分析阿司匹林联合硫酸氢氯吡格雷口服治疗脑梗死的有效性和安全性
|
摘要
目的研究阿司匹林与硫酸氢氯吡格雷联合用于治疗脑梗死的临床效果以及安全性。方法在本院2015年2月至2016年1月间收治的脑梗死患者中随机抽取出150例作为观察对象,根据患者的意愿将其进行分组,分入到观察组和对照组中,其中观察组患者采用阿司匹林+硫酸氢氯吡格雷治疗,对照组患者给予阿司匹林治疗,对比分析两组患者的治疗总有效率、不良反应发生率、神经功能缺损程度等指标。结果观察组患者的临床疗效优于对照组,P<0.05;观察组患者在治疗1个月后的NIHSS评分明显更低,治疗6个月后的Barthel评分更高,P<0.05;而在不良反应方面,观察组患者的2.67%略低于对照组的5.33%,但P>0.05。结论在脑梗死的临床治疗,阿司匹林与硫酸氢氯吡格雷的配伍是合理的、有效的、安全的,有助于减轻患者的神经功能缺损程度,提高患者的生活自理能力,值得推广。
Objective To study the clinical effect and safety of aspirin and clopidogrel bisulfate in the treatment of cerebral infarction.Methods 150 cases of cerebral infarction patients treated in our hospital between February 2015 and January 2016 were randomly selected as the observation objects. According to patients 'willingness they were divided into observation group and control group. Observation group were treated with aspirin plus clopidogrel bisulfate,the control group were treated with aspirin,Total effective rate,incidence of adverse reactions,neurological deficits and other indicators of the two groups of patients were compared. Results The clinical effect of observation group was precede that of the control group( P < 0. 05). One month after the treatment,NIHSS score of the observation group was lower than the control group,but the Barthel score was higher than the control group,the differences were statistically significant( P < 0. 05). In respect of adverse reactions,it was 2. 67% in the observation group which was slightly lower than 2. 67% of the control group,however,it without statistically significant( P > 0. 05). Conclusions In the clinical treatment of cerebral infarction,the combination of aspirin and Clopidogrel Hydrogen Sulfate is reasonable,effective and safe,it is help to relieve the patient's neurologic impairment and improve patient self-care ability,worthy of promotion.
Objective To study the clinical effect and safety of aspirin and clopidogrel bisulfate in the treatment of cerebral infarction.Methods 150 cases of cerebral infarction patients treated in our hospital between February 2015 and January 2016 were randomly selected as the observation objects. According to patients 'willingness they were divided into observation group and control group. Observation group were treated with aspirin plus clopidogrel bisulfate,the control group were treated with aspirin,Total effective rate,incidence of adverse reactions,neurological deficits and other indicators of the two groups of patients were compared. Results The clinical effect of observation group was precede that of the control group( P < 0. 05). One month after the treatment,NIHSS score of the observation group was lower than the control group,but the Barthel score was higher than the control group,the differences were statistically significant( P < 0. 05). In respect of adverse reactions,it was 2. 67% in the observation group which was slightly lower than 2. 67% of the control group,however,it without statistically significant( P > 0. 05). Conclusions In the clinical treatment of cerebral infarction,the combination of aspirin and Clopidogrel Hydrogen Sulfate is reasonable,effective and safe,it is help to relieve the patient's neurologic impairment and improve patient self-care ability,worthy of promotion.
引文
[1]张东亚,胡亚妮,姜超,等.阿司匹林联合氯吡格雷治疗脑梗塞98例疗效分析[J].延安大学学报(医学科学版),2011,9(2):7-8.
[2]高抚刚,刘青山.阿司匹林联合氯吡格雷治疗脑梗塞30例临床观察[J].中国民族民间医药,2015,24(17):89-89.
[3]杨丽萍.波立维与脉血康药物联合疗法对冠心病合并脑梗塞患者凝血功能的影响研究[J].河北医学,2015,21(9):1494-1497.
[4]陈安,孙国香,王益波,等.长春西汀联合阿司匹林治疗急性脑梗死的疗效与安全性[J].河北医科大学学报,2011,32(3):326-327.
[5]周新荣.低分子肝素联合不同剂量阿司匹林治疗急性脑梗死的疗效和安全性比较[J].河北医科大学学报,2012,33(2):139-141.
[6]孙宏春,张锋.硫酸氢氯吡格雷联合依达拉奉治疗急性脑梗死的临床观察[J].中国当代医药,2011,18(10):51-52.
[7]王海林,黄庆彬,涂智毅,等.国产和进口硫酸氢氯吡格雷用于冠状动脉支架植入术后患者的效果对比[J].海峡药学,2015,27(6):185-187.
[8]郝素芳,夏云.注射用尤瑞克林与硫酸氢氯吡格雷联用治疗进展性脑梗死疗效观察[J].中国医药科学,2012,2(11):64-65.
[9]王特,孙新刚,刘运海,等.早期巴曲酶联合硫酸氢氯吡格雷治疗老年急性进展性脑梗死的疗效[J].中国老年学杂志,2012,32(23):5270-5271.
[10]夏敬高.氯吡格雷在缺血性脑卒中复发高危患者二级预防中的疗效和安全性[J].心脑血管病防治,2015,(3):217-219.
[2]高抚刚,刘青山.阿司匹林联合氯吡格雷治疗脑梗塞30例临床观察[J].中国民族民间医药,2015,24(17):89-89.
[3]杨丽萍.波立维与脉血康药物联合疗法对冠心病合并脑梗塞患者凝血功能的影响研究[J].河北医学,2015,21(9):1494-1497.
[4]陈安,孙国香,王益波,等.长春西汀联合阿司匹林治疗急性脑梗死的疗效与安全性[J].河北医科大学学报,2011,32(3):326-327.
[5]周新荣.低分子肝素联合不同剂量阿司匹林治疗急性脑梗死的疗效和安全性比较[J].河北医科大学学报,2012,33(2):139-141.
[6]孙宏春,张锋.硫酸氢氯吡格雷联合依达拉奉治疗急性脑梗死的临床观察[J].中国当代医药,2011,18(10):51-52.
[7]王海林,黄庆彬,涂智毅,等.国产和进口硫酸氢氯吡格雷用于冠状动脉支架植入术后患者的效果对比[J].海峡药学,2015,27(6):185-187.
[8]郝素芳,夏云.注射用尤瑞克林与硫酸氢氯吡格雷联用治疗进展性脑梗死疗效观察[J].中国医药科学,2012,2(11):64-65.
[9]王特,孙新刚,刘运海,等.早期巴曲酶联合硫酸氢氯吡格雷治疗老年急性进展性脑梗死的疗效[J].中国老年学杂志,2012,32(23):5270-5271.
[10]夏敬高.氯吡格雷在缺血性脑卒中复发高危患者二级预防中的疗效和安全性[J].心脑血管病防治,2015,(3):217-219.