血必净注射液灌注治疗膝关节骨性关节炎的疗效观察
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摘要
目的观察血必净注射液关节腔内灌注治疗膝关节骨性关节炎的疗效。方法选取海南省中医院骨科门诊2012年6月至2018年1月就诊的60例符合膝关节方面疾病的骨性关节炎(Ⅰ～Ⅱ)患者,按照就诊时间前后登记编号,根据编号的奇偶平均分为观察组和对照组,每组30例。观察组以血必净注射液进行膝关节腔内灌注治疗,单膝1次/5～6 d,4次为1个疗程;对照组选择玻璃酸钠注射治疗,每周1次,4次为1个疗程,共治疗3个疗程。随访6个月,分别比较治疗后1个月、3个月及6个月的有效率。结果 60例患者均成功完成6个月的随访。3个疗程治疗后,观察组患者的治疗总有效率96.7%,明显高于对照组的80.0%,差异有统计学意义(P<0.05);治疗3个月后随访,观察组患者的治疗总有效率为100.0%,略高于对照组的90.0%,但差异无统计学意义(P>0.05);治疗6个月后随访,观察组患者的治疗总有效率100.0%,也略高于对照组的93.3%,但差异无统计学意义(P>0.05)。结论血必净注射液关节腔内灌注治疗膝关节骨性关节炎疗效肯定,尤其近期疗效优于玻璃酸钠。
Objective To survey the curative effect of intra-articular perfusion of Xuebijing injection on knee osteoarthritis. Methods A total of 60 osteoarthritis(Ⅰ-Ⅱ) patients who met the knee disease were selected, who admitted to the Department of Orthopedics at Hainan Provincial Traditional Chinese Medicine Hospital from June 2012 to January 2018. After registering the number according to the visit time, they were divided into observation group and control group according to the number of parity, with 30 cases in each group. The observation group was treated with Xuebijing injection by intra-articular infusion of knee joints, once per knee for 5-6 days and four times for a course of treatment;and the control group received sodium hyaluronate injection, once a week and four times for a course of treatment. Both treatments lasted for a total of 3 courses. The followed-up duration were 6 months. The effective rates at 1 month, 3 months and 6 months after treatment were compared. Results All patients successfully completed 6 months of followed-up. After 3 courses of treatment, the total effective rate of treatment in the observation group was 96.7%, which was significantly higher than 80.0% in the control group(P<0.05). After 3 months of treatment, the total effective rate of the observation group was 100.0%, slightly higher than 90.0% of the control group(P>0.05). After 6 months of treatment, the total effective rate of the observation group was 100.0%, which was also slightly higher than 93.3% of the control group(P>0.05). Conclusion The curative effect of intra-articular perfusion of Xuebijing injection for the treatment of knee osteoarthritis is positive, especially its short-term efficacy is better than that of sodium hyaluronate.
Objective To survey the curative effect of intra-articular perfusion of Xuebijing injection on knee osteoarthritis. Methods A total of 60 osteoarthritis(Ⅰ-Ⅱ) patients who met the knee disease were selected, who admitted to the Department of Orthopedics at Hainan Provincial Traditional Chinese Medicine Hospital from June 2012 to January 2018. After registering the number according to the visit time, they were divided into observation group and control group according to the number of parity, with 30 cases in each group. The observation group was treated with Xuebijing injection by intra-articular infusion of knee joints, once per knee for 5-6 days and four times for a course of treatment;and the control group received sodium hyaluronate injection, once a week and four times for a course of treatment. Both treatments lasted for a total of 3 courses. The followed-up duration were 6 months. The effective rates at 1 month, 3 months and 6 months after treatment were compared. Results All patients successfully completed 6 months of followed-up. After 3 courses of treatment, the total effective rate of treatment in the observation group was 96.7%, which was significantly higher than 80.0% in the control group(P<0.05). After 3 months of treatment, the total effective rate of the observation group was 100.0%, slightly higher than 90.0% of the control group(P>0.05). After 6 months of treatment, the total effective rate of the observation group was 100.0%, which was also slightly higher than 93.3% of the control group(P>0.05). Conclusion The curative effect of intra-articular perfusion of Xuebijing injection for the treatment of knee osteoarthritis is positive, especially its short-term efficacy is better than that of sodium hyaluronate.
引文
[1]王开超. 411例膝关节骨性关节炎患者的流行病学调查分析[D].济南:山东中医药大学, 2015.
[2]中华医学会骨科分会.骨关节炎诊治指南(2007年版)[J].华骨科杂志, 2007, 27(10):793-796.
[3]郑筱萸.中医新药临床研究指导原则(试行)[M].北京:中国医药科技出版社, 2002:349-353.
[4]金凤羽.原发性膝骨性关节炎的非手术治疗[J].中国组织工程研究, 2013, 17(30):5531-5538.
[5]苗贵强,谭文成,吴昊,等.玻璃酸钠治疗中度膝关节骨性关节炎的远期疗效[J].暨南大学学报(医学版), 2011, 32(2):218-220.
[6]秋勋元,金檀林,李怫保.老年关节损伤与疾病学[M].北京:人民卫生出版杜, 1996:378.
[7]尹建平,何玉丽,王海燕,等.活血通络药饼结合扶元药饼治疗骨性关节炎的疗效观察[J].中国热带医学, 2006, 6(10):1854, 1861.
[8]杨敏.健步威风汤结合关节腔灌注治疗膝骨性关节炎临床观察[J].中国中医急症, 2012, 21(12):2015-2016.
[9]何华春,罗凯新,李珣莹.针刀治疗配合微量曲安奈德膝关节腔灌注治疗膝骨性关节炎的临床观察[J].中医临床研究, 2014, 6(1):43-44.
[10]赵志超,尤娟.针刺联合玻璃酸钠关节腔注射治疗膝关节骨关节炎临床疗效观察[J].辽宁中医药大学学报, 2018, 20(11):206-208.
[11]曹书华,王今达,李银平.从“菌毒并治”到“四证四法”-关于中西医结合治疗多器官功能障碍综合征辨证思路的深入与完善[J].中国危重病急救医学, 2005, 17(11):641-643.
[12]李娣,曹雪晓,蒲位凌,等.血必净注射液中有效成分的HPLC法定量检测[J].中国现代中药, 2018, 20(09):1157-1160.
[13]林道波,杨红莉,陈文腾,等.血必净对COPD急性加重期的疗效及凝血功能的影响[J].中国热带医学, 2009, 9(8):1514-1515.
[14]林道波,文俊珺,丁毅鹏,等.血必净治疗严重脓毒症40例的疗效观察[J].中国热带医学, 2009, 9(7):1286-1287.
[15]邝高艳,严可,柴爽,等.加味独活寄生合剂治疗膝骨关节炎临床疗效及对关节液中IL-1, IL-6, TNF-α及NO的影响[J].中国实验方剂学杂志, 2017, 23(01):174-178.
[16]翟云,高根德,徐守宇.膝关节骨关节炎的基础研究进展[J].中国骨伤, 2012, 25(1):83-87.
[17]田英.血必净注射液对全身炎症反应综合征患者体液免疫功能的调节作用[J].北方药学, 2018, 15(11):107-108.
[2]中华医学会骨科分会.骨关节炎诊治指南(2007年版)[J].华骨科杂志, 2007, 27(10):793-796.
[3]郑筱萸.中医新药临床研究指导原则(试行)[M].北京:中国医药科技出版社, 2002:349-353.
[4]金凤羽.原发性膝骨性关节炎的非手术治疗[J].中国组织工程研究, 2013, 17(30):5531-5538.
[5]苗贵强,谭文成,吴昊,等.玻璃酸钠治疗中度膝关节骨性关节炎的远期疗效[J].暨南大学学报(医学版), 2011, 32(2):218-220.
[6]秋勋元,金檀林,李怫保.老年关节损伤与疾病学[M].北京:人民卫生出版杜, 1996:378.
[7]尹建平,何玉丽,王海燕,等.活血通络药饼结合扶元药饼治疗骨性关节炎的疗效观察[J].中国热带医学, 2006, 6(10):1854, 1861.
[8]杨敏.健步威风汤结合关节腔灌注治疗膝骨性关节炎临床观察[J].中国中医急症, 2012, 21(12):2015-2016.
[9]何华春,罗凯新,李珣莹.针刀治疗配合微量曲安奈德膝关节腔灌注治疗膝骨性关节炎的临床观察[J].中医临床研究, 2014, 6(1):43-44.
[10]赵志超,尤娟.针刺联合玻璃酸钠关节腔注射治疗膝关节骨关节炎临床疗效观察[J].辽宁中医药大学学报, 2018, 20(11):206-208.
[11]曹书华,王今达,李银平.从“菌毒并治”到“四证四法”-关于中西医结合治疗多器官功能障碍综合征辨证思路的深入与完善[J].中国危重病急救医学, 2005, 17(11):641-643.
[12]李娣,曹雪晓,蒲位凌,等.血必净注射液中有效成分的HPLC法定量检测[J].中国现代中药, 2018, 20(09):1157-1160.
[13]林道波,杨红莉,陈文腾,等.血必净对COPD急性加重期的疗效及凝血功能的影响[J].中国热带医学, 2009, 9(8):1514-1515.
[14]林道波,文俊珺,丁毅鹏,等.血必净治疗严重脓毒症40例的疗效观察[J].中国热带医学, 2009, 9(7):1286-1287.
[15]邝高艳,严可,柴爽,等.加味独活寄生合剂治疗膝骨关节炎临床疗效及对关节液中IL-1, IL-6, TNF-α及NO的影响[J].中国实验方剂学杂志, 2017, 23(01):174-178.
[16]翟云,高根德,徐守宇.膝关节骨关节炎的基础研究进展[J].中国骨伤, 2012, 25(1):83-87.
[17]田英.血必净注射液对全身炎症反应综合征患者体液免疫功能的调节作用[J].北方药学, 2018, 15(11):107-108.