关于肢体缺血再灌注损伤评价指标的研究进展
|
摘要
肢体缺血是由肢体动脉梗阻引起的,常发生于周围动脉栓塞、动脉粥样硬化血栓形成和外伤性血管损伤等。随着肢体损伤病例的增加,缺血再灌注损伤也成为临床不可轻视的问题。为评价肢体缺血再灌注损伤的严重程度,需了解肢体缺血前后重要指标的变化,以便研究缺血再灌注的标准化评定。本文结合国内外关于缺血再灌注的相关研究,归纳和总结了现阶段缺血再灌注研究常用的一些评价指标。
Limb ischemia is caused by limb arterial obstruction and often occurs in peripheral arterial embolism,atherosclerotic thrombosis,and traumatic vascular injury. With the increase of limb injury,ischemia-reperfusion injury has become a problem that cannot be ignored in clinical practice. In order to evaluate the severity of limb ischemia-reperfusion injury,it is necessary to understand the changes of important indicators before and after limb ischemia,which will be helpful in the establishment of standardized assessment of ischemia-reperfusion in the future. Here,the evaluation indexes commonly used in the research of ischemia-reperfusion at present stage are described in this review based on the related researches on ischemia-reperfusion at home and abroad.
Limb ischemia is caused by limb arterial obstruction and often occurs in peripheral arterial embolism,atherosclerotic thrombosis,and traumatic vascular injury. With the increase of limb injury,ischemia-reperfusion injury has become a problem that cannot be ignored in clinical practice. In order to evaluate the severity of limb ischemia-reperfusion injury,it is necessary to understand the changes of important indicators before and after limb ischemia,which will be helpful in the establishment of standardized assessment of ischemia-reperfusion in the future. Here,the evaluation indexes commonly used in the research of ischemia-reperfusion at present stage are described in this review based on the related researches on ischemia-reperfusion at home and abroad.
引文
[1] NAKAZATO P C G,VICTORINO J P,FINA C F,et al. Liver ischemia and reperfusion injury. Pathophysiology and new horizons in preconditioning and therapy [J]. Acta Cir Bras,2018,33(8):723-735.
[2] LI Nuo,QIN Sina,XIE Lu,et al. Elevated serum potassium concen-tration alleviates cerebral ischemia-reperfusion injury via mitochondrial preservation [J]. Cell Physiol and Biochem,2018,48(4):1664-1674.
[3] SONG Chunli,LIU Bin,DIAO Hongying,et al. The protective effect of microRNA-320 on left ventricular remodeling after myocardial ischemia-reperfusion injury in the rat model [J]. Int J Mol Sci,2014,15(10):17442-17456.
[4] 王崇文. 肢体缺血性再灌注损伤的新型动物模型制作[D]. 乌鲁木齐:新疆医科大学,2012.
[5] KIRISCI M,OKTAR G L,OZOGUL C,et al. Effects of adrenome-dullin and vascular endothelial growth factor on ischemia/reperfusion injury in skeletal muscle in rats [J]. J Surg Res,2013,185(1):56-63.
[6] XU Yongle,ZHANG Minhong,GUO Wei,et al. MicroRNA-19 restores vascular endothelial cell function in lower limb ischemia-reperfusion injury through the KLF10-dependent TGF-β1/Smad signaling pathway in rats [J]. J Cell Biochem,2018,doi:10.1002/jcb.27207.
[7] XIANG Yijia,YE Shiyong,CAI Changhong,et al. Salvianolic acid a attenuates limb ischemia/reperfusion injury in skeletal muscle of rats [J]. Biomed Pharmacother,2018,97:551-556.
[8] ZHANG Yan,LI Chengzhi,ZHANG Hong,et al. Color-coded digital subtraction angiography for assessing acute skeletal muscle ischemia-reperfusion injury in a rabbit model [J]. Acad Radiol,2018,S1076-6332(18)30133-30138.
[9] WERNER R A,MAYA Y,RISCHPLER C,et al. Sympathetic nerve damage and restoration after ischemia-reperfusion injury as assessed by (11)C-hydroxyephedrine [J]. Eur J Nucl Med Mol Imaging,2016,43(2):312-318.
[10] CARNEMOLLA R,VILLA C H,GREINEDER C F,et al. Targeting thrombomodulin to circulating red blood cells augments its protective effects in models of endotoxemia and ischemia-reperfusion injury [J]. Faseb J,2017,31(2):761-770.
[11] ?ZER A,DEMIRTAS H,?OMU F M,et al. Protective effect of erdosteine on erythrocyte deformability in a rat model of lower limb ischemia/reperfusion injury [J]. Turk J Med Sci,2018,48(1):187-190.
[12] SIVGIN V,KUCUK A,COMU F M,et al. Effects of intravenous ibuprofen and lornoxicam on erythrocyte deformability in rats undergoing hind limb ischemia reperfusion injury [J]. Bratisl Med J,2016,117(12):722-725.
[13] WU Ye,ZHANG Minhong,XUE Yan,et al. Effect of microRNA- 26a on vascular endothelial cell injury caused by lower extremity ischemia-reperfusion injury through the AMPK pathway by targeting PFKFB3 [J]. J Cell Physiol,2018,doi:10.1002/jcp.27108.
[14] HSIEH K F,SHIH J M,SHIH Y M,et al. Arginine administration increases circulating endothelial progenitor cells and attenuates tissue injury in a mouse model of hind limb ischemia/reperfusion [J]. Nutrition,2018,55-56:29-35.
[15] WEINGARDEN S I,LOUIS D L,WAYLONIS G W. Electromyo-graphic changes in postmeniscectomy patients.Role of the pneumatic tourniquet [J]. JAMA,1979,241(12):1248-1250.
[16] SAUNDERS KC,LOUIS D I,WEINGARDEN S I,et al. Effect of tourniquet time on post-operative quadriceps function [J]. Clin Orthop,1979,143: 194-199.
[17] KREBS D E. Isokinetic,electrophysiologic,and clinical function relationships following tourniquet-aided knee arthrotomy [J]. Phys Ther,1989,69( 10): 803-815.
[18] 胡跃林,郑菊阳,于长隆,等. 止血带缺血预处理对大鼠肢体缺血再灌注损伤的保护作用——电生理学研究[J]. 中国运动医学杂志,2003,22(3):153-155.
[19] 师继红,黄耀添,徐新智. 手术治疗周围神经缺血再灌注损伤的电生理研究[J]. 中华显微外科杂志,1997,16(2):116-119.
[20] 富玲,黄波,李易嶙,等. 硫辛酸干预坐骨神经缺血再灌注损伤后的电生理变化[J]. 中国组织工程研究,2017,21(12):1838-1842.
[21] ITOH Y,AKATAKI K,MITA K,et al. Frequency response model of skeletal muscle and its association with contractile properties of skeletal muscle [J]. J Electromyogr Kinesiol,2013,23(3):572-579.
[22] KOCMAN E A,OZATIK O,SAHIN A,et al. Effects of ischemic preconditioning protocols on skeletal muscle ischemia-reperfusion injury [J]. J Surg Res,2015,193(2):942-952.
[23] MONROY GUIZAR E A,GARCIA BENAVIDES L,AMBRIZ PLASCENCIA A R,et al. Effect of alpha-lipoic acid on clinical and neurophysiologic recovery of carpal tunnel syndrome: a double-blind,randomized clinical trial [J]. J Med Food,2018,21(5):521-526.
[24] 彭军,张连元,门秀丽,等. 大鼠肢体缺血再灌注过程中血及骨骼肌的相应指标变化[J]. 中国病理生理杂志,2005,21(7):1424-1425.
[25] BOSCO G,YANG Zhongjin,NANDI J,et al. Effects of hyperbaric oxygen on glucose,lactate,glycerol and anti-oxidant enzymes in the skeletal muscle of rats during ischaemia and reperfusion [J]. Clin Exp Pharmacol Physiol,2010,34(1/2):70-76.
[26] TAKHTFOOLADI H A,TAKHTFOOLADI M A,KARIMI P,et al. Influence of tramadol on ischemia-reperfusion injury of rats? skeletal muscle [J]. Int J Surg,2014,12(9):963-968.
[27] 孙任任,张赢予,赵轶卓,等. 重组人Elafin对大鼠肝脏缺血再灌注损伤的保护作用[J]. 实验动物科学,2010,27(5):23-25.
[28] WHITTINGTON H J,OSTROESKI P J,MCANDREW D J,et al. Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia-reperfusion [J]. Cardiovasc Res,2018,114(6):858-869.
[29] 秦莎莎,余梦黎,廖金明,等. 羟基红花黄色素A与芍药苷联合用药对大鼠脑缺血再灌注损伤的保护作用[J]. 广东药科大学学报,2016,32(6):747-751.
[30] LUAN Xiaoqian,CHEN Huijun,QIU Huihua,et al. Association between serum malondialdehyde levels and depression during early methamphetamine withdrawal [J]. Neurosci Lett,2018,687:22-25.
[31] SOUZA P C,EBD S,MOTTA G L,et al. Combined effects of melatonin and topical hypothermia on renal ischemia-reperfusion injury in rats [J]. Acta Cirurgica Brasileira,2018,33(3):197-206.
[32] CAI Zhaobin,SHI Tinging,ZHUANG Rangxiao,et al. Protective effect of N-acetylcysteine activated carbon release microcapsule on myocardial ischemia-reperfusion injury in rats [J]. Exp Ther Med,2018,15(2):1809-1818.
[33] CAI Jing,JIANG Yu,ZHANG Meng,et al. Protective effects of mitochondrion-targeted peptide SS-31 against hind limb ischemia-reperfusion injury [J]. J Physiol Biochem,2018,74(2):335-343.
[34] GAO Chao,LIU Yi,YU Qiujun,et al. TNF-α antagonism ameliorates myocardial ischemia-reperfusion injury in mice by upregulating adiponectin [J]. Am J Physiol Heart Circ Physiol,2015,308(12):H1583-1591.
[35] HOU Ling,CHEN Gang,FENG Biao,et al. Small interfering RNA targeting TNF-α gene significantly attenuates renal ischemia-reperfusion injury in mice [J]. J Huazhong Univ Sci Tech Med Sci,2016,36(5):634-638.
[36] LOPEZ-NEBLINA F,TOLEDO-PEREYRA L H,TOLEDO A H,et al. Ryanodine receptor antagonism protects the ischemic liver and modulates TNF-alpha and IL-10 [J]. J Surg Res,2007,140(1):121-128.
[37] ZHOU Hong,JIANG Chunhui,GU Lei,et al. Influence of melatonin on IL-1Ra gene and IL-1 expression in rats with liver ischemia reperfusion injury [J]. Biomed Rep,2016,4(6):667-672.
[38] FOSTER A D,VICENTE D,SEXTON J J,et al. Administration of FTY720 during tourniquet-induced limb ischemia reperfusion injury attenuates systemic inflammation [J]. Mediators Inflamm,2017,2017:4594035.
[39] 程曼,刘朝琦,董志萍,等. 炎症因子在缺血再灌注大鼠海马各亚区表达研究[J]. 军事医学,2017,41(12):956-961.
[40] 郭志祥,汪欢,张成鑫,等. 大鼠心肌缺血再灌注损伤过程中血流动力学及炎症因子的表达变化[J]. 山东医药,2014(44):45-47.
[2] LI Nuo,QIN Sina,XIE Lu,et al. Elevated serum potassium concen-tration alleviates cerebral ischemia-reperfusion injury via mitochondrial preservation [J]. Cell Physiol and Biochem,2018,48(4):1664-1674.
[3] SONG Chunli,LIU Bin,DIAO Hongying,et al. The protective effect of microRNA-320 on left ventricular remodeling after myocardial ischemia-reperfusion injury in the rat model [J]. Int J Mol Sci,2014,15(10):17442-17456.
[4] 王崇文. 肢体缺血性再灌注损伤的新型动物模型制作[D]. 乌鲁木齐:新疆医科大学,2012.
[5] KIRISCI M,OKTAR G L,OZOGUL C,et al. Effects of adrenome-dullin and vascular endothelial growth factor on ischemia/reperfusion injury in skeletal muscle in rats [J]. J Surg Res,2013,185(1):56-63.
[6] XU Yongle,ZHANG Minhong,GUO Wei,et al. MicroRNA-19 restores vascular endothelial cell function in lower limb ischemia-reperfusion injury through the KLF10-dependent TGF-β1/Smad signaling pathway in rats [J]. J Cell Biochem,2018,doi:10.1002/jcb.27207.
[7] XIANG Yijia,YE Shiyong,CAI Changhong,et al. Salvianolic acid a attenuates limb ischemia/reperfusion injury in skeletal muscle of rats [J]. Biomed Pharmacother,2018,97:551-556.
[8] ZHANG Yan,LI Chengzhi,ZHANG Hong,et al. Color-coded digital subtraction angiography for assessing acute skeletal muscle ischemia-reperfusion injury in a rabbit model [J]. Acad Radiol,2018,S1076-6332(18)30133-30138.
[9] WERNER R A,MAYA Y,RISCHPLER C,et al. Sympathetic nerve damage and restoration after ischemia-reperfusion injury as assessed by (11)C-hydroxyephedrine [J]. Eur J Nucl Med Mol Imaging,2016,43(2):312-318.
[10] CARNEMOLLA R,VILLA C H,GREINEDER C F,et al. Targeting thrombomodulin to circulating red blood cells augments its protective effects in models of endotoxemia and ischemia-reperfusion injury [J]. Faseb J,2017,31(2):761-770.
[11] ?ZER A,DEMIRTAS H,?OMU F M,et al. Protective effect of erdosteine on erythrocyte deformability in a rat model of lower limb ischemia/reperfusion injury [J]. Turk J Med Sci,2018,48(1):187-190.
[12] SIVGIN V,KUCUK A,COMU F M,et al. Effects of intravenous ibuprofen and lornoxicam on erythrocyte deformability in rats undergoing hind limb ischemia reperfusion injury [J]. Bratisl Med J,2016,117(12):722-725.
[13] WU Ye,ZHANG Minhong,XUE Yan,et al. Effect of microRNA- 26a on vascular endothelial cell injury caused by lower extremity ischemia-reperfusion injury through the AMPK pathway by targeting PFKFB3 [J]. J Cell Physiol,2018,doi:10.1002/jcp.27108.
[14] HSIEH K F,SHIH J M,SHIH Y M,et al. Arginine administration increases circulating endothelial progenitor cells and attenuates tissue injury in a mouse model of hind limb ischemia/reperfusion [J]. Nutrition,2018,55-56:29-35.
[15] WEINGARDEN S I,LOUIS D L,WAYLONIS G W. Electromyo-graphic changes in postmeniscectomy patients.Role of the pneumatic tourniquet [J]. JAMA,1979,241(12):1248-1250.
[16] SAUNDERS KC,LOUIS D I,WEINGARDEN S I,et al. Effect of tourniquet time on post-operative quadriceps function [J]. Clin Orthop,1979,143: 194-199.
[17] KREBS D E. Isokinetic,electrophysiologic,and clinical function relationships following tourniquet-aided knee arthrotomy [J]. Phys Ther,1989,69( 10): 803-815.
[18] 胡跃林,郑菊阳,于长隆,等. 止血带缺血预处理对大鼠肢体缺血再灌注损伤的保护作用——电生理学研究[J]. 中国运动医学杂志,2003,22(3):153-155.
[19] 师继红,黄耀添,徐新智. 手术治疗周围神经缺血再灌注损伤的电生理研究[J]. 中华显微外科杂志,1997,16(2):116-119.
[20] 富玲,黄波,李易嶙,等. 硫辛酸干预坐骨神经缺血再灌注损伤后的电生理变化[J]. 中国组织工程研究,2017,21(12):1838-1842.
[21] ITOH Y,AKATAKI K,MITA K,et al. Frequency response model of skeletal muscle and its association with contractile properties of skeletal muscle [J]. J Electromyogr Kinesiol,2013,23(3):572-579.
[22] KOCMAN E A,OZATIK O,SAHIN A,et al. Effects of ischemic preconditioning protocols on skeletal muscle ischemia-reperfusion injury [J]. J Surg Res,2015,193(2):942-952.
[23] MONROY GUIZAR E A,GARCIA BENAVIDES L,AMBRIZ PLASCENCIA A R,et al. Effect of alpha-lipoic acid on clinical and neurophysiologic recovery of carpal tunnel syndrome: a double-blind,randomized clinical trial [J]. J Med Food,2018,21(5):521-526.
[24] 彭军,张连元,门秀丽,等. 大鼠肢体缺血再灌注过程中血及骨骼肌的相应指标变化[J]. 中国病理生理杂志,2005,21(7):1424-1425.
[25] BOSCO G,YANG Zhongjin,NANDI J,et al. Effects of hyperbaric oxygen on glucose,lactate,glycerol and anti-oxidant enzymes in the skeletal muscle of rats during ischaemia and reperfusion [J]. Clin Exp Pharmacol Physiol,2010,34(1/2):70-76.
[26] TAKHTFOOLADI H A,TAKHTFOOLADI M A,KARIMI P,et al. Influence of tramadol on ischemia-reperfusion injury of rats? skeletal muscle [J]. Int J Surg,2014,12(9):963-968.
[27] 孙任任,张赢予,赵轶卓,等. 重组人Elafin对大鼠肝脏缺血再灌注损伤的保护作用[J]. 实验动物科学,2010,27(5):23-25.
[28] WHITTINGTON H J,OSTROESKI P J,MCANDREW D J,et al. Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia-reperfusion [J]. Cardiovasc Res,2018,114(6):858-869.
[29] 秦莎莎,余梦黎,廖金明,等. 羟基红花黄色素A与芍药苷联合用药对大鼠脑缺血再灌注损伤的保护作用[J]. 广东药科大学学报,2016,32(6):747-751.
[30] LUAN Xiaoqian,CHEN Huijun,QIU Huihua,et al. Association between serum malondialdehyde levels and depression during early methamphetamine withdrawal [J]. Neurosci Lett,2018,687:22-25.
[31] SOUZA P C,EBD S,MOTTA G L,et al. Combined effects of melatonin and topical hypothermia on renal ischemia-reperfusion injury in rats [J]. Acta Cirurgica Brasileira,2018,33(3):197-206.
[32] CAI Zhaobin,SHI Tinging,ZHUANG Rangxiao,et al. Protective effect of N-acetylcysteine activated carbon release microcapsule on myocardial ischemia-reperfusion injury in rats [J]. Exp Ther Med,2018,15(2):1809-1818.
[33] CAI Jing,JIANG Yu,ZHANG Meng,et al. Protective effects of mitochondrion-targeted peptide SS-31 against hind limb ischemia-reperfusion injury [J]. J Physiol Biochem,2018,74(2):335-343.
[34] GAO Chao,LIU Yi,YU Qiujun,et al. TNF-α antagonism ameliorates myocardial ischemia-reperfusion injury in mice by upregulating adiponectin [J]. Am J Physiol Heart Circ Physiol,2015,308(12):H1583-1591.
[35] HOU Ling,CHEN Gang,FENG Biao,et al. Small interfering RNA targeting TNF-α gene significantly attenuates renal ischemia-reperfusion injury in mice [J]. J Huazhong Univ Sci Tech Med Sci,2016,36(5):634-638.
[36] LOPEZ-NEBLINA F,TOLEDO-PEREYRA L H,TOLEDO A H,et al. Ryanodine receptor antagonism protects the ischemic liver and modulates TNF-alpha and IL-10 [J]. J Surg Res,2007,140(1):121-128.
[37] ZHOU Hong,JIANG Chunhui,GU Lei,et al. Influence of melatonin on IL-1Ra gene and IL-1 expression in rats with liver ischemia reperfusion injury [J]. Biomed Rep,2016,4(6):667-672.
[38] FOSTER A D,VICENTE D,SEXTON J J,et al. Administration of FTY720 during tourniquet-induced limb ischemia reperfusion injury attenuates systemic inflammation [J]. Mediators Inflamm,2017,2017:4594035.
[39] 程曼,刘朝琦,董志萍,等. 炎症因子在缺血再灌注大鼠海马各亚区表达研究[J]. 军事医学,2017,41(12):956-961.
[40] 郭志祥,汪欢,张成鑫,等. 大鼠心肌缺血再灌注损伤过程中血流动力学及炎症因子的表达变化[J]. 山东医药,2014(44):45-47.