis by analyzing the SPECT images of the vulnerable injury targets,which is beneficial to the early intervention and treatment.
引文
1 Nazari M A,Berquin P,Missonnier P,et al.Visual sensory processing deficit in the occipital region in children with attention-deficit/hyperactivity disorder as revealed by eventrelated potentials during cued continuous performance test.Neurophysiol Clin.2010,40(3):137-149.
2 Goepel J,Kissler J,Rockstroh B,et al.Medio-frontal and anterior temporal abnormalities in children with attention deficit hyperactivity disorder(ADHD)during an acoustic antisaccade task as revealed by electro-cortical source reconstruction.BMC Psychiatry.2011,11(3):7-14.
3 Lorberboym M,Watemberg N,Nissenkorn A,et al.Technetium 99m ethylcysteinate dimer single-photon emission computed tomography(SPECT)during intellectual stress test in children and adolescents with pure versus comorbid attention deficit htperactivity disorder.J Child Neurol.2004,19(2):91-96.
4 Virginia C N wong,MBBS(HK),MRCP(UK),et al.Pilot study of Positron Emission Tomography(PET)Brain Glucose Metabolism to Assess the Efficacy of Tongue and Body Acupuncture in Cerebral Palsy.Journal of Child Neurology,2006,21(6):455-464.
5 贾少微,孙涛涛,樊蓉等.针刺治疗儿童孤独症单光子发射计算机断层成像术可视化研究。中国中西医结合杂志,2008,28(10):886-889.
6 中华医学会精神科分会.CCMD-3中国精神障碍分类与诊断标准.第3版.济南:山东科学技术出版社,2001:147-149.
7 高宙,胡疏,陈清等。多动症伴学习困难患儿SPECT显像特点及临床应用。中国医学影像技术杂志,2008,24(S):197-199.
8 张嘉辉,杨红杰,贾少微等。应用SPECT评价HANS数码针刺治疗ADHD的疗效[J]。中国疼痛医学杂志,2014,20(6):416-420.
2 Goepel J,Kissler J,Rockstroh B,et al.Medio-frontal and anterior temporal abnormalities in children with attention deficit hyperactivity disorder(ADHD)during an acoustic antisaccade task as revealed by electro-cortical source reconstruction.BMC Psychiatry.2011,11(3):7-14.
3 Lorberboym M,Watemberg N,Nissenkorn A,et al.Technetium 99m ethylcysteinate dimer single-photon emission computed tomography(SPECT)during intellectual stress test in children and adolescents with pure versus comorbid attention deficit htperactivity disorder.J Child Neurol.2004,19(2):91-96.
4 Virginia C N wong,MBBS(HK),MRCP(UK),et al.Pilot study of Positron Emission Tomography(PET)Brain Glucose Metabolism to Assess the Efficacy of Tongue and Body Acupuncture in Cerebral Palsy.Journal of Child Neurology,2006,21(6):455-464.
5 贾少微,孙涛涛,樊蓉等.针刺治疗儿童孤独症单光子发射计算机断层成像术可视化研究。中国中西医结合杂志,2008,28(10):886-889.
6 中华医学会精神科分会.CCMD-3中国精神障碍分类与诊断标准.第3版.济南:山东科学技术出版社,2001:147-149.
7 高宙,胡疏,陈清等。多动症伴学习困难患儿SPECT显像特点及临床应用。中国医学影像技术杂志,2008,24(S):197-199.
8 张嘉辉,杨红杰,贾少微等。应用SPECT评价HANS数码针刺治疗ADHD的疗效[J]。中国疼痛医学杂志,2014,20(6):416-420.