何氏养肾方对中期糖尿病肾病中医症候积分及生化指标的影响
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摘要
目的:探讨何氏养肾方对III、IV期糖尿病肾病(DN)中医症候积分及生化指标的影响。方法:将60例中期DN患者随机分为A组和B组,各30例。A组在基础治疗上予贝那普利治疗,B组在A组治疗上联合何氏养肾方治疗。比较两组治疗对中医症候积分及生化指标的影响。结果:(1)两组中医证候积分均降低,且B组降低更为明显(P<0.05)。(2)B组总有效率(86.67%)高于A组(66.67%)(P<0.05);(3)两组24h尿蛋白定量(24h UP)、24h尿微量白蛋白(24h U-MA)、血肌酐(Scr)水平较治疗前下降,B组降低程度大于A组(P<0.05)。结论:何氏养肾方可改善中期糖尿病肾病中医症状及生化指标。
Objective:To investigate the effect of on TCM syndromes score and biochemical indexes of middle stage diabetic nephropathy(DN).Methods:60 patients with intermediate DN were randomly divided into group A and group B,with 30 patients each. Group A was treated with benazepril on the basis of treatment,Group B was treated with Heshiyangshen prescription on the basis of the group A. The effects of treatment on TCM syndromes and biochemical indexes were compared between the two groups. Results:(1)The scores of TCM syndromes were reduced in both groups,and the decrease was more obvious in group B(P <0.05).(2)Total efficiency of Group B(90.00%)was significantly higher than that of the group A(66.67%)(P<0.05).(3)The 24 h urinary protein(24 hUP),24 hour urinary microalbumin(24 h U-MA)and Scr were reduced in both groups compared with that before treatment,and the reduction degree in group B was higher than that in group A(P<0.05). Conclusion:Heshiyangshen prescription could be improved the TCM symptoms and biochemical indexes in patients with middle stage diabetic nephropathy.
Objective:To investigate the effect of on TCM syndromes score and biochemical indexes of middle stage diabetic nephropathy(DN).Methods:60 patients with intermediate DN were randomly divided into group A and group B,with 30 patients each. Group A was treated with benazepril on the basis of treatment,Group B was treated with Heshiyangshen prescription on the basis of the group A. The effects of treatment on TCM syndromes and biochemical indexes were compared between the two groups. Results:(1)The scores of TCM syndromes were reduced in both groups,and the decrease was more obvious in group B(P <0.05).(2)Total efficiency of Group B(90.00%)was significantly higher than that of the group A(66.67%)(P<0.05).(3)The 24 h urinary protein(24 hUP),24 hour urinary microalbumin(24 h U-MA)and Scr were reduced in both groups compared with that before treatment,and the reduction degree in group B was higher than that in group A(P<0.05). Conclusion:Heshiyangshen prescription could be improved the TCM symptoms and biochemical indexes in patients with middle stage diabetic nephropathy.
引文
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[4]邓丽娥,何世东.何氏养肾方对慢性肾脏病患者炎症指标的影响[J].中医临床研究,2017,9(33):104-105.
[5]邓丽娥,李强,何世东,等.何氏调补脾肾、化瘀通络法干预CKD的思想研究[J].中国中西医结合肾病杂志,2015(9):760-762.
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[9]武士锋,王自敏.王自敏从“瘀”论治慢性肾脏病经验[J].上海中医药杂志,2010,44(6):19-20.
[2]胡长军,石岩.中医药治疗糖尿病肾病的研究进展[J].光明中医,2014,29(6):1162-1163.
[3]朱海慧,叶学锋,谢春光,等.清热益气通络方治疗糖尿病肾病大鼠蛋白尿的实验研究[J].西安交通大学学报(医学版),2014,35(4):537-541.
[4]邓丽娥,何世东.何氏养肾方对慢性肾脏病患者炎症指标的影响[J].中医临床研究,2017,9(33):104-105.
[5]邓丽娥,李强,何世东,等.何氏调补脾肾、化瘀通络法干预CKD的思想研究[J].中国中西医结合肾病杂志,2015(9):760-762.
[6]孔媛媛,薛志强,严功辉.前列地尔联合卡托普利治疗老年糖尿病肾病蛋白尿的疗效分析[J].黑龙江医药,2015,27(4):814-815.
[7]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:157-162,233-237.
[8]中华中医药学会.糖尿病肾病中医防治指南[M].北京:中国中医药出版社,2011.
[9]武士锋,王自敏.王自敏从“瘀”论治慢性肾脏病经验[J].上海中医药杂志,2010,44(6):19-20.