高效液相色谱法串联质谱法测定化妆品用甜菜碱含量

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英文篇名：Determination of betaine content in cosmetics by HPLC-MS method 作者：邵泽辉 ; 曾莉 ; 闫世平 ; 张秀虹 ; 李腾 ; 林彬 ; 徐经纬 英文作者：SHAO Ze-hui;ZENG Li;YAN Shi-ping;ZHANG Xiu-hong;LI Teng;LIN Bin;XU Jing-wei;Guangzhou Analytical Center Branch Of Technology Development Company In Shantou Branch;Guangdong Institute Of Analysis, Guangdong Provincial Key Laboratory Of Emergency Test For Dangerous Chemicals, Guangdong Engineering And Technology Research Center For Ambient Mass Spectrometry; 关键词：化妆品用原料甜菜碱 ; 高效液相色谱串联质谱法 ; 实时直接分析质谱法 英文关键词：cosmetic raw betaine;;high performance liquid chromatography tandem mass spectrometry;;real-time direct analysis mass spectrometry 中文刊名：RYHX 英文刊名：Detergent & Cosmetics 机构：广州分析测试中心科力技术开发公司汕头分公司;广东省测试分析研究所广东省化学危害应急检测技术重点实验室广东省原位电离质谱分析工程技术研究中心; 出版日期：2018-02-25 出版单位：日用化学品科学 年：2018 期：v.41 基金：汕头市日用化学品专业镇协同创新中心建设项目(2016B090923011);; 广东省科学院FT-ICR-MS质谱分析技术创新平台建设专项(2017GDASCX-0104) 语种：中文; 页：RYHX201802006 页数：3 CN：02 ISSN：14-1210/TQ 分类号：26-28

摘要

通过高效液相色谱串联四级杆飞行时间质谱法(HPLC-Q-TOF-MS)和实时直接分析质谱法(DART-SVP)测定化妆品用原料甜菜碱的含量。结果表明,化妆品用原料甜菜碱和杂质进行了很好的分离,分离度大于1.369,线性范围为1~50μg/m L,平均相对标准差(RSD)为0.35%,回收率为98%~102%。通过对实际样品的检测,得到了实际样品中甜菜碱的含量为90.6%。
        The content of betaine in cosmetics was determined by HPLC-Q-TOF-MS and real-time direct analysis mass spectrometry(DART-SVP). The results showed that the raw material betaine and the impurities were well separated with the degree of separation being R> 1.369; The linear range was 1~ 50 μg/m L, the relative standard deviation(RSD) was 0.35% and the recovery rate was 98% ~ 102%. The content of betaine in the actual sample was determined to be 90.6% by detecting the actual sample.

引文

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