《维生素和矿物质在骨骼健康中的应用——2018年AACE/ACE立场声明》解读
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摘要
近年来的研究表明,营养在骨质疏松症的发生、发展中发挥了重要作用。最近,美国临床内分泌医师协会和美国内分泌学会(AACE/ACE)联合发布了《维生素和矿物质在骨骼健康中的应用-AACE/ACE立场声明》,并于2018年7月发表在Endocrine Practice杂志上,旨在为骨骼健康所需最佳营养状态进行定义和规范。本文就该立场声明的主要内容进行简要解读。
引文
[1] Cosman F,de Beur SJ,Le Boff MS,et al. Clinician's guide to prevention and treatment of osteoporosis[J].Osteoporos Int,2014,25:2359-2381.
[2] Heaney RP. Methods in nutrition science:the bone remodeling transient:interpreting interventions involving bone-related nutrients[J]. Nutr Rev, 2001, 59:327-334.
[3] Bailey RL,Gahche JJ,Lentino CV,et al. Dietary supplement use in the United States[J]. J Nutr,2011,141:261-266.
[4] Marques-Vidal P,Pecoud A,Hayoz D,et al. Prevalence and characteristics of vitamin or dietary supplement users in Lausanne, Switzerland:the Co Laus study[J]. Eur J Clin Nutr,2009,63:273-281.
[5] Rovira MA,Grau M,Castaner O,et al. REGICOR Investigators Dietary supplement use and health-related behaviors in a Mediterranean population[J]. J Nutr Educ Behav,2013,45:386-391.
[6] Hurley DL,Binkley N,Camacho PM,et al. The use of vitamins and minerals in skeletal health:American Association of Clinical Endocrinologists and the American College of Endocrinology(AACE/ACE)osition statement[J]. Endocr Pract,2018,24:915-924.
[7] Kovacs CS. Calcium and bone metabolism disorders during pregnancy and lactation[J]. Endocrinol Metab Clin N Am,2011,40:795-826.
[8] Goulding A,Rockell JE,Black RE,et al. Children who avoid drinking cow's milk are at increased risk for prepubertal bone fractures[J]. J Am Diet Assoc,2004,104:250-253.
[9] Matkovic V,Goel PK,Badenhop-Stevens NE,et al.Calcium supplementation and bone mineral density in females from childhood to young adulthood:a randomized controlled trial[J]. Am J Clin Nutr,2005,81:175-188.
[10] Avenell A,Mak JC,O'Connell D. Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men[J]. Cochrane Database Syst Rev,2014,14:CD000227.
[11] Weaver CM,Alexander DD,Boushey CJ,et al. Calcium plus vitamin D supplementation and risk of fractures:an updated meta-analysis from the National Osteoporosis Foundation[J]. Osteoporos Int,2016,27:367-376.
[12] Calvo MS,Uribarri J. Public health impact of dietary phosphorus excess on bone and cardiovascular health in the general population[J]. Am J Clin Nutr,2013,98:6-15.
[13] Lee AW,Cho SS. Association between phosphorus intake and bone health in the NHANES population[J].Nutr J,2015,14:28.
[14] Rosanoff A,Weaver CM,Rude RK. Suboptimal magnesium status in the United States:are the health consequences underestimated?[J]. Nutr Rev, 2012,70:153-164.
[15] Orchard TS,Larson JC,Alghothani N,et al. Magne-sium intake,bone mineral density,and fractures:results from the Women's Health Initiative Observational Study[J]. Am J Clin Nutr,2014,99:926-933.
[16] Carbone L,Johnson KC,Huang Y,et al. Sodium intake and osteoporosis. Findings from the Women's Health Initiative[J]. J Clin Endocrinol Metab,2016,101:1414-1421.
[17] Carmel AS,Shieh A,Bang H,et al. 2011 The 25(OH)D level needed to maintain a favorable bisphosphonate response is> 33 ng/m L[J]. J Bone Miner Res,2012,23:2479-2487.
[18] Sempos CT,Vesper HW,Phinney KW,et al. Vitamin D status as an international issue:national surveys and the problem of standardization[J]. Scand J Clin Lab Invest Suppl,2012,243:32-40.
[19] Crandall C. Vitamin A intake and osteoporosis:a clinical review[J]. J Womens Health(Larchmt),2004,13:939-953.
[20] Feskanich D,Singh V,Willett WC,et al. Vitamin A intake and hip fractures among postmenopausal women[J]. JAMA 2002,287:47-54.
[21] Hamidi MS,Cheung AM. Vitamin K and musculoskeletal health in postmenopausal women[J]. Mol Nutr Food Res,2014,58:1647-1657.
[22] Kanellakis S,Moschonis G,Tenta R,et al. Changes in parameters of bone metabolism in postmenopausal women following a 12-month intervention period using dairy products enriched with calcium,vitamin D,and phylloquinone(vitamin K(1))or menaquinone-7(vitamin K(2)):the Postmenopausal Health Study II[J]. Calcif Tissue Int,2012,90:251-262.
[23] Chin KY,Ima-Nirwana S. The effects ofα-tocopherol on bone:a double-edged sword?[J]. Nutrients,2014,6:1424-1441.
[24] Schleicher RL,Carroll MD,Ford ES,et al. Serum vitamin C and the prevalence of vitamin C deficiency in the United States:2003-2004 National Health and Nutrition Examination Survey(NHANES)[J]. Am J Clin Nutr,2009,90:1252-1263.
[25] Simon JA,Hudes ES. Relation of ascorbic acid to bone mineral density and self-reported fractures among US adults[J]. Am J Epidemiol 2001,154:427-433.
[26] Sahni S,Hannan MT,Gagnon D,et al. Protective effect of total and supplemental vitamin C intake on the risk of hip fracture-a 17-year follow-up from the Framingham Osteoporosis Study[J]. Osteoporos Int,2009,20:1853-1861.
[27] Munger RG,Cerhan JR,Chiu BC. Prospective study of dietary protein intake and risk of hip fracture in postmenopausal women[J]. Am J Clin Nutr,1999,69:147-152.
[28] Langsetmo L, Barr SI, Berger C, et al. Ca Mos Research Group. Associations of protein intake and protein source with bone mineral density and fracture risk:a population-based cohort study[J]. J Nutr Health Aging,2015,19:861-868.
[29] Sahni S,Cupples LA,McLean RR,et al. Protective effect of high protein and calcium intake on the risk of hip fracture in the Framingham offspring cohort[J]. J Bone Miner Res,2010,25:2770-2776.
[30] Institute of Medicine,Panel on Macronutrients and Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Dietary reference intakes for energy,carbohydrate,fiber,fat,fatty acids,cholesterol, protein, and amino acids(macronutrients)[M]. Washington D. C:National Academies Press,2005:769-879.
[31] Shen CL,Chyu MC. Tea flavonoids for bone health:from animals to humans[J]. J Investig Med,2016,64:1151-1157.
[32]杨克敌.微量元素与健康[M].北京:科学出版社,2003:242.
[33] Haguenauer D,Welch V,Shea B,et al. Fluoride for the treatment of postmenopausal osteoporotic fractures:a meta-analysis[J]. Osteoporos Int, 2000, 11:727-738.
[34] Querido W,Rossi AL,Farina M. The effects of strontium on bone mineral:a review on current knowledge and microanalytical approaches[J]. Micron, 2016,80:122-134.
[35] Institute of Medicine. Dietary Reference Intakes for vitamin A,vitamin K,arsenic,boron,chromium,copper,iodine,iron,manganese,molybdenum,nickel,silicon,vanadium,and zinc[M]. Washington D. C:National Academies Press,2001.
[2] Heaney RP. Methods in nutrition science:the bone remodeling transient:interpreting interventions involving bone-related nutrients[J]. Nutr Rev, 2001, 59:327-334.
[3] Bailey RL,Gahche JJ,Lentino CV,et al. Dietary supplement use in the United States[J]. J Nutr,2011,141:261-266.
[4] Marques-Vidal P,Pecoud A,Hayoz D,et al. Prevalence and characteristics of vitamin or dietary supplement users in Lausanne, Switzerland:the Co Laus study[J]. Eur J Clin Nutr,2009,63:273-281.
[5] Rovira MA,Grau M,Castaner O,et al. REGICOR Investigators Dietary supplement use and health-related behaviors in a Mediterranean population[J]. J Nutr Educ Behav,2013,45:386-391.
[6] Hurley DL,Binkley N,Camacho PM,et al. The use of vitamins and minerals in skeletal health:American Association of Clinical Endocrinologists and the American College of Endocrinology(AACE/ACE)osition statement[J]. Endocr Pract,2018,24:915-924.
[7] Kovacs CS. Calcium and bone metabolism disorders during pregnancy and lactation[J]. Endocrinol Metab Clin N Am,2011,40:795-826.
[8] Goulding A,Rockell JE,Black RE,et al. Children who avoid drinking cow's milk are at increased risk for prepubertal bone fractures[J]. J Am Diet Assoc,2004,104:250-253.
[9] Matkovic V,Goel PK,Badenhop-Stevens NE,et al.Calcium supplementation and bone mineral density in females from childhood to young adulthood:a randomized controlled trial[J]. Am J Clin Nutr,2005,81:175-188.
[10] Avenell A,Mak JC,O'Connell D. Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men[J]. Cochrane Database Syst Rev,2014,14:CD000227.
[11] Weaver CM,Alexander DD,Boushey CJ,et al. Calcium plus vitamin D supplementation and risk of fractures:an updated meta-analysis from the National Osteoporosis Foundation[J]. Osteoporos Int,2016,27:367-376.
[12] Calvo MS,Uribarri J. Public health impact of dietary phosphorus excess on bone and cardiovascular health in the general population[J]. Am J Clin Nutr,2013,98:6-15.
[13] Lee AW,Cho SS. Association between phosphorus intake and bone health in the NHANES population[J].Nutr J,2015,14:28.
[14] Rosanoff A,Weaver CM,Rude RK. Suboptimal magnesium status in the United States:are the health consequences underestimated?[J]. Nutr Rev, 2012,70:153-164.
[15] Orchard TS,Larson JC,Alghothani N,et al. Magne-sium intake,bone mineral density,and fractures:results from the Women's Health Initiative Observational Study[J]. Am J Clin Nutr,2014,99:926-933.
[16] Carbone L,Johnson KC,Huang Y,et al. Sodium intake and osteoporosis. Findings from the Women's Health Initiative[J]. J Clin Endocrinol Metab,2016,101:1414-1421.
[17] Carmel AS,Shieh A,Bang H,et al. 2011 The 25(OH)D level needed to maintain a favorable bisphosphonate response is> 33 ng/m L[J]. J Bone Miner Res,2012,23:2479-2487.
[18] Sempos CT,Vesper HW,Phinney KW,et al. Vitamin D status as an international issue:national surveys and the problem of standardization[J]. Scand J Clin Lab Invest Suppl,2012,243:32-40.
[19] Crandall C. Vitamin A intake and osteoporosis:a clinical review[J]. J Womens Health(Larchmt),2004,13:939-953.
[20] Feskanich D,Singh V,Willett WC,et al. Vitamin A intake and hip fractures among postmenopausal women[J]. JAMA 2002,287:47-54.
[21] Hamidi MS,Cheung AM. Vitamin K and musculoskeletal health in postmenopausal women[J]. Mol Nutr Food Res,2014,58:1647-1657.
[22] Kanellakis S,Moschonis G,Tenta R,et al. Changes in parameters of bone metabolism in postmenopausal women following a 12-month intervention period using dairy products enriched with calcium,vitamin D,and phylloquinone(vitamin K(1))or menaquinone-7(vitamin K(2)):the Postmenopausal Health Study II[J]. Calcif Tissue Int,2012,90:251-262.
[23] Chin KY,Ima-Nirwana S. The effects ofα-tocopherol on bone:a double-edged sword?[J]. Nutrients,2014,6:1424-1441.
[24] Schleicher RL,Carroll MD,Ford ES,et al. Serum vitamin C and the prevalence of vitamin C deficiency in the United States:2003-2004 National Health and Nutrition Examination Survey(NHANES)[J]. Am J Clin Nutr,2009,90:1252-1263.
[25] Simon JA,Hudes ES. Relation of ascorbic acid to bone mineral density and self-reported fractures among US adults[J]. Am J Epidemiol 2001,154:427-433.
[26] Sahni S,Hannan MT,Gagnon D,et al. Protective effect of total and supplemental vitamin C intake on the risk of hip fracture-a 17-year follow-up from the Framingham Osteoporosis Study[J]. Osteoporos Int,2009,20:1853-1861.
[27] Munger RG,Cerhan JR,Chiu BC. Prospective study of dietary protein intake and risk of hip fracture in postmenopausal women[J]. Am J Clin Nutr,1999,69:147-152.
[28] Langsetmo L, Barr SI, Berger C, et al. Ca Mos Research Group. Associations of protein intake and protein source with bone mineral density and fracture risk:a population-based cohort study[J]. J Nutr Health Aging,2015,19:861-868.
[29] Sahni S,Cupples LA,McLean RR,et al. Protective effect of high protein and calcium intake on the risk of hip fracture in the Framingham offspring cohort[J]. J Bone Miner Res,2010,25:2770-2776.
[30] Institute of Medicine,Panel on Macronutrients and Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Dietary reference intakes for energy,carbohydrate,fiber,fat,fatty acids,cholesterol, protein, and amino acids(macronutrients)[M]. Washington D. C:National Academies Press,2005:769-879.
[31] Shen CL,Chyu MC. Tea flavonoids for bone health:from animals to humans[J]. J Investig Med,2016,64:1151-1157.
[32]杨克敌.微量元素与健康[M].北京:科学出版社,2003:242.
[33] Haguenauer D,Welch V,Shea B,et al. Fluoride for the treatment of postmenopausal osteoporotic fractures:a meta-analysis[J]. Osteoporos Int, 2000, 11:727-738.
[34] Querido W,Rossi AL,Farina M. The effects of strontium on bone mineral:a review on current knowledge and microanalytical approaches[J]. Micron, 2016,80:122-134.
[35] Institute of Medicine. Dietary Reference Intakes for vitamin A,vitamin K,arsenic,boron,chromium,copper,iodine,iron,manganese,molybdenum,nickel,silicon,vanadium,and zinc[M]. Washington D. C:National Academies Press,2001.