中医药调控H IF-1治疗湿性老年性黄斑变性的探讨
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摘要
分析近年来相关文献,就中医药调控缺氧诱导因子1(hypoxia inducible factor-1,HIF-1)防治湿性年龄相关性黄斑变性(wet age-related macular degeneration,WAMD)的机理进行探讨。
Through analyzing the literature in the recent yeats, the mechanism of TCM regulating hypoxia inducible factor-1(HIF-1) in the prevention and treatment for wet age-related macular degeneration(WAMD) is discussed.
Through analyzing the literature in the recent yeats, the mechanism of TCM regulating hypoxia inducible factor-1(HIF-1) in the prevention and treatment for wet age-related macular degeneration(WAMD) is discussed.
引文
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[5]苏映雪,姚向超.雷公藤甲素防治脉络膜新生血管形成的研究进展[J].临床药物治疗杂志,2016,14(6):6-10.
[6]Mehta S.Age-related macular degeneration[J].Prim Care,2015:42(3):377-391.
[7]Cackett P,Wong TY,Aung T,et al.Smoking,cardiovascular risk factors and age-related macular degeneration in Asians:the Singapore Malay Eye Study[J].Am J Ophthalmol,2008,146(6):960-967.
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[13]Kwak N,OKamoto N,Wood JM,et al.VEGF is major stimulator in model of choroidal neovascularization[J].invest ophthalmol Vis Sci,2000:41(10):3158-3164.
[14]Grunwald JE,Metelitssina TI,Du Pont JC,et al.Reduced foveolar choroidal blood flow in eyes with increasing AMD severity.Invest Ophthalmol Vis Sci,2005,46(7):1033-1038.
[15]Huang LE,Arany Z,Livingston DM,et al.Activation of hypoxia-inducible transcription factor depends primarily upon radox-sensitive stabilization of its alpha subunit[J].J Biol Chem.1996,271(50):32253-32259.
[16]Vincent KA,Shyu KG,Luo Y,et al.Angiogenesis is in duced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1 alpha/VP16 hybrid transcription factor[J].Circulation,2000,31(18):2255-2261.
[17]Von marschall Z,Cramer T,Hocker M,et al.Dual mechanism of vascular endothelial growth factor upregulation by hypoxia in human hepatocellular carcinoma[J].Gut,2001;48(1):87-96.
[18]Gerber HP,Condorelli F,Park J,et al.Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes.Flt-1,but not FIK-1/KDR,is up-regulated by hypoxia[J].J Biol Chem,1997,272(38):23659-23667.
[19]张励,唐由之.年龄相关性黄斑变性的研究进展[J].中国中医眼科杂志,2005,15(3):177-179.
[20]李学晶,唐由之.年龄相关性黄斑变性的中医认识[J].中国中医眼科杂志,2008,18(4):240-242.
[21]周尚昆,钟舒阳,王慧娟,等.唐由之治疗湿性老年黄斑变性经验[J].辽宁中医杂志,2011,54(1):34-35.
[22]梁凤鸣,王莉,雷晓琴.王明芳教授治疗老年性黄斑变性的经验[J].成都中医药大学学报,1997,40(2):4-5.
[23]姚大莉.王明芳用内眼辨证治疗老年性黄斑变性[J].四川中医,2002,31(6):7-8.
[24]魏伟,范海霞.“健脾化浊方”治疗湿性老年黄斑变性的临床研究[J].江苏中医药,2011,56(10):26-27.
[25]高娜,亢泽锋,刘彦江,等.加减驻景方含药血清对二氧化钴诱导的ARPE-19细胞增殖的影响[J].青海医学院学报,2014,35(4):232-237.
[26]马珊,王明芳.凉血活血药物对氧诱导小鼠视网膜新生血管实验中HIF-1和NF-κB的影响[J].昆明医科大学学报,2012,33(10):19-22.
[2]田蔓男,张月梅,李丽,等.老年性黄斑变性的流行病学调查[J].兰州大学学报:医学版,2005,31(2):70-74.
[3]王玉国,高宇.年龄相关性黄斑变性的研究进展[J].航空航天医学杂志,2007,18(1):57-59.
[4]Green WR.Histopathology of age-related macular degeneration[J].Mol Vis,1999,3(5):27-36.
[5]苏映雪,姚向超.雷公藤甲素防治脉络膜新生血管形成的研究进展[J].临床药物治疗杂志,2016,14(6):6-10.
[6]Mehta S.Age-related macular degeneration[J].Prim Care,2015:42(3):377-391.
[7]Cackett P,Wong TY,Aung T,et al.Smoking,cardiovascular risk factors and age-related macular degeneration in Asians:the Singapore Malay Eye Study[J].Am J Ophthalmol,2008,146(6):960-967.
[8]魏敏,雷春涛,陈辉,等.四川省视力残疾状况调查分析[J].国际眼科杂志,2007,7(6):1652-1654.
[9]王肯堂.证治准绳[M].上海:上海科学技术出版社,1959:486.
[10]傅仁宇.审视瑶函[M].上海:上海人民出版社,1977:178.
[11]陈达夫.中医眼科六经法要[M].成都:四川人民出版社,1978:25.
[12]Bird AC,Bressler NM,Bressler SB,et al.An international classification and grading system for age-related maculopathy and age-related macular degeneration[J].Surv Ophthalmol,1995,399(5):367-374.
[13]Kwak N,OKamoto N,Wood JM,et al.VEGF is major stimulator in model of choroidal neovascularization[J].invest ophthalmol Vis Sci,2000:41(10):3158-3164.
[14]Grunwald JE,Metelitssina TI,Du Pont JC,et al.Reduced foveolar choroidal blood flow in eyes with increasing AMD severity.Invest Ophthalmol Vis Sci,2005,46(7):1033-1038.
[15]Huang LE,Arany Z,Livingston DM,et al.Activation of hypoxia-inducible transcription factor depends primarily upon radox-sensitive stabilization of its alpha subunit[J].J Biol Chem.1996,271(50):32253-32259.
[16]Vincent KA,Shyu KG,Luo Y,et al.Angiogenesis is in duced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1 alpha/VP16 hybrid transcription factor[J].Circulation,2000,31(18):2255-2261.
[17]Von marschall Z,Cramer T,Hocker M,et al.Dual mechanism of vascular endothelial growth factor upregulation by hypoxia in human hepatocellular carcinoma[J].Gut,2001;48(1):87-96.
[18]Gerber HP,Condorelli F,Park J,et al.Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes.Flt-1,but not FIK-1/KDR,is up-regulated by hypoxia[J].J Biol Chem,1997,272(38):23659-23667.
[19]张励,唐由之.年龄相关性黄斑变性的研究进展[J].中国中医眼科杂志,2005,15(3):177-179.
[20]李学晶,唐由之.年龄相关性黄斑变性的中医认识[J].中国中医眼科杂志,2008,18(4):240-242.
[21]周尚昆,钟舒阳,王慧娟,等.唐由之治疗湿性老年黄斑变性经验[J].辽宁中医杂志,2011,54(1):34-35.
[22]梁凤鸣,王莉,雷晓琴.王明芳教授治疗老年性黄斑变性的经验[J].成都中医药大学学报,1997,40(2):4-5.
[23]姚大莉.王明芳用内眼辨证治疗老年性黄斑变性[J].四川中医,2002,31(6):7-8.
[24]魏伟,范海霞.“健脾化浊方”治疗湿性老年黄斑变性的临床研究[J].江苏中医药,2011,56(10):26-27.
[25]高娜,亢泽锋,刘彦江,等.加减驻景方含药血清对二氧化钴诱导的ARPE-19细胞增殖的影响[J].青海医学院学报,2014,35(4):232-237.
[26]马珊,王明芳.凉血活血药物对氧诱导小鼠视网膜新生血管实验中HIF-1和NF-κB的影响[J].昆明医科大学学报,2012,33(10):19-22.