229例患者中药注射剂致过敏性休克原因的循证分析
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摘要
目的:分析中药注射剂致过敏性休克的原因和特点,为临床合理用药提供参考。方法:检索中国知网《中国期刊全文数据库》中相关中药注射剂致过敏性休克的报道,分析和归纳就诊医院、诊断、过敏史、用法用量、联合用药情况、发生时间、抢救措施、转归情况等方面。结果:229例中药注射剂致过敏性休克的病例中,发生过敏性休克病例最多的是清开灵注射液88例;多数过敏性休克发生在用药后30 min内,基层医疗机构发生过敏性休克患者的病死率为最较高。结论:中药注射剂成分复杂,容易导致过敏性休克的发生,联合多药使用增加不良反应的风险,临床应加强用药过程中的监测,切实做到中药注射液的合理用药。
To analyze the reasons and characteristics of anaphylactic shock induced by Traditional Chinese Medicine(TCM) injection and to provide reference for clinical rational drug use. Methods:The domestic reports of anaphylactic shock from "Chinese Journal Full-text Database" in CNKI were retrieved and analyzed in respect of the hospital,diagnosis,allergic history,dosage,application method, drug combination,occurrence time, first-aid measures, regression,etc. Results:Among the 229 cases of anaphylactic shock, most cases of anaphylactic shock were induced by Qingkailing injection, a total of 88 cases; most of the anaphylactic shock occurred within 30 minutes after injection, the anaphylactic shock patients in grassroots medical institutions with high fatality rate. Conclusion:TCM injection composition is complicated, it is easy to cause the occurrence of anaphylactic shock and drug combinations increase the risk of adverse reactions. The process of drug use should be strictly monitored in order to reduce the incidence of anaphylactic shock caused by TCM injection ensuring the rational drug use.
To analyze the reasons and characteristics of anaphylactic shock induced by Traditional Chinese Medicine(TCM) injection and to provide reference for clinical rational drug use. Methods:The domestic reports of anaphylactic shock from "Chinese Journal Full-text Database" in CNKI were retrieved and analyzed in respect of the hospital,diagnosis,allergic history,dosage,application method, drug combination,occurrence time, first-aid measures, regression,etc. Results:Among the 229 cases of anaphylactic shock, most cases of anaphylactic shock were induced by Qingkailing injection, a total of 88 cases; most of the anaphylactic shock occurred within 30 minutes after injection, the anaphylactic shock patients in grassroots medical institutions with high fatality rate. Conclusion:TCM injection composition is complicated, it is easy to cause the occurrence of anaphylactic shock and drug combinations increase the risk of adverse reactions. The process of drug use should be strictly monitored in order to reduce the incidence of anaphylactic shock caused by TCM injection ensuring the rational drug use.
引文
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[7]牛晓军,中药注射剂不良反应现状、原因及预防[J].临床合理用药,2014,7(7):93-94.
[8]杨晖.中药注射剂不良反应的特点及因素[J].海峡药学,2007,19(7):112-113.
[9]金梅.31例清开灵注射液不良反应分析[J].中国药业,2003,(07):80-81.
[10]侯雪梅,邹娟.清开灵注射液过敏致死1例[J].医药导报,2000,19(05):437.
[2]宋荣芬.临床常见中药的不良反应[J].中华医药杂志,2004(4):7.
[3]中国执业药师协会.2011年度全国执业药师继续教育教材[M].北京:中国中医药出版社,2011:179.
[4]严炎中,徐雯宇,王佳良.中药注射剂不良反应原因分析[J].天津药学,2005.17(4):55-56.
[5]张雅杰,高敬茹,孙艳春,等,中药注射剂不良反应原因剖析与防范[J].黑龙江医药科学,2008,31(4):63-64.
[6]朱清碧,丹参液致新生儿过敏性休克并DIC的抢救和护理[J].贵阳医学院学报,2005,02(30):87-88.
[7]牛晓军,中药注射剂不良反应现状、原因及预防[J].临床合理用药,2014,7(7):93-94.
[8]杨晖.中药注射剂不良反应的特点及因素[J].海峡药学,2007,19(7):112-113.
[9]金梅.31例清开灵注射液不良反应分析[J].中国药业,2003,(07):80-81.
[10]侯雪梅,邹娟.清开灵注射液过敏致死1例[J].医药导报,2000,19(05):437.