鱼腥草滴眼液治疗流行性角结膜炎疗效的Meta分析
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摘要
目的评价鱼腥草滴眼液治疗流行性角结膜炎的临床疗效。方法检索国内外数据库(中国知网,万方,维普,Pub Med和中国生物医学文献数据库),收集国内外已公开发表的有关鱼腥草滴眼液治疗流行性角结膜炎的临床疗效的随机对照试验,按Meta分析的要求对检索到的文献资料进行质量评估,采用Stata12.0对符合条件的研究进行Meta分析。结果初步筛选出相关文献共106篇,最终筛选并纳入研究的文献共14篇,总样本量879例。与对照组比较,鱼腥草滴眼液治疗流行性角结膜炎患者的总有效率OR合并值为2.49,95%CI(1.28,4.83),痊愈率OR合并值为2.11,95%CI(1.44,3.11),减轻患者异物感、流泪、睑结膜充血和睑结膜滤泡症状评分加权均数差(WMD)依次为:WMD=0.49,95%CI(0.37,0.61),P<0.001;WMD=0.26,95%CI(0.06,0.47),P=0.01;WMD=0.35,95%CI(0.21,0.50),P<0.001;WMD=0.28,95%CI(0.04,0.52),P=0.05。结论鱼腥草滴眼液治疗流行性角结膜炎的临床疗效优于西药对照组,但由于所纳入的研究均为低质量文献且数量有限,因此,仍需更严格设计的、大样本随机双盲对照试验的高质量研究来进一步验证和支持。
OBJECTIVE To evaluate the curative effect of Yuxingcao eye drops on epidemic keratoconjunctivitis by meta-analysis. METHODS All the studies were searched from China National Knowledge Infrastructure,Wanfang database, VIP database, Chinese biomedical literature database and Pub Med and were strictly evaluated through meta-analysis by Stata12.0 to assess the effect of Yuxingcao eye drops on epidemic keratoconjunctivitis.RESULTS A total of 106 related articles were selected by primary screening methods. By further screening, 14 studies including 879 cases were included and analyzed. Compared with the control group, the merged OR value of Yuxingcao eye drops on epidemic keratoconjunctivitis was 2.49, 95%CI(1.28, 4.83); the merged cure rate was 2.11,95%CI(1.44, 3.11); weighted mean difference(WMD) and statistical result of attenuation of symptom of foreign body sensation, tearing, palpebral conjunctiva congestion and palpebral conjunctiva follicular between two groups were WMD=0.49,95%CI(0.37,0.61), P<0.00001;WMD=0.26, 95%CI(0.06, 0.47), P=0.01; WMD=0.35,95%CI(0.21, 0.50), P <0.00001; WMD =0.28,95% CI(0.04, 0.52), P =0.05 respectively. CONCLUSIONS The result showed that the curative effects of Yuxingcao eye drops were better than that of the western medicine on epidemic keratoconjunctivitis. However, due to the low quality and limited number of literature, the conclusion from our re-search needed further validation from future studies with stricter design, higher quality, larger sample, and scheme of randomization, double-blind, placebo-control.
OBJECTIVE To evaluate the curative effect of Yuxingcao eye drops on epidemic keratoconjunctivitis by meta-analysis. METHODS All the studies were searched from China National Knowledge Infrastructure,Wanfang database, VIP database, Chinese biomedical literature database and Pub Med and were strictly evaluated through meta-analysis by Stata12.0 to assess the effect of Yuxingcao eye drops on epidemic keratoconjunctivitis.RESULTS A total of 106 related articles were selected by primary screening methods. By further screening, 14 studies including 879 cases were included and analyzed. Compared with the control group, the merged OR value of Yuxingcao eye drops on epidemic keratoconjunctivitis was 2.49, 95%CI(1.28, 4.83); the merged cure rate was 2.11,95%CI(1.44, 3.11); weighted mean difference(WMD) and statistical result of attenuation of symptom of foreign body sensation, tearing, palpebral conjunctiva congestion and palpebral conjunctiva follicular between two groups were WMD=0.49,95%CI(0.37,0.61), P<0.00001;WMD=0.26, 95%CI(0.06, 0.47), P=0.01; WMD=0.35,95%CI(0.21, 0.50), P <0.00001; WMD =0.28,95% CI(0.04, 0.52), P =0.05 respectively. CONCLUSIONS The result showed that the curative effects of Yuxingcao eye drops were better than that of the western medicine on epidemic keratoconjunctivitis. However, due to the low quality and limited number of literature, the conclusion from our re-search needed further validation from future studies with stricter design, higher quality, larger sample, and scheme of randomization, double-blind, placebo-control.
引文
[1]李娟,邵慧,钟正灵,等.鱼腥草抗菌作用研究进展[J].中国临床药理学与治疗学,2012,17(12):1427-1431.
[2]潘颖,魏亚超,王乐,等.鱼腥草滴眼液治疗流行性角结膜炎的临床疗效及经济效益学分析[J].现代药物与临床,2013,28(4):562-565.
[3]胡立志,张宏,叶茹珊,等.鱼腥草滴眼液和氧氟沙星滴眼液治疗流行性角膜结膜炎的对比观察[J].实用预防医学,2007,14(3):855-856.
[4]朱娟芳.鱼腥草滴眼液与氧氟沙星滴眼液治疗流行性角结膜炎的对比研究[J].海峡药学,2013,25(2):144-145.
[5]杨媚.鱼腥草滴眼液治疗流行性角结膜炎40例临床观察[J].中国民族民间医药,2015:31-33.
[6]曹地.鱼腥草滴眼液治疗流行性角结膜炎60例临床效果观察[J].中国医药指南,2012,10(23):300-301.
[7]麦伟虎,孙有祖,张曼萍,等.鱼腥草滴眼液治疗流行性角结膜炎的疗效观察[J].中国热带医学,2011,11(4):496-497.
[8]罗建明.鱼腥草滴眼液治疗流行性角结膜炎的临床分析[J].中外医学研究,2011,9(17):128.
[9]龚岚,孙兴怀.鱼腥草滴眼液治疗流行性角结膜炎的临床疗效观察[J].眼科新进展,2005,25(5):456-457.
[10]陈萌.鱼腥草滴眼液治疗流行性角结膜炎观察[J].实用中医药杂志,2007,23(1):51.
[11]焦瑞雪.鱼腥草滴眼液治疗流行性角结膜炎患者的临床效果观察和护理措施分析[J].辽宁中医药大学学报,2016,18(7):210-212.
[12]付智勇,洪惠,王艳玲.鱼腥草滴眼液治疗流行性角结膜炎疗效分析[J].实用医学杂志,2010,26(14):2673-2674.
[13]金涛,邹留河,赵萌.鱼腥草滴眼液治疗流行性角膜结膜炎的临床观察[J].国际眼科杂志,2006,6(4):900-902.
[14]王凯.鱼腥草滴眼液治疗流行性角膜结膜炎疗效观察[J].中国误诊学杂志,2012,12(3):602-603.
[15]李翔,王明芳,肖放,等.鱼腥草滴眼液治疗流行性角膜结膜炎临床总结[J].中国中医眼科杂志,2000,10(4):211-214.
[2]潘颖,魏亚超,王乐,等.鱼腥草滴眼液治疗流行性角结膜炎的临床疗效及经济效益学分析[J].现代药物与临床,2013,28(4):562-565.
[3]胡立志,张宏,叶茹珊,等.鱼腥草滴眼液和氧氟沙星滴眼液治疗流行性角膜结膜炎的对比观察[J].实用预防医学,2007,14(3):855-856.
[4]朱娟芳.鱼腥草滴眼液与氧氟沙星滴眼液治疗流行性角结膜炎的对比研究[J].海峡药学,2013,25(2):144-145.
[5]杨媚.鱼腥草滴眼液治疗流行性角结膜炎40例临床观察[J].中国民族民间医药,2015:31-33.
[6]曹地.鱼腥草滴眼液治疗流行性角结膜炎60例临床效果观察[J].中国医药指南,2012,10(23):300-301.
[7]麦伟虎,孙有祖,张曼萍,等.鱼腥草滴眼液治疗流行性角结膜炎的疗效观察[J].中国热带医学,2011,11(4):496-497.
[8]罗建明.鱼腥草滴眼液治疗流行性角结膜炎的临床分析[J].中外医学研究,2011,9(17):128.
[9]龚岚,孙兴怀.鱼腥草滴眼液治疗流行性角结膜炎的临床疗效观察[J].眼科新进展,2005,25(5):456-457.
[10]陈萌.鱼腥草滴眼液治疗流行性角结膜炎观察[J].实用中医药杂志,2007,23(1):51.
[11]焦瑞雪.鱼腥草滴眼液治疗流行性角结膜炎患者的临床效果观察和护理措施分析[J].辽宁中医药大学学报,2016,18(7):210-212.
[12]付智勇,洪惠,王艳玲.鱼腥草滴眼液治疗流行性角结膜炎疗效分析[J].实用医学杂志,2010,26(14):2673-2674.
[13]金涛,邹留河,赵萌.鱼腥草滴眼液治疗流行性角膜结膜炎的临床观察[J].国际眼科杂志,2006,6(4):900-902.
[14]王凯.鱼腥草滴眼液治疗流行性角膜结膜炎疗效观察[J].中国误诊学杂志,2012,12(3):602-603.
[15]李翔,王明芳,肖放,等.鱼腥草滴眼液治疗流行性角膜结膜炎临床总结[J].中国中医眼科杂志,2000,10(4):211-214.