经皮冠状动脉介入治疗对冠心病血瘀证病人证候积分的影响
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摘要
目的通过观察经皮冠状动脉介入(PCI)治疗对冠心病血瘀证病人证候积分的影响,探索其对血瘀证的改善作用。方法观察病人年龄、性别、冠状动脉病变支数、病变狭窄程度等因素对PCI治疗前后血瘀证积分的影响;观察心电图的变化与血瘀证积分的关系;观察冠心病血瘀证病人PCI治疗前后血瘀证积分的差异。结果冠心病病人年龄越大、冠状动脉病变支数越多、狭窄程度越严重,血瘀证积分越高;有临床症状或心电图异常者,血瘀证积分越高;PCI治疗后能够缓解病人临床症状,降低狭窄程度,减少病变支数,改善异常的心电图。结论 PCI治疗后能迅速改善冠心病血瘀证病人的临床症状及异常的心电图,降低血瘀证积分。
Objective To explore the influence of percutaneous coronary intervention(PCI)on the syndromes in patients with coronary heart disease(CHD)and blood stasis syndrome,and to investigate its improvement in blood stasis syndrome.Methods The influence of factors such as age,sex,number of coronary artery lesions and degree of lesion stenosis on blood stasis syndrome were observed before and after PCI.The relationship between electrocardiogram(ECG)changes and the blood stasis syndrome scores was analyzed.The difference of blood stasis syndrome scores were observed in patients with CHD and blood stasis syndrome before and after PCI.Results The syndrome score was positively correlated with age,the number of coronary artery lesions and the degree of stenosis.Patients with clinical symptoms or abnormal electrocardiogram had the higher the score of blood stasis syndrome.PCI could alleviate the patient's clinical symptoms,reduce the degree of stenosis,reduce the number of lesions,and improve the abnormal electrocardiogram.Conclusion PCI can improve the clinical symptoms and abnormal electrocardiogram in patients with CHD and blood stasis syndrome rapidly,and reduce the score of blood stasis syndrome.
Objective To explore the influence of percutaneous coronary intervention(PCI)on the syndromes in patients with coronary heart disease(CHD)and blood stasis syndrome,and to investigate its improvement in blood stasis syndrome.Methods The influence of factors such as age,sex,number of coronary artery lesions and degree of lesion stenosis on blood stasis syndrome were observed before and after PCI.The relationship between electrocardiogram(ECG)changes and the blood stasis syndrome scores was analyzed.The difference of blood stasis syndrome scores were observed in patients with CHD and blood stasis syndrome before and after PCI.Results The syndrome score was positively correlated with age,the number of coronary artery lesions and the degree of stenosis.Patients with clinical symptoms or abnormal electrocardiogram had the higher the score of blood stasis syndrome.PCI could alleviate the patient's clinical symptoms,reduce the degree of stenosis,reduce the number of lesions,and improve the abnormal electrocardiogram.Conclusion PCI can improve the clinical symptoms and abnormal electrocardiogram in patients with CHD and blood stasis syndrome rapidly,and reduce the score of blood stasis syndrome.
引文
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[18]薛梅,陈可翼,马晓娟,等.血府逐瘀口服液对冠心病血瘀证患者血液流变的影响及其与人类血小板抗原3基因多态性的相关性[J].中西医结合学报,2008,6(11):1129-1135.
[19]BI Y F,MAO J Y.Clinical epidemiology survey of the traditional Chinese medicine etiology and syndrome differentiation of coronary artery disease:study protocol of a multicenter trial[J].Journal of Chinese Integrative Medicine,2012,10(6):619-626.
[2]王权明,彭云波,覃永旗.冠心病猝死与心绞痛的症状及心电图规律分析[J].中国医药导刊,2012,14(10):906-907.
[3]陈剑.丹参酮ⅡA磺酸钠注射液佐治冠心病稳定型心绞痛的疗效观察[J].临床医学,2014,22(6):48-49.
[4]杜毅,杨关林,陈旭,等.基于文献的冠心病中医证候与冠脉造影结果的研究[J].辽宁中医杂志,2012,39(6):1034-1035.
[5]孙建春,宫剑滨,潘涛,等.IL-6、hs-CRP与冠心病中医证型及冠脉病变程度的相关性研究[J].辽宁中医杂志,2011,38(2):299-300.
[6]苏鑫,高铸烨,张庆翔,等.未经血运重建的冠心病Gensini评分与血瘀证的相关性研究[J].中西医结合心脑血管病杂志,2013,11(2):129-130.
[7]刘红旭,王镇裕,尚菊菊.冠心病病人冠状动脉造影结果与血瘀证相关性研究[J].中西医结合心脑血管病杂志,2007,5(3):189-190.
[8]刘红旭,王振裕,彭伟,等.113例冠状动脉造影病人中医证候与造影特点分析[J].中日友好医院学报,2006,20(1):35-37.
[9]ONAT A,CAN G,HERGENC G,et al.Coronary disease risk prediction algorithm warranting incorporation of C-reactive protein in Turkish adults,manifesting sex difference[J].Nutr Metab Cardiovasc Dis,2011,2(9):21-31.
[10]BHATTI S,HAKEEM A,YOUSUF M A,et al.Diagnostic performance of computed tomography angiography for differentiating ischemic vs non-ischemic cardiomyopathy[J].J Nucl Cardiol,2011,2(17):22.
[11]GARCIA-GARCIA H M,GOGAS B D,SERRUYS P W,et al.IVUS-based imaging modalities for tissue characterization:similarities and differences[J].Int J Cardiovasc Imaging,2011,2(17):213-229.
[12]中华医学会心血管病学分会,中华心血管病杂志编辑委员会.不稳定性心绞痛和非ST段抬高心肌梗死诊断与治疗指南[J].中华心血管病杂志,2012,40(5):353-367.
[13]胡丽娜,陈小光,吴焕林,等.冠心病中医证型与冠状动脉狭窄程度的相关性研究[J].中国医药指南,2015,13(24):5-7.
[14]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国中医药科技出版社,2002:68-73.
[15]靳宏光,齐锋,王义强,等.冠心病痰瘀证客观指标的临床研究[J].世界科学技术---中医药现代化,2013,15(5):1032-1036.
[16]刘燕平,黄岑汉,贾微,等.冠心病血瘀证研究述要[J].河南中医,2012,32(3):314-316.
[17]周景想,纪文岩,吉中强,等.冠心病心绞痛血瘀证证候特点及相关影响因素分析[J].中医学报,2015,30(1):123-124.
[18]薛梅,陈可翼,马晓娟,等.血府逐瘀口服液对冠心病血瘀证患者血液流变的影响及其与人类血小板抗原3基因多态性的相关性[J].中西医结合学报,2008,6(11):1129-1135.
[19]BI Y F,MAO J Y.Clinical epidemiology survey of the traditional Chinese medicine etiology and syndrome differentiation of coronary artery disease:study protocol of a multicenter trial[J].Journal of Chinese Integrative Medicine,2012,10(6):619-626.