4D打印形状记忆聚合物在生物医疗领域的研究进展
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摘要
形状记忆聚合物是一种在外界刺激条件下产生形状变化的智能材料, 4D打印是基于可变形材料和3D打印技术的一种综合性技术,可变形材料中形状记忆聚合物的应用最为广泛,目前4D打印形状记忆聚合物在各个领域都有应用,尤其是在生物医疗领域具有巨大的应用价值. 4D打印技术突破了传统医学领域个性化订制的技术瓶颈,为生物医疗领域的进一步发展提供了新的契机.本文首先综述了形状记忆聚合物、3D打印技术以及4D打印形状记忆聚合物在生物医疗领域的国内外研究进展,并介绍了4D打印形状记忆聚合物在生物医疗领域的实例和应用价值,最后总结了4D打印形状记忆聚合物在生物医疗领域的应用前景、存在的问题以及未来的发展方向.
Shape memory polymers(SMPs) as a class of smart materials, can remember various shapes and return to their original shapes upon external stimuli. 4 D printing that is the combination of 3 D printing and SMPs has been used for fabrication of various SMPs in many areas of science and technology. At present, 4 D printing technology plays an important role and shows promising applications in biomedical field. 4 D printing breaks through the technical bottleneck of customization in traditional medical field and provides a new opportunity for the further development of biomedical field. In this article, we review the research progress of SMPs, 3 D printing technology and 4 D printed SMPs used in biomedical science. Moreover, we introduce some typical biomedical applications of 4 D printing of SMPs. Furthermore, we summary the application prospects, existing problems and future development direction of 4 D printed SMPs in biomedical field.
Shape memory polymers(SMPs) as a class of smart materials, can remember various shapes and return to their original shapes upon external stimuli. 4 D printing that is the combination of 3 D printing and SMPs has been used for fabrication of various SMPs in many areas of science and technology. At present, 4 D printing technology plays an important role and shows promising applications in biomedical field. 4 D printing breaks through the technical bottleneck of customization in traditional medical field and provides a new opportunity for the further development of biomedical field. In this article, we review the research progress of SMPs, 3 D printing technology and 4 D printed SMPs used in biomedical science. Moreover, we introduce some typical biomedical applications of 4 D printing of SMPs. Furthermore, we summary the application prospects, existing problems and future development direction of 4 D printed SMPs in biomedical field.
引文
1 Rodriguez J N, Zhu C, Duoss E B, et al. Shape-morphing composites with designed micro-architectures. Sci Rep, 2016, 6:27933
2 Behl M, Lendlein A. Shape-memory polymers. Mater Today, 2007, 10:20–28
3 Zhao Q, Qi H J, Xie T. Recent progress in shape memory polymer:New behavior, enabling materials, and mechanistic understanding. Prog Polymer Sci, 2015, 49-50:79–120
4 Hu J, Zhu Y, Huang H, et al. Recent advances in shape-memory polymers:Structure, mechanism, functionality, modeling and applications. Prog Polymer Sci, 2012, 37:1720–1763
5 魏洪秋,万雪,刘艳菊,等. 4D打印形状记忆聚合物材料的研究现状与应用前景.中国科学:技术科学, 2018, 48:2–16
6 Momeni F, Ni J. Nature-inspired smart solar concentrators by 4D printing. Renew Energy, 2018, 122:35–44
7 冷劲松,兰鑫,刘彦菊,等.形状记忆聚合物复合材料及其在空间可展开结构中的应用.宇航学报, 2010, 4:950–956
8 Lan X, Liu Y, Lv H, et al. Fiber reinforced shape-memory polymer composite and its application in a deployable hinge. Smart Mater Struct, 2009,18:024002
9 Lendlein A, Langer R. Biodegradable, elastic shape-memory polymers for potential biomedical applications. Science, 2002, 296:1673–1676
10 Lendlein A, Kelch S. Shape-memory polymers as stimuli-sensitive implant materials. Clin Hemorheol Micro, 2005, 32:105–116
11 Hardy J G, Palma M, Wind S J, et al. Responsive biomaterials:Advances in materials based on shape-memory polymers. Adv Mater, 2016, 28:5717–5724
12 Tibbits S. 4D Printing:Multi-material shape change. Archit Des, 2014, 84:116–121
13 Tibbits S. Printing products. 3D Print Add Manuf, 2016, 3:135
14 Leng J, Lan X, Liu Y, et al. Shape-memory polymers and their composites:Stimulus methods and applications. Prog Mater Sci, 2011, 56:1077–1135
15 Momeni F, Hassani N S M, Liu X, et al. A review of 4D printing. Mater Des, 2017, 122:42–79
16 Khoo Z X, Teoh J E M, Liu Y, et al. 3D printing of smart materials:A review on recent progresses in 4D printing. Virtual Phys Protot, 2015, 10:103 –122
17 Ge Q, Sakhaei A H, Lee H, et al. Multimaterial 4D printing with tailorable shape memory polymers. Sci Rep, 2016, 6:31110
18 Bodaghi M, Damanpack A R, Liao W H. Adaptive metamaterials by functionally graded 4D printing. Mater Des, 2017, 135:26–36
19 Leist S K, Zhou J. Current status of 4D printing technology and the potential of light-reactive smart materials as 4D printable materials. Virtual Phys Prototyp, 2016, 11:249–262
20 Shin D G, Kim T H, Kim D E. Review of 4D printing materials and their properties. Int J Precis Eng Manuf-Green Tech, 2017, 4:349–357
21 Lee A Y, An J, Chua C K. Two-way 4D printing:A review on the reversibility of 3D-printed shape memory materials. Engineering, 2017, 3:663–674
22 Choi J, Kwon O C, Jo W, et al. 4D printing technology:A review. 3D Print Add Manuf, 2015, 2:159–167
23 Bodaghi M, Damanpack A R, Liao W H. Triple shape memory polymers by 4D printing. Smart Mater Struct, 2018, 27:065010
24 Yang Y, Chen Y, Wei Y, et al. 3D printing of shape memory polymer for functional part fabrication. Int J Adv Manuf Technol, 2016, 84:2079–2095
25 Huang L, Jiang R, Wu J, et al. Ultrafast digital printing toward 4D shape changing materials. Adv Mater, 2017, 29:1605390
26 Ly S T, Kim J Y. 4D printing—Fused deposition modeling printing with thermal-responsive shape memory polymers. Int J Precis Eng ManufGreen Tech, 2017, 4:267–272
27 Miao S, Castro N, Nowicki M, et al. 4D printing of polymeric materials for tissue and organ regeneration. Mater Today, 2017, 20:577–591
28 Li X, Shang J, Wang Z. Intelligent materials:A review of applications in 4D printing. Assem Automat, 2017, 37:170–185
29 Bito J, Bahr R, Hester J, et al. Inkjet-/3D-/4D-printed autonomous wearable RF modules for biomonitoring, positioning and sensing applications.In:Proceedings Volume 10194, Micro-and Nanotechnology Sensors, Systems, and Applications IX. Anaheim, 2018. 10194
30 Naficy S, Gately R, Gorkin Iii R, et al. 4D printing of reversible shape morphing hydrogel structures. Macromol Mater Eng, 2017, 302:1600212
31 Monzón M D, Paz R, Pei E, et al. 4D printing:Processability and measurement of recovery force in shape memory polymers. Int J Adv Manuf Technol, 2017, 89:1827–1836
32 Pei E. 4D Printing:Dawn of an emerging technology cycle. Assem Automat, 2014, 34:310–314
33 Choong Y Y C, Maleksaeedi S, Eng H, et al. 4D printing of high performance shape memory polymer using stereolithography. Mater Des, 2017,126 :219–225
34 Wei H, Zhang Q, Yao Y, et al. Direct-write fabrication of 4D active shape-changing structures based on a shape memory polymer and its nanocomposite. ACS Appl Mater Interfaces, 2017, 9:876–883
35 Kuang X, Chen K, Dunn C K, et al. 3D printing of highly stretchable, shape-memory, and self-healing elastomer toward novel 4D printing. ACS Appl Mater Interfaces, 2018, 10:7381–7388
36 Morrison R J, Hollister S J, Niedner M F, et al. Mitigation of tracheobronchomalacia with 3D-printed personalized medical devices in pediatric patients. Sci Transl Med, 2015, 7:285ra64
37 Zarek M, Mansour N, Shapira S, et al. 4D printing of shape memory-based personalized endoluminal medical devices. Macromol Rapid Commun, 2017, 38:1600628
38 任伟锋,韩跃虎.第四军医大学西京医院4D打印技术打通生命通道.解放军报, 2016-09-26(002)
39 郭潇雅.镌刻时间的4D打印.中国医院院长, 2016, 9:40–41
40 Miao S, Zhu W, Castro N J, et al. 4D printing smart biomedical scaffolds with novel soybean oil epoxidized acrylate. Sci Rep, 2016, 6:27226
41 Hendrikson W J, Rouwkema J, Clementi F, et al. Towards 4D printed scaffolds for tissue engineering:exploiting 3D shape memory polymers to deliver time-controlled stimulus on cultured cells. Biofabrication, 2017, 9:031001
42 Miao S, Zhu W, Castro N J, et al. Four-dimensional printing hierarchy scaffolds with highly biocompatible smart polymers for tissue engineering applications. Tissue Eng Part C-Methods, 2016, 22:952–963
43 Senatov F S, Niaza K V, Zadorozhnyy M Y, et al. Mechanical properties and shape memory effect of 3D-printed PLA-based porous scaffolds. J Mech Behav Biomed Mater, 2016, 57:139–148
44 Senatov F S, Zadorozhnyy M Y, Niaza K V, et al. Shape memory effect in 3D-printed scaffolds for self-fitting implants. Eur Polymer J, 2017, 93:222 –231
45 Cabrera M S, Sanders B, Goor O J G M, et al. Computationally designed 3D printed self-expandable polymer stents with biodegradation capacity for minimally invasive heart valve implantation:A proof-of-concept study. 3D Print Add Manuf, 2017, 4:19–29
46 Yang C, Wang B, Li D, et al. Modelling and characterisation for the responsive performance of CF/PLA and CF/PEEK smart materials fabricated by 4D printing. Virtual Phys Protot, 2017, 12:69–76
47 韩宏.世界首例4D打印乳房重建手术成功.文汇报, 2017-06-17(005)
48 卢秉恒,李涤尘.增材制造(3D打印技术)发展.机械制造及其自动化, 2013, 4:1–4
49 Ge Q, Qi H J, Dunn M L. Active materials by four-dimension printing. Appl Phys Lett, 2013, 103:131901
50 Shaffer S, Yang K, Vargas J, et al. On reducing anisotropy in 3D printed polymers via ionizing radiation. Polymer, 2014, 55:5969–5979
51 Gladman A S, Matsumoto E A, Nuzzo R G, et al. Biomimetic 4D printing. Nat Mater, 2016, 15:413–418
2 Behl M, Lendlein A. Shape-memory polymers. Mater Today, 2007, 10:20–28
3 Zhao Q, Qi H J, Xie T. Recent progress in shape memory polymer:New behavior, enabling materials, and mechanistic understanding. Prog Polymer Sci, 2015, 49-50:79–120
4 Hu J, Zhu Y, Huang H, et al. Recent advances in shape-memory polymers:Structure, mechanism, functionality, modeling and applications. Prog Polymer Sci, 2012, 37:1720–1763
5 魏洪秋,万雪,刘艳菊,等. 4D打印形状记忆聚合物材料的研究现状与应用前景.中国科学:技术科学, 2018, 48:2–16
6 Momeni F, Ni J. Nature-inspired smart solar concentrators by 4D printing. Renew Energy, 2018, 122:35–44
7 冷劲松,兰鑫,刘彦菊,等.形状记忆聚合物复合材料及其在空间可展开结构中的应用.宇航学报, 2010, 4:950–956
8 Lan X, Liu Y, Lv H, et al. Fiber reinforced shape-memory polymer composite and its application in a deployable hinge. Smart Mater Struct, 2009,18:024002
9 Lendlein A, Langer R. Biodegradable, elastic shape-memory polymers for potential biomedical applications. Science, 2002, 296:1673–1676
10 Lendlein A, Kelch S. Shape-memory polymers as stimuli-sensitive implant materials. Clin Hemorheol Micro, 2005, 32:105–116
11 Hardy J G, Palma M, Wind S J, et al. Responsive biomaterials:Advances in materials based on shape-memory polymers. Adv Mater, 2016, 28:5717–5724
12 Tibbits S. 4D Printing:Multi-material shape change. Archit Des, 2014, 84:116–121
13 Tibbits S. Printing products. 3D Print Add Manuf, 2016, 3:135
14 Leng J, Lan X, Liu Y, et al. Shape-memory polymers and their composites:Stimulus methods and applications. Prog Mater Sci, 2011, 56:1077–1135
15 Momeni F, Hassani N S M, Liu X, et al. A review of 4D printing. Mater Des, 2017, 122:42–79
16 Khoo Z X, Teoh J E M, Liu Y, et al. 3D printing of smart materials:A review on recent progresses in 4D printing. Virtual Phys Protot, 2015, 10:103 –122
17 Ge Q, Sakhaei A H, Lee H, et al. Multimaterial 4D printing with tailorable shape memory polymers. Sci Rep, 2016, 6:31110
18 Bodaghi M, Damanpack A R, Liao W H. Adaptive metamaterials by functionally graded 4D printing. Mater Des, 2017, 135:26–36
19 Leist S K, Zhou J. Current status of 4D printing technology and the potential of light-reactive smart materials as 4D printable materials. Virtual Phys Prototyp, 2016, 11:249–262
20 Shin D G, Kim T H, Kim D E. Review of 4D printing materials and their properties. Int J Precis Eng Manuf-Green Tech, 2017, 4:349–357
21 Lee A Y, An J, Chua C K. Two-way 4D printing:A review on the reversibility of 3D-printed shape memory materials. Engineering, 2017, 3:663–674
22 Choi J, Kwon O C, Jo W, et al. 4D printing technology:A review. 3D Print Add Manuf, 2015, 2:159–167
23 Bodaghi M, Damanpack A R, Liao W H. Triple shape memory polymers by 4D printing. Smart Mater Struct, 2018, 27:065010
24 Yang Y, Chen Y, Wei Y, et al. 3D printing of shape memory polymer for functional part fabrication. Int J Adv Manuf Technol, 2016, 84:2079–2095
25 Huang L, Jiang R, Wu J, et al. Ultrafast digital printing toward 4D shape changing materials. Adv Mater, 2017, 29:1605390
26 Ly S T, Kim J Y. 4D printing—Fused deposition modeling printing with thermal-responsive shape memory polymers. Int J Precis Eng ManufGreen Tech, 2017, 4:267–272
27 Miao S, Castro N, Nowicki M, et al. 4D printing of polymeric materials for tissue and organ regeneration. Mater Today, 2017, 20:577–591
28 Li X, Shang J, Wang Z. Intelligent materials:A review of applications in 4D printing. Assem Automat, 2017, 37:170–185
29 Bito J, Bahr R, Hester J, et al. Inkjet-/3D-/4D-printed autonomous wearable RF modules for biomonitoring, positioning and sensing applications.In:Proceedings Volume 10194, Micro-and Nanotechnology Sensors, Systems, and Applications IX. Anaheim, 2018. 10194
30 Naficy S, Gately R, Gorkin Iii R, et al. 4D printing of reversible shape morphing hydrogel structures. Macromol Mater Eng, 2017, 302:1600212
31 Monzón M D, Paz R, Pei E, et al. 4D printing:Processability and measurement of recovery force in shape memory polymers. Int J Adv Manuf Technol, 2017, 89:1827–1836
32 Pei E. 4D Printing:Dawn of an emerging technology cycle. Assem Automat, 2014, 34:310–314
33 Choong Y Y C, Maleksaeedi S, Eng H, et al. 4D printing of high performance shape memory polymer using stereolithography. Mater Des, 2017,126 :219–225
34 Wei H, Zhang Q, Yao Y, et al. Direct-write fabrication of 4D active shape-changing structures based on a shape memory polymer and its nanocomposite. ACS Appl Mater Interfaces, 2017, 9:876–883
35 Kuang X, Chen K, Dunn C K, et al. 3D printing of highly stretchable, shape-memory, and self-healing elastomer toward novel 4D printing. ACS Appl Mater Interfaces, 2018, 10:7381–7388
36 Morrison R J, Hollister S J, Niedner M F, et al. Mitigation of tracheobronchomalacia with 3D-printed personalized medical devices in pediatric patients. Sci Transl Med, 2015, 7:285ra64
37 Zarek M, Mansour N, Shapira S, et al. 4D printing of shape memory-based personalized endoluminal medical devices. Macromol Rapid Commun, 2017, 38:1600628
38 任伟锋,韩跃虎.第四军医大学西京医院4D打印技术打通生命通道.解放军报, 2016-09-26(002)
39 郭潇雅.镌刻时间的4D打印.中国医院院长, 2016, 9:40–41
40 Miao S, Zhu W, Castro N J, et al. 4D printing smart biomedical scaffolds with novel soybean oil epoxidized acrylate. Sci Rep, 2016, 6:27226
41 Hendrikson W J, Rouwkema J, Clementi F, et al. Towards 4D printed scaffolds for tissue engineering:exploiting 3D shape memory polymers to deliver time-controlled stimulus on cultured cells. Biofabrication, 2017, 9:031001
42 Miao S, Zhu W, Castro N J, et al. Four-dimensional printing hierarchy scaffolds with highly biocompatible smart polymers for tissue engineering applications. Tissue Eng Part C-Methods, 2016, 22:952–963
43 Senatov F S, Niaza K V, Zadorozhnyy M Y, et al. Mechanical properties and shape memory effect of 3D-printed PLA-based porous scaffolds. J Mech Behav Biomed Mater, 2016, 57:139–148
44 Senatov F S, Zadorozhnyy M Y, Niaza K V, et al. Shape memory effect in 3D-printed scaffolds for self-fitting implants. Eur Polymer J, 2017, 93:222 –231
45 Cabrera M S, Sanders B, Goor O J G M, et al. Computationally designed 3D printed self-expandable polymer stents with biodegradation capacity for minimally invasive heart valve implantation:A proof-of-concept study. 3D Print Add Manuf, 2017, 4:19–29
46 Yang C, Wang B, Li D, et al. Modelling and characterisation for the responsive performance of CF/PLA and CF/PEEK smart materials fabricated by 4D printing. Virtual Phys Protot, 2017, 12:69–76
47 韩宏.世界首例4D打印乳房重建手术成功.文汇报, 2017-06-17(005)
48 卢秉恒,李涤尘.增材制造(3D打印技术)发展.机械制造及其自动化, 2013, 4:1–4
49 Ge Q, Qi H J, Dunn M L. Active materials by four-dimension printing. Appl Phys Lett, 2013, 103:131901
50 Shaffer S, Yang K, Vargas J, et al. On reducing anisotropy in 3D printed polymers via ionizing radiation. Polymer, 2014, 55:5969–5979
51 Gladman A S, Matsumoto E A, Nuzzo R G, et al. Biomimetic 4D printing. Nat Mater, 2016, 15:413–418