摘要
药物共晶作为近年来晶型药物研究中新的方向,正在受到广泛关注。共晶研究对于改善药物的溶解度、生物利用度及物理化学稳定性具有科学意义。该文从心脑血管疾病治疗药物的角度出发,针对心力衰竭、高血压、冠心病、心律失常、脑卒中五类发病率较高的心脑血管疾病,选取近年来具有代表性的10余种药物共晶研究的最新成果进行综述,为后续相关药物的共晶研究提供参考依据。
The pharmaceutical co-crystal has attracted a lot of attention in recent years as a new direction in the research of polymorphism drugs. The research on pharmaceutical co-crystal has scientific significance for improving the solubility,bioavailability and physical or chemical stability of drugs. In this paper,from the perspective of drugs for the treatment of cardiovascular diseases( including five major types: heart failure,hypertension,coronary heart disease and arrhythmia,stroke),the latest research results of pharmaceutical co-crystal reported in recent years are reviewed,hope to provide reference for the follow-up research and promote the development of pharmaceutical co-crystal in China.
引文
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