Ca~(2+)交联处理对聚乙烯醇/海藻酸钠水凝胶吸水保水性能和溶蚀率的影响
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摘要
为提高聚乙烯醇(PVA)水凝胶凝胶分数、吸水率、保水率和降低其溶蚀率,采用PVA/海藻酸钠(SA)循环冻融成型方法,并结合钙离子交联处理制备互穿网络水凝胶,探究了Ca~(2+)交联处理对PVA/SA复合水凝胶吸水保水性能和溶蚀率的影响规律。结果表明:PVA7SA3、0.05mol/L、4h条件下溶蚀率最小(2.33%),凝胶分数最高(92.6%);PVA7SA3、0.01mol/L、2h条件下吸水最高(350%),凝胶分数较低(85.9%),但均与PVA对照组水凝胶存在统计学差异。PVA8SA2在1h内保水性能最好,0.05mol/L浓度下处理4h保水率可达60%。结果表明,增大Ca~(2+)交联浓度和延长交联处理时间对提高凝胶分数有积极影响,水凝胶溶蚀率和吸水率变化均与凝胶分数呈负相关。
To improve the gel fraction,water absorption rate,water retention rate and corrosion ratio of polyvinyl alcohol(PVA)hydrogel,PVA/sodium alginate(SA)cyclic freeze-thaw forming method combined with calcium ion crosslinking treatment is used to prepare interpenetrating network hydrogel.The effect of Ca~(2+)cross-linking treatment on the water-holding performance and corrosion ratio of PVA/SA composite hydrogel is investigated.The results show that the corrosion ratio is the lowest(2.33%)and the gel fraction is highest(92.6%)under PVA7SA3,0.05mol/L,4h,while the water absorption is the highest(350%)and the gel fraction is lower(85.9%)in the case of PVA7SA3,0.01mol/L,2h,which are all statistically different from the PVA control hydrogel.Besides,PVA8SA2 has the best water retention performance within 1hand its water retention rate can reach 60%after 4htreatment at 0.05mol/L concentration.Conclusions are as follows:increasing the Ca~(2+)cross-linking concentration and prolonging the cross-linking treatment time have a positive effect on enhancing the gel fraction;the hydrogel corrosion ratio and water absorption change are negatively correlated with the gel fraction.
To improve the gel fraction,water absorption rate,water retention rate and corrosion ratio of polyvinyl alcohol(PVA)hydrogel,PVA/sodium alginate(SA)cyclic freeze-thaw forming method combined with calcium ion crosslinking treatment is used to prepare interpenetrating network hydrogel.The effect of Ca~(2+)cross-linking treatment on the water-holding performance and corrosion ratio of PVA/SA composite hydrogel is investigated.The results show that the corrosion ratio is the lowest(2.33%)and the gel fraction is highest(92.6%)under PVA7SA3,0.05mol/L,4h,while the water absorption is the highest(350%)and the gel fraction is lower(85.9%)in the case of PVA7SA3,0.01mol/L,2h,which are all statistically different from the PVA control hydrogel.Besides,PVA8SA2 has the best water retention performance within 1hand its water retention rate can reach 60%after 4htreatment at 0.05mol/L concentration.Conclusions are as follows:increasing the Ca~(2+)cross-linking concentration and prolonging the cross-linking treatment time have a positive effect on enhancing the gel fraction;the hydrogel corrosion ratio and water absorption change are negatively correlated with the gel fraction.
引文
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[2]TERCERO J E,NAMIN S,LAHIRI D,et al.Effect of carbon nanotube and aluminum oxide addition on plasma-sprayed hydroxyapatite coating’s mechanical properties and biocompatibility[J].Materials Science and Engineering C,2009,29(7):2195-2202.
[3]YANG J M,YANG J H,TSOU S C,et al.Cell proliferation on PVA/sodium alginate and PVA/poly(γ-glutamic acid)electrospun fiber[J].Materials Science and Engineering C,2016,66:170-177.
[4]LIU J,LIU G,LIU W.Preparation of water-solubleβ-cyclodextrin/poly(acrylic-acid)/graphene oxide nanocomposites as new adsorbents to remove cationic dyes from aqueous solutions[J].Chemical Engineering Journal,2014,257:299-308.
[5]SAKAI S,TSUMURA M,INOUE M,et al.Polyvinyl alcohol-based hydrogel dressing gellable on-wound via a co-enzymatic reaction triggered by glucose in the wound exudate[J].Journal of Materials Chemistry B,2013,38(1):5067-5075.
[6]SEGAL H C,HUNT B J,GILDING K.The effects of alginate and non-alginate wound dressings on blood coagulation and platelet activation[J].Journal of Biomaterials Applications,1998,12(3):249-257.
[7]SAMPSON B,ROWE A.Sequential changes in trace metal,metallothionein and calmodulin concentrations in healing skin wounds[J].Journal of Anatomy,1999,195(3):375-378.
[8]王清华,苏秋妹.湿性敷料治疗皮肤Ⅱ度烧伤的比较[J].中国组织工程研究,2013,17(8):1513-1520.WANG Qinghua,SU Qiumei.Synthetic dressing for the treatment of skin[J].Chinese Journal of Tissue Engineering Research,2013,17(8):1513-1520.(in Chinese)
[9]廉哲,胡安杨,张毅,等.聚乙烯醇/海藻酸钠互穿网络水凝胶结构与性能研究[J].高分子通报,2014(2):156-161.LIAN Zhe,HU Anyang,ZHANG Yi,et al.Structure and property of polyvinyl alcohol/sodium alginate IPNhydrogel[J].Polymer Bulletin,2014(2):156-161.(in Chinese)
[10]XIE L,JIANG M,DONG X,et al.Controlled mechanical and swelling properties of poly(vinyl alcohol)/sodium alginate blend hydrogels prepared by freezethaw followed by Ca2+crosslinking[J].Journal of Applied Polymer Science,2012,124(1):823-831.
[11]JIANG X,XIANG N,ZHANG H,et al.Preparation and characterization of poly(vinyl alcohol)/sodium alginate hydrogel with high toughness and electric conductivity[J].Carbohydrate Polymers,2018,186:377-383.
[12]RADHAKUMARY C,ANTONTY M,SREENIVA-SAN K.Drug loaded thermoresponsive and cytocompatible chitosan based hydrogel as a potential wound dressing[J].Carbohydrate Polymers,2011,83(2):705-713.
[13]VARAPRASAD K,MOHAN Y M,RAVINDRA S,et al.Hydrogel-silver nanoparticle composites:a new generation of antimicrobials[J].Journal of Applied Polymer Science,2010,115(2):1199-1207.
[14]THATIPARTI T R,KANO A,MARUYAMA A,et al.Novel silver-loaded semi-interpenetrating polymer network gel films with antibacterial activity[J].Journal of Polymer Science Part A:Polymer Chemistry,2009,47(19):4950-4962.
[15]JIA W,BEATTY M W,REINHARDT R A,et al.Nickel release from orthodontic arch wires and cellular immune response to various nickel concentrations[J].Journal of Biomedical Materials Research,1999,48(4):488-499.
[16]LEE J E,PARK J C,LEE K H,et al.An infectionpreventing bilayered collagen membrane containing antibiotic-loaded hyaluronan microparticles:physical and biological properties[J].Artificial Organs,2015,26(7):636-646.
[17]章汝平,丁马太.海藻酸钠/聚乙烯醇共混膜的制备及表征[J].功能材料,2009,40(2):295-297.ZHANG Ruping,DING Matai.Preparation,properties and characterization of the blend film of sodium alginate and polyvinyl alcohol[J].Function Materials,2009,40(2):295-297.(in Chinese)
[18]卓萍,吴文辉,郭炜.离子强度对P(HEMA-co-MMA)水凝胶溶胀性能及水的状态的影响[J].功能高分子学报,2005,18(2):198-203.ZHUO Ping,WU Wenhui,GUO Wei.Effect of ionic strength on the swelling behavior and the state of water of P(HEMA-co-MMA)hydrogel[J].Journal of Functional Polymers,2005,18(2):198-203.(in Chinese)
[19]CLARK A H,ROSS-MURPHY S B.Structural and mechanical properties of biopolymer gels[M].Berlin:Springer-Verlag.1987:322-338.
[20]REES D A.Polysaccharide shapes and their interactions-some recent advances[J].Pure and Applied Chemistry,2009,53(1):1-14.
[21]李文波,薛锋,程镕时.化学交联聚乙烯醇(PVA)水凝胶的合成、表征及溶胀特性[J].高分子学报,2006(5):671-675.LI Wenbo,XUE Feng,CHENG Rongshi.Synthesis,characterization and swelling of a chemically crosslinked PVA hydrogel[J].Acta Polymerica Sinica,2006(5):671-675.(in Chinese)
[22]刘维俊,吉家俊,朱信龙,等.温敏性三元共聚水凝胶溶胀及消溶胀行为[J].高分子材料科学与工程,2012,28(2):32-35.LIU Weijun,JI Jiajun,ZHU Xinlong,et al.Swelling and deswelling behavior of temperature-sensitive terpolymer hydrogels[J].Polymer Materials Science and Engineering,2012,28(2):32-35.(in Chinese)
[23]周世海,蔡继业,陈勇.钙离子对海藻酸钠自组装行为影响的AFM研究[J].药物生物技术,2004,11(2):81-85.ZHOU Shihai,CAI Jiye,CHEN Yong.Effect of Ca2+on self-assembly films of sodium alginate studied by AFM[J].Pharmaceutical Biotechnology,2004,11(2):81-85.(in Chinese)