山慈菇抗乳腺癌的作用机制研究进展
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摘要
在中国乳腺癌已经成为上升幅度最快的恶性肿瘤,占女性死亡率的首位。目前化学药治疗乳腺癌存在不良反应大、耐药、容易侵袭及转移等缺点。山慈菇作为传统的中蒙医常用抗癌药,不仅能抑制肿瘤细胞的生长增殖、诱导凋亡、干扰侵袭及迁移,还能抗血管生成,目前已经广泛应用于临床。将近些年来山慈菇抗乳腺癌的作用机制进行综述,为山慈菇进一步应用于临床提供参考。
Breast cancer has become the fastest growing malignancy in China, accounting for the highest mortality rate among women.At present, western medicine in the treatment of breast cancer has many disadvantages such as high side effects, drug resistance, easy invasion, and metastasis. As a commonly used anticancer drug in traditional Chinese and Mongolian medicine, Iphigenia indica Kunth can not only inhibit the growth and proliferation of cancer cells, induce apoptosis, interfere with invasion and migration, but also resist angiogenesis, which have been used in clinical practice. In this paper, recent studies on anti-breast cancer mechanism of Iphigenia indica are summarized, which can provide reference for further clinical application of Iphigenia indica.
Breast cancer has become the fastest growing malignancy in China, accounting for the highest mortality rate among women.At present, western medicine in the treatment of breast cancer has many disadvantages such as high side effects, drug resistance, easy invasion, and metastasis. As a commonly used anticancer drug in traditional Chinese and Mongolian medicine, Iphigenia indica Kunth can not only inhibit the growth and proliferation of cancer cells, induce apoptosis, interfere with invasion and migration, but also resist angiogenesis, which have been used in clinical practice. In this paper, recent studies on anti-breast cancer mechanism of Iphigenia indica are summarized, which can provide reference for further clinical application of Iphigenia indica.
引文
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[21]王祥军,周士福,时伟峰,等.UPA和MMP-9在乳腺浸润性导管癌中的表达及其相关性[J].四川医学,2009,30(8):1200-1202.
[22]杨雪威,王思源,赵佳,等.山慈菇提取液对乳腺癌大鼠肿瘤组织血管内皮生长因子和基质金属蛋白酶-9表达的影响[J].中国临床药理学杂志,2018,34(7):838-840,856.
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[25]Locopo N,Fanelli M,Gasparini G.Clinical significance of angiogenic factor in breast cancer[J].Breast Cancer Res,1998,52(1/3):159-173.
[2]张勇.张宗歧治疗乳腺癌经验初探[J].山西中医学院学报,2008,9(2):38-40.
[3]秀兰,张彬.用蒙医理论分析乳腺增生病的病因病机[J].中国民族民间医药,2013,22(11):1,3.
[4]崔娜娟,王洪琪.清热解毒中药在恶性肿瘤防治中的机理研究与应用概况[J].甘肃中医,2005,18(3):43-44.
[5]陈藏器,尚志钧.本草拾遗[M].合肥:安徽科学技术出版社,2002.
[6]肖培根.新编中药志[M].北京:化学工业出版社,2000.
[7]赵惠,王志英,周仲瑛.周仲瑛从痰辨治恶性肿瘤用药分析[J].中医杂志,2015,56(9):740-742.
[8]夏文斌,薛震,李帅,等.杜鹃兰化学成份及肿瘤细胞毒活性研究[J].中国中药杂志,2005,30(23):1827-1830.
[9]徐小娟.山慈菇多糖、牛膝多糖对H22小鼠肝癌抑制作用及其抗肿瘤机制研究[D].长沙:湖南农业大学,2015.
[10]于治凡,刘英华,肖均财,等.山慈菇对甲状腺癌SW579细胞增殖及凋亡的影响[J].癌症进展,2018,16(10):1292-1294,1298.
[11]于林楠,翟宏颖.山慈菇提取物对结肠癌HT29细胞凋亡的影响[J].中国民族民间医药,2016,25(16):17-19.
[12]阮小丽,施大文.山慈菇的抗肿瘤及抑菌作用[J].中药材,2009,32(12):1886-1888.
[13]凌汶静.常用抗肿瘤中药的临床应用与规律探讨[D].北京:北京中医药大学,2015.
[14]刘银花,钟世军,曾涛,等.山慈菇提取液对小鼠4T1乳腺癌细胞抑制作用机制的研究[J].湖北农业科学,2016,55(1):134-137.
[15]牛晓雨,王璐,孙放,等.山慈菇水煎剂对乳腺癌MDA-MB-231细胞的影响[J].中成药,2018,40(1):197-200.
[16]郭淳,龚永杰,孙放,等.山慈菇水煎剂对人乳腺癌T-47D细胞增殖和迁移的影响[J].中医学报,2017,32(10):1832-1835.
[17]王亚茹,邓高松,李云,等.秋水仙碱对微管蛋白的作用机制及其细胞效应研究进展[J].西北植物学报,2010,30(12):2570-2576.
[18]Sherr C J,Roberts J M.CDK inhibitor:positive and negative regulators of G1 phase progression[J].Genes Dev,1999,13(12):1501-1512.
[19]戴大英,翟为溶.肿瘤抑制基因p53和p21WAF1/Cip1/Sdi1的相关性[J].临床与病例杂志,2000,20(6):440-442.
[20]刘琦,程旭锋,张新峰,等.山慈菇-蜂房药对抑制人乳腺癌MDA-MB-231细胞体外侵袭转移的机理研究[J].中药新药与临床药理,2014,25(4):389-392.
[21]王祥军,周士福,时伟峰,等.UPA和MMP-9在乳腺浸润性导管癌中的表达及其相关性[J].四川医学,2009,30(8):1200-1202.
[22]杨雪威,王思源,赵佳,等.山慈菇提取液对乳腺癌大鼠肿瘤组织血管内皮生长因子和基质金属蛋白酶-9表达的影响[J].中国临床药理学杂志,2018,34(7):838-840,856.
[23]Han B,Nakamura M,Moil I,et al.Urokinase-type plasminogen activator system and breast cancer[J].Oncol Rep,2005,14(1):105-112.
[24]Somiari S B,Shriver C D,Heckman C,et al.Plasma concentration and activity of matrix metalloproteinase 2and 9 in patients with breast disease,breast cancer and at risk of developing breast cancer[J].Cancer Lett,2006,233(1):98-107.
[25]Locopo N,Fanelli M,Gasparini G.Clinical significance of angiogenic factor in breast cancer[J].Breast Cancer Res,1998,52(1/3):159-173.