幽门螺杆菌(Hp)感染与胃食管反流病的关系分析
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摘要
目的探讨幽门螺杆菌(Hp)感染与胃食管反流病的关系。方法选择本院2014年1月~2016年1月收治的胃食管反流病患者30例,其中正常5例、A级6例、B级9例、C级6例、D级4例,另外选择同期我院消化科经胃镜检查确诊的慢性胃炎伴糜烂患者30例,比较GERD组与胃炎组的Hp感染率以及不同分级GERD患者Hp感染率。结果 GERD组Hp感染率20.0%,胃炎组Hp感染率60.0%,两组比较差异有统计学意义(P<0.05)。GERD组中,正常级别患者的Hp感染率20.0%、A级患者的Hp感染率16.7%、B级患者的Hp感染率11.1%、C级患者的Hp感染率16.7%、D级患者的Hp感染率50.0%、不同分级GERD患者Hp感染率组间比较,差异不显著(P>0.05)。结论幽门螺杆菌(Hp)感染与胃食管反流病具有一定的相关性,Hp感染可能对GERD的发生可能起到一定的保护作用。但由于样本数较少,因此,仍需扩大样本数对Hp感染与GERD关系进行进一步研究,从而为胃食管反流病的临床治疗起到指导性作用。
Objective To investigate and analyze the relationship between helicobacter pylori(Hp) infection and gastroesophageal reflux disease. Methods 30 patients with gastroesophageal reflux disease who were admitted to our hospital from January 2014 to January 2016 were selected. There were 5 cases of normal, 6 cases of grade A, 5 cases of grade B, 6 cases of grade C, and 8 cases of grade D. In addition, 30 patients with chronic gastritis with erosion diagnosed by endoscopy in the Department of Gastroenterology in our hospital during the same period of time were selected.The Hp infection rate was compared between the GERD group and the gastritis group, and the Hp infection rate in the GERD patients with different grades was compared. Results The infection rate of Hp was 20.0% in GERD group and60.0% in gastritis group,there was significant difference between the two groups(P<0.05). In the GERD group, the Hp infection rate was 20.0% in normal patients, the Hp infection rate was 16.7% in the grade A patients, 11.1% in the grade B patients, 16.7% in the grade C patients, and 50.0% in the grade D patients. There was no significant difference in the Hp infection rate among different groups of GERD patients with different grades(P >0.05). Conclusion Helicobacter pylori(Hp) infection has a certain correlation with gastroesophageal reflux disease, and Hp infection may have a protective effect on the occurrence of GERD. However, due to the small number of samples, the number of samples should be expanded and further study on the relationship between Hp infection and GERD should be carried out, so as to provide a guiding significance for the clinical treatment of gastroesophageal reflux disease.
Objective To investigate and analyze the relationship between helicobacter pylori(Hp) infection and gastroesophageal reflux disease. Methods 30 patients with gastroesophageal reflux disease who were admitted to our hospital from January 2014 to January 2016 were selected. There were 5 cases of normal, 6 cases of grade A, 5 cases of grade B, 6 cases of grade C, and 8 cases of grade D. In addition, 30 patients with chronic gastritis with erosion diagnosed by endoscopy in the Department of Gastroenterology in our hospital during the same period of time were selected.The Hp infection rate was compared between the GERD group and the gastritis group, and the Hp infection rate in the GERD patients with different grades was compared. Results The infection rate of Hp was 20.0% in GERD group and60.0% in gastritis group,there was significant difference between the two groups(P<0.05). In the GERD group, the Hp infection rate was 20.0% in normal patients, the Hp infection rate was 16.7% in the grade A patients, 11.1% in the grade B patients, 16.7% in the grade C patients, and 50.0% in the grade D patients. There was no significant difference in the Hp infection rate among different groups of GERD patients with different grades(P >0.05). Conclusion Helicobacter pylori(Hp) infection has a certain correlation with gastroesophageal reflux disease, and Hp infection may have a protective effect on the occurrence of GERD. However, due to the small number of samples, the number of samples should be expanded and further study on the relationship between Hp infection and GERD should be carried out, so as to provide a guiding significance for the clinical treatment of gastroesophageal reflux disease.
引文
[1]石理华,刘乾,梁彦军,等.幽门螺杆菌及食管上下括约肌的压力与胃食管反流病的关系[J].当代医学,2013,19(16):149-150.
[2]向兴朝,田德安,刘梅.幽门螺杆菌感染与反流性食管炎的关系分析[J].内科急危重症杂志,2012,18(5):269-270.
[3]Pasechnikov VD,Chotchaeva AR.Effect of HP eradication on the development of gastroesophageal reflux disease:Results of the prospective study[J].Eksp Klin Gastroenterol,2011,(3):105-106.
[4]何亚非,郭红.幽门螺杆菌感染与胃食管反流病关系的研究现状[J].西南国防医药,2013,23(5):574-576.
[5]周政,刘有理,王光明,等.幽门螺杆菌感染与胃食管反流的关系[J].安徽医药,2013,17(3):436-437.
[6]詹志刚,王炘.幽门螺杆菌感染与胃食管反流病夜间酸突破的相关性探讨[J].临床消化病杂志,2013,25(1):36-38.
[7]高炳霞,段丽,王琨,等.幽门螺杆菌感染及胃炎类型与反流性食管炎关系的研究[J].中华医学杂志,2006,86(38):2674-2678.
[8]郭福勇.幽门螺杆菌感染与胃食管反流病的相关性研究[J].现代中西医结合杂志,2010,19(24):3064-3065
[9]陈秀英,沈洲立,鲁厚胜.幽门螺杆菌感染与胃食管反流病病程相关性研究[J].重庆医学,2014,43(8):913-914.
[10]于建兰,马艳梅,程荣贵.幽门螺杆菌感染与胃食管反流病关系探讨[J].长治医学院学报,2011,25(1):23-24.
[11]王木生,李玉芳,项文坤.根除幽门螺杆菌与胃食管反流病的关系[J].胃肠病学与肝病学杂志,2008,17(11):887-889.
[12]任建丽,刘建.幽门螺杆菌感染及相关性疾病的研究进展[J].医学综述,2013,19(7):1253-1254.
[13]尚品杰,柳静.幽门螺杆菌感染与胃食管反流病的相关性研究[J].中华医院感染学杂志,2014,24(18):4531-4532.
[14]Lundell L,Havu N,Miettinen P,et al.Changes of gastric mucosalarchitecture during long-term omeprazole therapy:results of a randomized clinical trial[J].Aliment Pharmacol Ther,2006,23:639-647.
[15]彭玄杰.幽门螺杆菌与胃食管反流病的关系[J].临床医学,2007,27(5):6-7.
[16]李常伟.根除幽门螺杆菌与胃食管反流病疗效间的关系研究[D].重庆医科大学,2015.
[2]向兴朝,田德安,刘梅.幽门螺杆菌感染与反流性食管炎的关系分析[J].内科急危重症杂志,2012,18(5):269-270.
[3]Pasechnikov VD,Chotchaeva AR.Effect of HP eradication on the development of gastroesophageal reflux disease:Results of the prospective study[J].Eksp Klin Gastroenterol,2011,(3):105-106.
[4]何亚非,郭红.幽门螺杆菌感染与胃食管反流病关系的研究现状[J].西南国防医药,2013,23(5):574-576.
[5]周政,刘有理,王光明,等.幽门螺杆菌感染与胃食管反流的关系[J].安徽医药,2013,17(3):436-437.
[6]詹志刚,王炘.幽门螺杆菌感染与胃食管反流病夜间酸突破的相关性探讨[J].临床消化病杂志,2013,25(1):36-38.
[7]高炳霞,段丽,王琨,等.幽门螺杆菌感染及胃炎类型与反流性食管炎关系的研究[J].中华医学杂志,2006,86(38):2674-2678.
[8]郭福勇.幽门螺杆菌感染与胃食管反流病的相关性研究[J].现代中西医结合杂志,2010,19(24):3064-3065
[9]陈秀英,沈洲立,鲁厚胜.幽门螺杆菌感染与胃食管反流病病程相关性研究[J].重庆医学,2014,43(8):913-914.
[10]于建兰,马艳梅,程荣贵.幽门螺杆菌感染与胃食管反流病关系探讨[J].长治医学院学报,2011,25(1):23-24.
[11]王木生,李玉芳,项文坤.根除幽门螺杆菌与胃食管反流病的关系[J].胃肠病学与肝病学杂志,2008,17(11):887-889.
[12]任建丽,刘建.幽门螺杆菌感染及相关性疾病的研究进展[J].医学综述,2013,19(7):1253-1254.
[13]尚品杰,柳静.幽门螺杆菌感染与胃食管反流病的相关性研究[J].中华医院感染学杂志,2014,24(18):4531-4532.
[14]Lundell L,Havu N,Miettinen P,et al.Changes of gastric mucosalarchitecture during long-term omeprazole therapy:results of a randomized clinical trial[J].Aliment Pharmacol Ther,2006,23:639-647.
[15]彭玄杰.幽门螺杆菌与胃食管反流病的关系[J].临床医学,2007,27(5):6-7.
[16]李常伟.根除幽门螺杆菌与胃食管反流病疗效间的关系研究[D].重庆医科大学,2015.