TPO抗体升高类风湿性关节炎患者的中医辨证分型
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摘要
目的:探讨TPO抗体升高类风湿性关节炎患者中医证型分布及甲状腺功能情况。方法:结合相关文献制定病例报告表,并记录中医证候,运用聚类分析统计学方法对40例TPO抗体升高类风湿性关节炎患者的中医证候进行辨证分型。结果:TPO抗体升高类风湿性关节炎患者基本证候为:寒湿阻络证,湿热痹阻证,气血两虚证和肝肾阴虚证;甲状腺功能异常的比例为50.0%;中医证候符合肝郁气滞证的比例为32.5%。结论:TPO抗体升高类风湿性关节炎患者中医辨证分型初步分为:寒湿阻络证,湿热痹阻证,气血两虚证和肝肾阴虚证。中医证候符合肝郁气滞证的比例较高。
Objective:To investigate the distribution of TCM syndromes and thyroid function in patients with rheumatoid arthritis(RA) with elevated TPO antibody.Methods:Considering the diagnostic points of TCM syndromes,a case report form was drawn up,TCM syndromes were recorded,and the TCM syndromes of 40 patients with rheumatoid arthritis with elevated TPO antibody were classified by cluster analysis.Results:The basic syndromes of 40 patients with rheumatoid arthritis with elevated TPO antibody were cold-dampness obstructing meridians syndrome,damp-heat obstruction syndrome,qi-blood deficiency syndrome,liver-kidney yin deficiency syndrome,liver depression and qi stagnation syndrome.The proportion of abnormal thyroid function was 50.0%,and the proportion of TCM syndromes conforming to "liver depression and qi stagnation syndrome" was 32.5%.Conclusion:TCM syndrome differentiation of rheumatoid arthritis patients with elevated TPO antibody can be divided into cold-dampness obstructing meridians syndrome,damp-heat obstruction syndrome,qi-blood deficiency syndrome,liver-kidney yin deficiency syndrome,liver depression and qi stagnation syndrome.The proportion of TCM syndromes conforming to "liver depression and qi stagnation syndrome" is higher.
Objective:To investigate the distribution of TCM syndromes and thyroid function in patients with rheumatoid arthritis(RA) with elevated TPO antibody.Methods:Considering the diagnostic points of TCM syndromes,a case report form was drawn up,TCM syndromes were recorded,and the TCM syndromes of 40 patients with rheumatoid arthritis with elevated TPO antibody were classified by cluster analysis.Results:The basic syndromes of 40 patients with rheumatoid arthritis with elevated TPO antibody were cold-dampness obstructing meridians syndrome,damp-heat obstruction syndrome,qi-blood deficiency syndrome,liver-kidney yin deficiency syndrome,liver depression and qi stagnation syndrome.The proportion of abnormal thyroid function was 50.0%,and the proportion of TCM syndromes conforming to "liver depression and qi stagnation syndrome" was 32.5%.Conclusion:TCM syndrome differentiation of rheumatoid arthritis patients with elevated TPO antibody can be divided into cold-dampness obstructing meridians syndrome,damp-heat obstruction syndrome,qi-blood deficiency syndrome,liver-kidney yin deficiency syndrome,liver depression and qi stagnation syndrome.The proportion of TCM syndromes conforming to "liver depression and qi stagnation syndrome" is higher.
引文
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[10] 许平英,娄玉钤,杨亚飞,等.类风湿性关节炎中医辨证分型研究概况[J].风湿病与关节炎,2015,4(4):72-76.
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[13] 陈学进.数据挖掘中聚类分析的研究[J].计算机技术与发展,2006,16(9):45-49.
[2] SHIROKY J B,COHEN M,BAL LACHEY M L,et al.Thyroid dysfunction in rheumatoid arthritis:a controlled prospective survey[J].Ann Rheum Dis,1993,52(6):454-456.
[3] ATZENI F,DORIA A,GHIRARDELLO A,et a1.Organ-specific autoantibodies in patients with rheumatoid arthritis treated with adalimumab:a prospective long-term follow-up[J].Autoimmunity,2008,41(1):87.
[4] PAN X J,GU Z,SHAN.Increased risk of thyroid autoimmunity in rheumatoid arthritis:a systematic review and meta-analysis[J].Endocrine,2015,50(1):79-86.
[5] ROLDAN JC,AMAYA AJ,CASTELLANOS H J,et al.Autoimmune thyroid disease in rheumatoid arthritis:a global perspective[J].Arthritis,2012,55(7):557-562.
[6] 王晓东.类风湿性关节炎患者甲状腺功能异常临床分析[J].中华实用诊断与治疗杂志,2008,22(9):664-666.
[7] 施春花,王友莲,尚可,等.类风湿性关节炎甲状腺状况的临床研究[J].江西医药,2011,46 (5):441-443.
[8] 宋芹,毛玉景,郭向华,等.结缔组织病与甲状腺疾病的相关性[J].中华临床免疫和变态反应杂志,2014,8(1):52-55.
[9] 邵勤,王婷,吴斌.类风湿性关节炎甲状腺功能状况分析[J].重庆医学,2017,46(3):331-332.
[10] 许平英,娄玉钤,杨亚飞,等.类风湿性关节炎中医辨证分型研究概况[J].风湿病与关节炎,2015,4(4):72-76.
[11] 郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:52.
[12] 韩家炜.数据挖掘:概念与技术[M].北京:机械工业出版社,2000:196-197.
[13] 陈学进.数据挖掘中聚类分析的研究[J].计算机技术与发展,2006,16(9):45-49.