蛇床子提取液对离体蟾蜍坐骨神经动作电位的影响
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摘要
目的:研究蛇床子提取液对蟾蜍离体坐骨神经动作电位传导阻滞作用。方法:观察3种浓度蛇床子提取液(1g·ml-1、0.5g·ml-1、0.2g·ml-1)对蟾蜍离体坐骨神经复合动作电位的振幅和传导速度的影响。结果:3种浓度的蛇床子提取液均可使坐骨神经复合动作电位的振幅变小(P<0.01),传导速度变慢(P<0.01)并最终使坐骨神经动作电位消失。结论:蛇床子提取液能阻滞神经动作电位的传导。
Objective:To study the blockade effect of Cnidium monnieri(L.)cusson on action potential of sciatic nerve of toad.Methods:The influence of Cnidium monnieri(L.)cusson(1,0.5,0.2g·ml-1)on amplitude and conduction velocity of compound action potential of sciatic nerve of toad was observed in vitro.Results:The amplitude was markedly decreased(P<0.01)and the conduction velocity was significantly slowed down(P<0.01)by the decoction of Cnidium monnieri(L.)cussonin three different concentrations.The action potential of sciatic nerve vanished at last.Conclusion:Cnidium monnieri(L.)cussoncould block the conduction of action potential of nerve.
Objective:To study the blockade effect of Cnidium monnieri(L.)cusson on action potential of sciatic nerve of toad.Methods:The influence of Cnidium monnieri(L.)cusson(1,0.5,0.2g·ml-1)on amplitude and conduction velocity of compound action potential of sciatic nerve of toad was observed in vitro.Results:The amplitude was markedly decreased(P<0.01)and the conduction velocity was significantly slowed down(P<0.01)by the decoction of Cnidium monnieri(L.)cussonin three different concentrations.The action potential of sciatic nerve vanished at last.Conclusion:Cnidium monnieri(L.)cussoncould block the conduction of action potential of nerve.
引文
1 郑君,张昆,张成博.有毒中药蛇床子的本草学考证[J].山东中医药大学学报,2012,36(5):384-384.
2 连其深,上官珠,张志祖,等.蛇床子提取液的局部麻醉作用[J].中药通报,1988,13(9):552-554.
3 李旭伟,张俊清,罗露,等.辣椒碱对离体蟾蜍坐骨神经动作电位的影响[J].现代医药卫生,2011,28(7):979-980.
4 金曼,肖阳,李旭伟,等.四数九里香水提液对离体蟾蜍坐骨神经动作电位的影响[J].中国民族民间医药,2013,22(4):13-14.
5 张春梅,冯霞,钟艺.蛇床子的药理研究进展[J].实用药物与临床,2006,9(1):55-57.
6 向仁德,张新勇,韩英,等.中药蛇床子水提物活性成分的研究[J].中草药,1999,30(11):813-815.
7 张伟娜,胡玉红,张燕,等.中药蛇床子挥发油成分分析[J].黑龙江医药科学,2013,36(3):87-88.
8 王永辉,周然,李艳彦,等.蛇床子超临界提取物的皮肤毒理学研究[J].中国实验方剂学杂志,2007,13(12):38-41.
9 王永辉,张荣,冯玛莉,等.蛇床子超临界萃取物止痒作用的实验研究[J].山西中医学院学报,2005,6(2):17-18.
10 刘明平,吴依娜,韦品清,等.蛇床子止痒有效组分筛选及作用机制研究[J].中医药导报,2009,15(7):66-67.
2 连其深,上官珠,张志祖,等.蛇床子提取液的局部麻醉作用[J].中药通报,1988,13(9):552-554.
3 李旭伟,张俊清,罗露,等.辣椒碱对离体蟾蜍坐骨神经动作电位的影响[J].现代医药卫生,2011,28(7):979-980.
4 金曼,肖阳,李旭伟,等.四数九里香水提液对离体蟾蜍坐骨神经动作电位的影响[J].中国民族民间医药,2013,22(4):13-14.
5 张春梅,冯霞,钟艺.蛇床子的药理研究进展[J].实用药物与临床,2006,9(1):55-57.
6 向仁德,张新勇,韩英,等.中药蛇床子水提物活性成分的研究[J].中草药,1999,30(11):813-815.
7 张伟娜,胡玉红,张燕,等.中药蛇床子挥发油成分分析[J].黑龙江医药科学,2013,36(3):87-88.
8 王永辉,周然,李艳彦,等.蛇床子超临界提取物的皮肤毒理学研究[J].中国实验方剂学杂志,2007,13(12):38-41.
9 王永辉,张荣,冯玛莉,等.蛇床子超临界萃取物止痒作用的实验研究[J].山西中医学院学报,2005,6(2):17-18.
10 刘明平,吴依娜,韦品清,等.蛇床子止痒有效组分筛选及作用机制研究[J].中医药导报,2009,15(7):66-67.