鱼腥草滴眼液治疗流行性角结膜炎的系统评价
|
摘要
目的系统评价鱼腥草滴眼液治疗流行性角结膜炎的有效性和安全性。方法计算机检索Cochrane Library、MEDLINE、EMBASE、PubMed、VIP、WanFang database、CNKI,并手工检索相关杂志,收集鱼腥草滴眼液治疗流行性角结膜炎的临床随机对照试验(RCT)。文献年限为1999年1月~2016年12月,检索英文及中文文献。按照纳入和排除标准,由两名评价员独立评价文献质量、提取资料并互相核对后,采用RevMan 5.3软件进行Meta分析。结果检索符合RCT纳入标准的鱼腥草滴眼液治疗流行性角结膜炎的随机对照试验论文共9篇,总共864例流行性角结膜炎患者。Meta分析结果显示:在有效率方面,鱼腥草滴眼液组优于化学药滴眼液组,2组差异有统计学意义[RR=1.20,95%CI(1.10,1.30),P<0.000 1];在显效率方面,鱼腥草滴眼液组优于化学药滴眼液组,2组差异有统计学意义[RR=1.27,95%CI(1.18,1.37),P<0.000 01];在治愈时间方面,鱼腥草滴眼液组治愈时间低于化学药滴眼液组,2组差异有统计学意义[MD=-3.53,95%CI(-3.85,-3.21),P<0.000 01]。结论初步研究显示,鱼腥草滴眼液治疗流行性角结膜炎在有效性方面明显优于对照组,但尚需更多高质量的临床对照研究加以证实。
Objective To systematically assess the clinical effectiveness and safety of Houttuynia eye drops in the treatment of epidemic keratoconjunctivitis.Methods We conducted electronic searching on the Cochrane Library,Medline,Embase,PubMed,VIP,WanFang database,CNKI to collect clinical randomized controlled trials of Houttuynia eye drops in the treatment of epidemic keratoconjunctivitis.We also handsearched some related journals.The literatures were limited from 1999 Jan.to 2016 Dec.in both Chinese and English.According to the inclusion and exclusion criteria,quality assessment and data extraction were conducted by two reviewers independently.Resolve differences through discussion and meta-analysis was performed using RevMan 5.3 software.Results Researching the randomized controlled trials that fit the RCTs inclusion criteria of Houttuynia eye drops in the treatment of epidemic keratoconjunctivitis was 9,total of 864 cases were enrolled.The results of meta-analysis showed that the effective rate of the Houttuynia eye drops group was significantly higher than that of the chemical medicine eye drops group.The difference between the 2 groups was statistically significant[RR=1.20,95%CI(1.10,1.30),P < 0.000 1];In terms of the markedly effective rate,Houttuynia eye drops group was significantly higher than the chemical medicine eye drops group,the difference between the 2groups was statistically significant[RR=1.27,95%CI(1.18,1.37),P < 0.000 01];In terms of cure time,Houttuynia eye drops group was significantly lower than the chemical medicine eye drops group,the difference between the 2groups was statistically significant[MD=-3.53,95%CI(-3.85,-3.21),P < 0.000 01].Conclusion Preliminary studies shows Houttuynia eye drops in the treatment of epidemic keratoconjunctivitis is better than that of control group,more high quality clinical studies are still required for further analysis.
Objective To systematically assess the clinical effectiveness and safety of Houttuynia eye drops in the treatment of epidemic keratoconjunctivitis.Methods We conducted electronic searching on the Cochrane Library,Medline,Embase,PubMed,VIP,WanFang database,CNKI to collect clinical randomized controlled trials of Houttuynia eye drops in the treatment of epidemic keratoconjunctivitis.We also handsearched some related journals.The literatures were limited from 1999 Jan.to 2016 Dec.in both Chinese and English.According to the inclusion and exclusion criteria,quality assessment and data extraction were conducted by two reviewers independently.Resolve differences through discussion and meta-analysis was performed using RevMan 5.3 software.Results Researching the randomized controlled trials that fit the RCTs inclusion criteria of Houttuynia eye drops in the treatment of epidemic keratoconjunctivitis was 9,total of 864 cases were enrolled.The results of meta-analysis showed that the effective rate of the Houttuynia eye drops group was significantly higher than that of the chemical medicine eye drops group.The difference between the 2 groups was statistically significant[RR=1.20,95%CI(1.10,1.30),P < 0.000 1];In terms of the markedly effective rate,Houttuynia eye drops group was significantly higher than the chemical medicine eye drops group,the difference between the 2groups was statistically significant[RR=1.27,95%CI(1.18,1.37),P < 0.000 01];In terms of cure time,Houttuynia eye drops group was significantly lower than the chemical medicine eye drops group,the difference between the 2groups was statistically significant[MD=-3.53,95%CI(-3.85,-3.21),P < 0.000 01].Conclusion Preliminary studies shows Houttuynia eye drops in the treatment of epidemic keratoconjunctivitis is better than that of control group,more high quality clinical studies are still required for further analysis.
引文
[1]赵堪兴,杨培增.眼科学[M].北京:人民卫生出版社,2008:95.
[2]石莹.鱼腥草注射液眼部超声雾化治疗流行性角膜结膜炎临床观察[J].中华实用中西医杂志,2003,9(3):1249-1250.
[3]涂良钰.中西医结合治疗眼科常见病[M].广州:广东人民出版社,1998:147-152.
[4]付智勇,洪惠,王艳玲.鱼腥草滴眼液治疗流行性角结膜炎疗效分析[J].实用医学杂志,2010,26(14):2673-2674.
[5]郑虎占,董泽宏,余清,主编.中药现代研究与应用(第三卷)[M].北京:学苑出版社,1998:2983-3003.
[6]祝建忠.鱼腥草注射液治疗小儿疱疹性咽峡炎62例[J].医药导报,2005,24(5):403.
[7]李国利,庄玉辉,那学明,等.3种中药对分支杆菌抗菌作用的研究[J].微生物学通报,1989;16(3):153-157.
[8]付智勇,洪惠,王艳玲.鱼腥草滴眼液治疗流行性角膜炎疗效分析[J].实用医学杂志,2010,26(14):2673-2674.
[9]夏竹青,董碧蓉.不同剂量美托洛尔治疗原发性高血压的疗效与安全性评价.中国循证医学杂志,2007,7(11):802-809.
[10]金涛,部留河,赵萌.鱼腥草滴眼液治疗流行性角膜结膜炎的临床观察[J].国际眼科杂志,2006,6(4):900-902.
[11]胡立志,张宏,叶茹珊,等.鱼腥草滴眼液和氧氟沙星滴眼液治疗流行性角膜结膜炎的对比观察[J].实用预防医学,2007,14(3):855-856.
[12]麦伟虎,孙有祖,张曼萍,等.鱼腥草滴眼液治疗流行性角结膜炎的疗效观察[J].中国热带医学,2011,11(4):496-497.
[13]罗建明.鱼腥草滴眼液治疗流行性角结膜炎的临床分析[J].中外医学研究,2011,9(17):128.
[14]曹地.鱼腥草滴眼液治疗流行性角结膜炎60例临床疗效观察[J].中国医药指南,2012,10(23):300-301.
[15]王凯.鱼腥草滴眼液治疗流行性角膜结膜炎疗效观察[J].中国误诊学杂志,2012,12(3):602-603.
[16]谢小青.加替沙星滴眼液与鱼腥草滴眼液治疗细菌性结膜炎的效果对比[J].中国当代医药,2013,20(34):109-110.
[17]朱娟芳.鱼腥草滴眼液与氧氟沙星滴眼液治疗流行性角结膜炎的对比研究[J].海峡药学,2013,25(2):144-145.
[18]王娟.鱼腥草滴眼液治疗急性细菌性结膜炎60例临床观察[J].中国社区医师,2015,31(32):83-85.
[2]石莹.鱼腥草注射液眼部超声雾化治疗流行性角膜结膜炎临床观察[J].中华实用中西医杂志,2003,9(3):1249-1250.
[3]涂良钰.中西医结合治疗眼科常见病[M].广州:广东人民出版社,1998:147-152.
[4]付智勇,洪惠,王艳玲.鱼腥草滴眼液治疗流行性角结膜炎疗效分析[J].实用医学杂志,2010,26(14):2673-2674.
[5]郑虎占,董泽宏,余清,主编.中药现代研究与应用(第三卷)[M].北京:学苑出版社,1998:2983-3003.
[6]祝建忠.鱼腥草注射液治疗小儿疱疹性咽峡炎62例[J].医药导报,2005,24(5):403.
[7]李国利,庄玉辉,那学明,等.3种中药对分支杆菌抗菌作用的研究[J].微生物学通报,1989;16(3):153-157.
[8]付智勇,洪惠,王艳玲.鱼腥草滴眼液治疗流行性角膜炎疗效分析[J].实用医学杂志,2010,26(14):2673-2674.
[9]夏竹青,董碧蓉.不同剂量美托洛尔治疗原发性高血压的疗效与安全性评价.中国循证医学杂志,2007,7(11):802-809.
[10]金涛,部留河,赵萌.鱼腥草滴眼液治疗流行性角膜结膜炎的临床观察[J].国际眼科杂志,2006,6(4):900-902.
[11]胡立志,张宏,叶茹珊,等.鱼腥草滴眼液和氧氟沙星滴眼液治疗流行性角膜结膜炎的对比观察[J].实用预防医学,2007,14(3):855-856.
[12]麦伟虎,孙有祖,张曼萍,等.鱼腥草滴眼液治疗流行性角结膜炎的疗效观察[J].中国热带医学,2011,11(4):496-497.
[13]罗建明.鱼腥草滴眼液治疗流行性角结膜炎的临床分析[J].中外医学研究,2011,9(17):128.
[14]曹地.鱼腥草滴眼液治疗流行性角结膜炎60例临床疗效观察[J].中国医药指南,2012,10(23):300-301.
[15]王凯.鱼腥草滴眼液治疗流行性角膜结膜炎疗效观察[J].中国误诊学杂志,2012,12(3):602-603.
[16]谢小青.加替沙星滴眼液与鱼腥草滴眼液治疗细菌性结膜炎的效果对比[J].中国当代医药,2013,20(34):109-110.
[17]朱娟芳.鱼腥草滴眼液与氧氟沙星滴眼液治疗流行性角结膜炎的对比研究[J].海峡药学,2013,25(2):144-145.
[18]王娟.鱼腥草滴眼液治疗急性细菌性结膜炎60例临床观察[J].中国社区医师,2015,31(32):83-85.