黄河三角洲地区妊娠期女性血清维生素A、D水平的分析
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摘要
目的分析黄河三角洲地区妊娠期女性的血清维生素A、D水平。方法选取2017年9月～2018年9月就诊于滨州医学院附属医院产科的755例妊娠期女性作为研究对象,采用天津兰标电化学法维生素检测仪LK3000V检测妊娠期女性血清中的维生素A、D水平。结果不同年龄孕妇的血清维生素A、D水平比较,差异无统计学意义(P>0.05)。30～35岁孕妇的血清维生素A异常率高于<30岁和>35岁孕妇,<30岁孕妇的血清维生素D异常率高于>35岁孕妇,但差异无统计学意义(P>0.05)。妊娠早、中期孕妇血清维生素A水平低于妊娠晚期,差异有统计学意义(P<0.05);妊娠早、中期孕妇的血清维生素D水平高于妊娠晚期,差异有统计学意义(P<0.05)。春季、夏季和秋季孕妇的血清维生素D水平高于冬季,差异有统计学意义(P<0.05);春季孕妇的血清维生素D水平高于秋季,差异有统计学意义(P<0.05)。冬季的血清维生素D异常率高于春季、夏季、秋季,差异有统计学意义(P<0.05)。结论对孕妇体内维生素A、D水平进行分析可为临床对妊娠期女性进行预防性补充维生素A、D提供参考。
Objective To analyze the serum vitamin A and vitamin D level in pregnant women in the Yellow River Delta. Methods All of 755 pregnant women treated in obstetrics department of Affiliated Hospital of Binzhou Medical University from September 2017 to September 2018 were selected as study subjects. The levels of serum vitamin A and vitamin D in pregnant women were detected by Tianjin Lanbiao electrochemical vitamin detector LK3000 V. Results There were no significant difference in serum vitamin A and D levels among pregnant women of different age groups(P>0.05). The abnormal rate of serum vitamin A in pregnant women aged 30-35 was higher than that in pregnant women aged <30 and >35, and the abnormal rate of serum vitamin D in pregnant women aged <30 was higher than that in pregnant women aged >35, but there were no significant differences(P>0.05). The serum vitamin A level of early and mid-pregnancy women was lower than that of late pregnancy, and the differences were statistically significant(P<0.05),the serum vitamin D level of early and mid-pregnancy women was higher than that of late pregnancy, and the differences were statistically significant(P<0.05). The serum vitamin D level of pregnant women in spring, summer and autumn was higher than that in winter(P<0.05), and the differences were statistically significant(P<0.05); the serum vitamin D level of pregnant women in spring was higher than that in autumn, and the differences were statistically significant(P<0.05). The abnormal rate of serum vitamin D in winter was higher than that in spring, summer and autumn, and the differences were statistically significant(P <0.05). Conclusion The analysis of vitamin A and D levels in pregnant women can provide a reference for the clinical prophylactic supplementation of vitamin A and D in pregnant women.
Objective To analyze the serum vitamin A and vitamin D level in pregnant women in the Yellow River Delta. Methods All of 755 pregnant women treated in obstetrics department of Affiliated Hospital of Binzhou Medical University from September 2017 to September 2018 were selected as study subjects. The levels of serum vitamin A and vitamin D in pregnant women were detected by Tianjin Lanbiao electrochemical vitamin detector LK3000 V. Results There were no significant difference in serum vitamin A and D levels among pregnant women of different age groups(P>0.05). The abnormal rate of serum vitamin A in pregnant women aged 30-35 was higher than that in pregnant women aged <30 and >35, and the abnormal rate of serum vitamin D in pregnant women aged <30 was higher than that in pregnant women aged >35, but there were no significant differences(P>0.05). The serum vitamin A level of early and mid-pregnancy women was lower than that of late pregnancy, and the differences were statistically significant(P<0.05),the serum vitamin D level of early and mid-pregnancy women was higher than that of late pregnancy, and the differences were statistically significant(P<0.05). The serum vitamin D level of pregnant women in spring, summer and autumn was higher than that in winter(P<0.05), and the differences were statistically significant(P<0.05); the serum vitamin D level of pregnant women in spring was higher than that in autumn, and the differences were statistically significant(P<0.05). The abnormal rate of serum vitamin D in winter was higher than that in spring, summer and autumn, and the differences were statistically significant(P <0.05). Conclusion The analysis of vitamin A and D levels in pregnant women can provide a reference for the clinical prophylactic supplementation of vitamin A and D in pregnant women.
引文
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[19]杨瑞利,韩双,沈建军,等.西安地区妊娠期女性血清维生素A、E水平分析[J].海南医学,2017,28(9):1426-1428.
[20]Haq A,Wimalawansa SJ,Pludowski P,et al.Clinical practice guidelines for vitamin D in the United Arab Emirates[J].J Steroid Biochem Mol Biol,2018,175:4-11.
[2]邓松清,刘斌,王子莲.妊娠期高血压疾病孕妇孕中期血脂代谢研究[J].中山大学学报,2016,37(1):100-104.
[3]Contini C,Jansen M,Konig B,et al.Lipoprotein turnover and possible remnant accumulation in preeclampsia:insights from the Freiburg Preeclampsia H.E.L.P.-apheresis study[J].Lipids Health Dis,2018,17(1):49-60.
[4]Mendola P,Ghassabian A,Mills JL,et al.Retinol-binding protein 4 and lipids prospectively measured during early to mid-pregnancy in relation to preeclampsia and preterm birth risk[J].Am J Hypertension,2017,30(6):569-576.
[5]王旭芹.维生素A、D缺乏对妊娠糖尿病胰岛素抵抗及氧化应激的影响[D].重庆:重庆医科大学,2018.
[6]缪珺.维生素D缺乏与妊娠期糖尿病发病的相关性研究[J].实用临床医药杂志,2018,22(17):129-132.
[7]Zabul P,Wozniak M,Slominski AT,et al.A proposed moleeular mechanism of high dose vitamin D3 supplementation in prevention and treatment of preeclampsia[J].Int Mol Sci,2015,16(6):13 043-13 064.
[8]Hufnagl K,Jensen-Jarolim E.Vitamin A and D in al lergy:from experimental animal models and cellular studies to human disease[J].Allergo J Int,2018,27(3):72-78.
[9]Lopes da Silva S,Vellas B,Elemans S,et al.Plasma nutrient status of patients with Alzheimer′s disease:systematic review and metaanalysis[J].Alzheimers Dement,2014,10(4):485-502.
[10]Zeng J,Chen L,Wang Z,et al.Marginal vitamin A deficiency facilitates Alzheimer′s pathogenesis[J].ActaNeuropathol,2017,133(6):967-982.
[11]Schmitz J,West KP,Khatry SK,et al.Vitamin A supplementation in preschool children and risk of hearing loss as adolescents and young adults in rural Nepal:randomised trial cohort follow-up study[J].BMJ,2012,344:d7962.
[12]Ghenimi N,Beauvieux MC,Biran M,et al.Vitamin A deficiency in rats induces anatomic and metabolic changes comparable with those of neurodegenerative disorders[J].J Nutr,2009,139(4):696-702.
[13]Kumar S,Duester G.Retinoic acid signaling in periopticm esenchyme represses Wnt signaling via induction of Pitx2and Dkk2[J].Dev Biol,2010,340(1):67-74.
[14]王爱勤,阿依古丽·阿卜杜热西提,余江,等.维生素A水平与妊娠期高血压疾病的关系研究[J].临床和实验医学杂志,2018,17(2):118-121.
[15]Baca KM,Simhan HN,Platt RW,et al.Low maternal 25-hydroxyvitamin D concentration increases the risk of severe and mild preeclampsia[J].Annals Epidemiol,2016,26(12):853-857.e1.
[16]周海仙,许群,蔡平生.高剂量维生素D防治肥胖症孕妇妊娠期糖尿病的作用研究[J].中华全科医学,2017,15(11):1911-1914.
[17]Triunfo S,LanzoneA.Potential impact of maternal vitamin D status on obstetric well-being[J].J Endocrinol Invest,2016,39(1):37-44.
[18]Mohamed SA,El Andaloussi A,Al-Hendy A,et al.Vitamin D and corticotropin-releasing hormone in term and preterm birth:potential contributions to preterm labor and birth outcome[J].J Matern Fetal Neonatal Med,2018,31(21):2911-2917.
[19]杨瑞利,韩双,沈建军,等.西安地区妊娠期女性血清维生素A、E水平分析[J].海南医学,2017,28(9):1426-1428.
[20]Haq A,Wimalawansa SJ,Pludowski P,et al.Clinical practice guidelines for vitamin D in the United Arab Emirates[J].J Steroid Biochem Mol Biol,2018,175:4-11.