基于微机电系统的高深宽比气相微色谱柱
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摘要
色谱柱的微型化是实现气相色谱仪微小型化必须要解决的关键问题之一。该文基于微机电系统技术设计制作了一种具有高深宽比微沟道的气相微色谱柱。通过COMSOL软件进行仿真分析,得出气相微色谱柱具有均匀的流速场分布。测试结果表明,该气相微色谱柱成功分离了烷烃类气体混合物及苯系物,其理论塔板数可达14 028 plates/m,C7~C8的分离度最高,为10.82。这种气相微色谱柱由于具有体积小、能耗低、分离性能好等优点,可望在微小型气相色谱仪上获得应用。
Miniaturization of gas chromatography(GC)columns is one of the key problems associated with microminiaturization of a chromatograph. In this study,a GC column with highaspect-ratio microchannel based on micro-electro-mechanical system(MEMS)technology has been designed and manufactured. Simulation and analysis by the COMSOL software revealed that the GC column has even velocity field distribution,which is crucial for improving the separation efficiency of the column. The results show that heavy hydrocarbons(C6-C10)and compounds of benzene series can be successfully separated. The number of theoretical plate is14 028 plates/m,and the resolution of C7-C8 is 10. 82. Due to its advantages of smaller volume,lower energy consumption,and better separation performance,the GC column can be applied in micro gas chromatography.
Miniaturization of gas chromatography(GC)columns is one of the key problems associated with microminiaturization of a chromatograph. In this study,a GC column with highaspect-ratio microchannel based on micro-electro-mechanical system(MEMS)technology has been designed and manufactured. Simulation and analysis by the COMSOL software revealed that the GC column has even velocity field distribution,which is crucial for improving the separation efficiency of the column. The results show that heavy hydrocarbons(C6-C10)and compounds of benzene series can be successfully separated. The number of theoretical plate is14 028 plates/m,and the resolution of C7-C8 is 10. 82. Due to its advantages of smaller volume,lower energy consumption,and better separation performance,the GC column can be applied in micro gas chromatography.
引文
[1]Wang T.[MS Dissertation].Zhejiang:Zhejiang University,2016王涛.[硕士学位论文].浙江:浙江大学,2016
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[22]Li T.Chinese Journal of Chromatography,2003,21(3):299李彤.色谱,2003,21(3):299
[23]Pharmacopoeia Commission of People’s Republic of China.Pharmacopoeia of People’s Republic of China,Part 4.Beijing:China Medical Science Press,2015:64国家药典委员会.中华人民共和国药典,四部.北京:中国医药科技出版社,2015:64
[2]Li Y.[PhD Dissertation].Chendu:University of Electronic Science and Technology of China,2014李臆.[博士学位论文].成都:电子科技大学,2014
[3]Guan Y F,Wang J W,Duan C H,Chinese Journal of Chromatography,2009,27(5):592关亚风,王建伟,段春凤.色谱,2009,27(5):592
[4]Overton E B,Dharmasena H P,Ehrmann U,et al.Field Anal Chem Technol,1996,1(2):87
[5]Narayanan S,Alfeeli B,Agah M.IEEE Sens J,2012,12(6):1893
[6]Kim S K,Chang H,Zellers E T.Anal Chem,2011,83(18):7198
[7]Haghighi F,Talebpour Z,Sanati-Nezhad A.Lab Chip,2015,15(12):2559
[8]Shakeel H,Wang D,Heflin J R,et al.IEEE Sens J,2014,14(10):3352
[9]Qin Y,Gianchandani Y B.J Microelectromech Syst,2014,23(4):980
[10]Akbar M,Shakeel H,Agah M.Lab Chip,2015,15(7):1748
[11]Iwaya T,Akao S,Sakamoto T,et al.Jpn Appl Phys,2012,51(7S):07GC24
[12]Haudebourg R,Vial J,Thiebaut D,et al.Anal Chem,2012,85(1):114
[13]Yuan H,Du X,Li Y,et al//Bhuyan M S,et al.IEEE International Conference on Manipulation,Manufacturing and Measurement on the Nanoscale(3M-NANO).Piscataway:IEEE Press,2016:283
[14]Terry S C,Jerman J H,Angell J B.IEEE Trans Electron Devices,1979,26(12):1880
[15]Radadia A D,Salehi-Khojin A,Masel R I,et al.Sens Actuator B-Chem,2010,150(1):456
[16]Reidy S,Lambertus G,Reece J,et al.Anal Chem,2006,78(8):2623
[17]Radadia A D,Masel R I,Shannon M A,et al.Anal Chem,2008,80(11):4087
[18]Lee C Y,Liu C C,Chen S C,et al.Microsyst Technol,2011,17(4):523
[19]Li Y,Du X,Wang Y,et al.RSC Adv,2014,4(8):3742
[20]Li Y,Zhang R,Wang T,et al.Talanta,2016,154:99
[21]Golay M J E.Gas Chromatography.New York:Academic Press,1958
[22]Li T.Chinese Journal of Chromatography,2003,21(3):299李彤.色谱,2003,21(3):299
[23]Pharmacopoeia Commission of People’s Republic of China.Pharmacopoeia of People’s Republic of China,Part 4.Beijing:China Medical Science Press,2015:64国家药典委员会.中华人民共和国药典,四部.北京:中国医药科技出版社,2015:64