自拟加味酸枣仁汤治疗肝血亏虚型失眠的疗效观察
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摘要
目的研究自拟加味酸枣仁汤对失眠肝血亏虚证患者的疗效以及对匹兹堡睡眠质量指数(pittsburgh sleep quality index, PSQI)和失眠严重程度指数(insomnia severity index, ISI)评分的影响。方法将54例予常规治疗的肝血亏虚型失眠患者设为对照组,56例给予自拟加味酸枣仁汤治疗的失眠肝血亏虚证患者设为观察组,比较两组的PSQI、ISI、肝血亏虚证中医证候积分及临床疗效。结果治疗后,两组PSQI、ISI、中医证候积分较治疗前均显著降低,且观察组显著低于对照组(P<0.05或P<0.01)。观察组临床总有效率91.07%,明显高于对照组77.78%,差异具有统计学意义(P<0.05)。结论失眠肝血亏虚证患者采取自拟加味酸枣仁汤进行治疗,可显著改善睡眠质量,缓解失眠状态,从而提高临床疗效,促进患者早日康复。
Objective To investigate the curative efficacy of self-made Jiawei Suanzaoren Decoction on insomnia patients with liver-blood deficiency syndrome and its effects on Pittsburgh sleep quality index(PSQI) and insomnia severity index(ISI)score. Methods A total of 54 insomnia patients with liver-blood deficiency syndrome receiving the routine treatment were included into the control group and another 56 cases receiving self-made Jiawei Suanzaoren Decoction were included into the observation group. The PSQI, ISI, TCM syndrome score of liver-blood deficiency syndrome and clinical efficacy were compared between the two groups. Results After treatment, the PSQI, ISI and TCM syndrome score of the two groups were significantly decreased than before treatment, and the observation group was significantly lower than the control group(P<0.05 or P <0.01). The total effective rate of the observation group was 91.07%, which was significantly higher than 77.78% of the control group. The difference was statistically significant. Conclusion The self-made Jiawei Suanzaoren Decoction is an effective way to ameliorate the sleep quality and alleviate insomnia on insomnia patients with liver-blood deficiency syndrome, which can improve the clinical efficacy and early recovery.
Objective To investigate the curative efficacy of self-made Jiawei Suanzaoren Decoction on insomnia patients with liver-blood deficiency syndrome and its effects on Pittsburgh sleep quality index(PSQI) and insomnia severity index(ISI)score. Methods A total of 54 insomnia patients with liver-blood deficiency syndrome receiving the routine treatment were included into the control group and another 56 cases receiving self-made Jiawei Suanzaoren Decoction were included into the observation group. The PSQI, ISI, TCM syndrome score of liver-blood deficiency syndrome and clinical efficacy were compared between the two groups. Results After treatment, the PSQI, ISI and TCM syndrome score of the two groups were significantly decreased than before treatment, and the observation group was significantly lower than the control group(P<0.05 or P <0.01). The total effective rate of the observation group was 91.07%, which was significantly higher than 77.78% of the control group. The difference was statistically significant. Conclusion The self-made Jiawei Suanzaoren Decoction is an effective way to ameliorate the sleep quality and alleviate insomnia on insomnia patients with liver-blood deficiency syndrome, which can improve the clinical efficacy and early recovery.
引文
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[15]王桂彩,应森林.重用延胡索(元首汤、二胡汤)从肝论治顽固性失眠[J].实用中医内科杂志,2015,29(8):57-58.
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[2]禹琪,宋烨闻,衷敬柏.衷敬柏教授从气机失调论治失眠[J].吉林中医药,2014,34(4):347-349.
[3]杜捷,江琪,林燕.不寐病的中医诊治思路[J].中国临床医生杂志,2017,45(8):13-15.
[4]何丽玲,李云君.从肝藏血论治产后失眠[J].世界睡眠医学杂志,2016,3(1):35-36.
[5]中华医学会神经病学分会睡眠障碍学组.中国成人失眠诊断与治疗指南[J].中华神经科杂志,2012,45(7):534-540.
[6]朱文锋.中医诊断学[M].北京:中国医药科技出版社,2002:162-163,185.
[7] MOLLAYEVA T, THURAIRAJAH P, BURTON K, et al. The Pittsburgh sleep quality index as a screening tool for sleep dysfunction in clinical and non-clinical samples:A systematic review and meta-analysis.[J]. Sleep Medicine Reviews,2016,25(2):52-73.
[8] GERBER M, LANG C, LEMOLA S, et al. Validation of the German version of the insomnia severity index in adolescents,young adults and adult workers:results from three cross-sectional studies[J]. Bmc Psychiatry, 2016,16(1):1-14.
[9]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:380-383.
[10]张压西,向婷婷,王奕.加味酸枣仁汤治疗肝血亏虚证失眠患者60例临床观察[J].中医杂志,2013,54(9):750-753.
[11]刘頔,刘伟.从肝论治失眠验案3则[J].亚太传统医药,2017,13(6):87-88.
[12]张付民,冉仁国,赵宾宾.酸枣仁汤对慢性睡眠剥夺大鼠视交叉上核生物钟基因Clock和Bmal1表达的影响[J].湖南中医药大学学报,2019,39(1):19-22.
[13]俞婷婷,李伟平,丁志山.半夏的应用及毒性认识[J].现代中药研究与实践,2012,26(2):79-82.
[14]唐逸丰.延胡索化学成分与药理作用研究概况[J].中医临床研究,2018,10(23):144-146.
[15]王桂彩,应森林.重用延胡索(元首汤、二胡汤)从肝论治顽固性失眠[J].实用中医内科杂志,2015,29(8):57-58.
[16]曹景诚,梁茂新.基于文献分析的麦冬潜在功效探讨[J].中医杂志,2016,57(2):166-169.
[17]宋佳,闫晓凡.明代医家应用麦冬规律探讨[J].环球中医药,2016,9(7):851-853.
[18]许晓伍,陈群,郝木峰,等.夜交藤提取物对失眠大鼠额叶皮层神经元线粒体结构和功能的影响[J].广州中医药大学学报,2013,30(6):872-875.