单采血小板与冷沉淀凝血因子联合治疗急性大出血的效果
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摘要
目的探析单采血小板与冷沉淀凝血因子联合治疗急性大出血的效果。方法 60例急性大出血患者,随机分为对照组和观察组,各30例。对照组患者给予单采血小板治疗,观察组患者给予采血小板联合冷沉淀凝血因子治疗。比较两组患者治疗效果。结果观察组患者有效止血率93.33%明显高于对照组的73.33%,且止血时间(3.26±0.45)h明显短于对照组的(6.28±1.41)h,差异有统计学意义(P<0.05)。输注后1～2 h,观察组血浆凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)明显短于对照组,且纤维蛋白原(Fbg)、血小板计数(PLT)明显高于对照组,差异有统计学意义(P<0.05)。结论采血小板联合冷沉淀凝血因子治疗急性大出血可获得较好效果,有效止血率高,且可以缩短患者的止血时间,改善凝血指标,值得推广和应用。
Objective To discuss and analyze the effect of apheresis platelets combined with cryoprecipitated antihemophilic factor on acute massive hemorrhage. Methods A total of 60 patients with acute massive hemorrhage were randomly divided into control group and observation group, with 30 cases in each group. The control group received apheresis platelets for treatment, and the observation group received apheresis platelets combined with cryoprecipitated antihemophilic factor for treatment. The treatment effect in two groups was compared. Results The observation group had obviously higher effective hemostasis rate as 93.33% than 73.33% in the control group, and obviously shorter hemostasis time as(3.26±0.45) h than(6.28±1.41) h in the control group. Their difference was statistically significant(P<0.05). At 1～2 h after infusion, the observation group had obviously shorter plasma prothrombin time(PT), thrombin time(TT), activated partial thromboplastin time(APTT) than the control group, and obviously higher fibrinogen(Fbg), platelet count(PLT) than the control group. Their difference was statistically significant(P<0.05). Conclusion Combination of apheresis platelets and cryoprecipitated antihemophilic factor shows good effect in the treatment of acute massive hemorrhage, and it can shorten the hemostasis time of patients and improve the coagulation index. It is worth popularizing and applying.
Objective To discuss and analyze the effect of apheresis platelets combined with cryoprecipitated antihemophilic factor on acute massive hemorrhage. Methods A total of 60 patients with acute massive hemorrhage were randomly divided into control group and observation group, with 30 cases in each group. The control group received apheresis platelets for treatment, and the observation group received apheresis platelets combined with cryoprecipitated antihemophilic factor for treatment. The treatment effect in two groups was compared. Results The observation group had obviously higher effective hemostasis rate as 93.33% than 73.33% in the control group, and obviously shorter hemostasis time as(3.26±0.45) h than(6.28±1.41) h in the control group. Their difference was statistically significant(P<0.05). At 1～2 h after infusion, the observation group had obviously shorter plasma prothrombin time(PT), thrombin time(TT), activated partial thromboplastin time(APTT) than the control group, and obviously higher fibrinogen(Fbg), platelet count(PLT) than the control group. Their difference was statistically significant(P<0.05). Conclusion Combination of apheresis platelets and cryoprecipitated antihemophilic factor shows good effect in the treatment of acute massive hemorrhage, and it can shorten the hemostasis time of patients and improve the coagulation index. It is worth popularizing and applying.
引文
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[2]王肇亮.急性大失血患者的临床分析及输血治疗效果评价.中国医药指南, 2017, 15(32):180.
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[4]王敬波,胡旭梅,王伟,等.机采血小板联合冷沉淀输注对大出血患者凝血功能的影响.浙江临床医学, 2015, 17(6):870-871.
[5]罗宏山,任俊.机采血小板与冷沉淀单独及其联合输注对大失血患者凝血功能的影响.血栓与止血学, 2016, 22(3):321-323.
[6]徐勇锋.单采血小板与冷沉淀凝血因子联合输注在急性大出血治疗中的应用.中国校医, 2015, 29(6):451-452.
[2]王肇亮.急性大失血患者的临床分析及输血治疗效果评价.中国医药指南, 2017, 15(32):180.
[3]彭艳.单采血小板输注联合冷沉淀对急性大出血孕产妇各项凝血指标的影响.中国实验诊断学, 2017, 21(1):120-121.
[4]王敬波,胡旭梅,王伟,等.机采血小板联合冷沉淀输注对大出血患者凝血功能的影响.浙江临床医学, 2015, 17(6):870-871.
[5]罗宏山,任俊.机采血小板与冷沉淀单独及其联合输注对大失血患者凝血功能的影响.血栓与止血学, 2016, 22(3):321-323.
[6]徐勇锋.单采血小板与冷沉淀凝血因子联合输注在急性大出血治疗中的应用.中国校医, 2015, 29(6):451-452.