右美托咪定对ICU颅脑损伤术后机械通气患者血流动力学及胃肠功能恢复的影响
摘要
<正>机械通气是ICU危重病救治中呼吸支持的主要手段,进行机械通气时,患者通常有一定的人机对抗从而使氧耗增加、意外拔除导管和各种装置及导管相关性感染发生率增加,对患者产生有害影响,甚至危及生命安全,因此,镇静与镇痛是保护危重患者安全的重要手段。目前最常用的镇静药物是苯二氮卓类和丙泊酚,但这两种药物容易引起呼吸抑制和血流动力学不稳定,右美托咪定是目前唯一兼具有良好镇静与镇痛作用的药物,可以产
引文
[1]郝江,罗积慎,翁奇,等.右美托咪定与异丙酚对颅脑创伤患者β-内啡肽水平的影响及镇静疗效对比研究[J].中华危重病急救医学,2013,25(6):373-376.
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[7]罗红敏.右美托咪定对需机械通气的脓毒症患者病死率及无机械通气天数的影响:一项随机对照试验[J].中华危重病急救医学,2017,29(7):632.
[8]郑蓓蓓,王迪芬,付江泉,等.右美托咪定与咪达唑仑在机械通气重症患者镇静治疗中的比较研究[J].中国中西医结合急救杂志,2015,22(3):307-311.
[2]YOKOTA H.Post-operative dexmedetomidine-based sedation after uneventful intracranial surgery for unruptured cerebral aneurysm:comparison with propofol-based sedation[J].Neurocrit Care,2011,14(2):182-187.
[3]SASSI M.Safety in the use of dexmedetomidine(precedex)for deep brain stimulation surgery:our experience in23 randomized patients[J].Neuromodulation,2013,16(5):401-406.
[4]朱明,李艳.右美托咪定与地西泮用于ICU重型颅脑外伤患者镇静效果比较研究[J].医学综述,2014,20(3):568-569,574.
[5]TANG J F,CHEN P L,TANG E J.Dexmedetomidine controls agitation and facilitates reliable,serial neurological examinations in a non-intubated patient with traumatic brain injury[J].Neurocrit Care,2011,15(1):175-181.
[6]DU X,YU J.The effect of dexmedetomidine on the perioperative hemodynamics and postoperative cognitive function of elderly patients with hypertension:Study protocol for a randomized controlled trial[J].Medicine(Baltimore),2018,97:e12851.
[7]罗红敏.右美托咪定对需机械通气的脓毒症患者病死率及无机械通气天数的影响:一项随机对照试验[J].中华危重病急救医学,2017,29(7):632.
[8]郑蓓蓓,王迪芬,付江泉,等.右美托咪定与咪达唑仑在机械通气重症患者镇静治疗中的比较研究[J].中国中西医结合急救杂志,2015,22(3):307-311.