肺癌患者血清VEGF表达水平与临床病理特征的相关性研究
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摘要
目的探讨肺癌患者血清血管内皮生长因子(VEGF)表达水平变化与临床病理特征的关联性。方法选取昆明市延安医院肿瘤科2018年1-3月45例肺癌患者和35例健康者进行分析,入院后第2天晨起时抽取各组受检者空腹静脉血,以酶联免疫吸附测定(ELISA)血清VEGF水平,统计对比分析VEGF水平与分期、原发瘤大小、淋巴结转移之间的关系。结果肺癌患者血清中VEGF的表达:Ⅰ期与Ⅱ期之间差异无统计学意义(P>0.05);Ⅰ期与Ⅲ、Ⅳ期相比,差异有统计学意义(P<0.05);Ⅱ期与Ⅲ、Ⅳ期相比差异有统计学意义(P<0.05),Ⅲ期与Ⅳ期之间比较差异有统计学意义(P<0.05);T1和T2间比较差异无统计学意义(P>0.05),T1与T3、T4比较差异有统计学意义(P<0.05),T2分别与T3、T4比较差异有统计学意义(P<0.05),T3与T1、T2、T4比较差异有统计学意义(P<0.05);T4与T1、T2、T3比较差异有统计学意义(P<0.05);在N0与N1之间差异无统计学意义(P>0.05),N0和N2、N3之间差异有统计学意义(P<0.05),N1与N2、N3比较差异有统计学意义(P<0.05),N2与N3之间差异无统计学意义(P>0.05)。结论 VEGF随着肺癌患者的分期、原发肿瘤大小及淋巴结转移进展其血清中的表达水平升高。
Objective To investigate the relationship between the expression of serum vascular endothelial growth factor(VEGF)and clinicopathological features in patients with lung cancer.Methods A total of 45 patients with lung cancer and 35 healthy subjects from Jan 2018 to Mar 2018 in the department of oncology,Yan′an Hospital of Kunming City were enrolled.The fasting venous blood of each group was taken from the morning of the 2 nd day after admission.The serum VEGF level was determined by adsorption method,and the relationship between VEGF and stage,primary tumor size and lymph node metastasis was analyzed by statistical comparison.Results The expression of VEGF in serum of patients with lung cancer was not statistically different between stageⅠand stageⅡ(P>0.05).The statistical analysis of stageⅠcompared with stageⅢand stageⅣ was significant(P<0.05),and the statistics of stageⅡ compared with stageⅢ and stageⅣ.The analysis was meaningful(P<0.05),and the comparison between Ⅲ and Ⅳ was also meaningful;there was no statistical difference between T1 and T2(P>0.05),and there was statistical difference between T1 and T3,T4(P<0.05).There was a statistically significant difference between T2 and T3,T4(P<0.05).There was significant difference between T3 and T1,T2 and T4(P<0.05).There was significant difference between T4 and T1,T2 and T3(P<0.05).There was no statistical difference between N0 and N1(P>0.05),and there was a statistical difference between N0 and N2,N3(P<0.05).There was also a statistical difference between N1 and N2,N3(P<0.05).Between N2 and N3,there was no statistical difference(P>0.05).Conclusion The expression of VEGF in serum is increased with the stage,primary tumor size and lymph node metastasis of lung cancer patients.
Objective To investigate the relationship between the expression of serum vascular endothelial growth factor(VEGF)and clinicopathological features in patients with lung cancer.Methods A total of 45 patients with lung cancer and 35 healthy subjects from Jan 2018 to Mar 2018 in the department of oncology,Yan′an Hospital of Kunming City were enrolled.The fasting venous blood of each group was taken from the morning of the 2 nd day after admission.The serum VEGF level was determined by adsorption method,and the relationship between VEGF and stage,primary tumor size and lymph node metastasis was analyzed by statistical comparison.Results The expression of VEGF in serum of patients with lung cancer was not statistically different between stageⅠand stageⅡ(P>0.05).The statistical analysis of stageⅠcompared with stageⅢand stageⅣ was significant(P<0.05),and the statistics of stageⅡ compared with stageⅢ and stageⅣ.The analysis was meaningful(P<0.05),and the comparison between Ⅲ and Ⅳ was also meaningful;there was no statistical difference between T1 and T2(P>0.05),and there was statistical difference between T1 and T3,T4(P<0.05).There was a statistically significant difference between T2 and T3,T4(P<0.05).There was significant difference between T3 and T1,T2 and T4(P<0.05).There was significant difference between T4 and T1,T2 and T3(P<0.05).There was no statistical difference between N0 and N1(P>0.05),and there was a statistical difference between N0 and N2,N3(P<0.05).There was also a statistical difference between N1 and N2,N3(P<0.05).Between N2 and N3,there was no statistical difference(P>0.05).Conclusion The expression of VEGF in serum is increased with the stage,primary tumor size and lymph node metastasis of lung cancer patients.
引文
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[6]顾磊,文斐,肖婕.PTTG、VEGF-C的表达以及表皮生长因子受体基因突变与非小细胞肺癌临床病理特征和预后之间的关系[J].临床和实验医学杂志,2018,17(7):739-743.
[7]顾金花,陈玲,周丽娜,等.血清VEGF,SCC-Ag和CY-FRA21-1对中晚期肺鳞癌化疗疗效评估的价值[J].现代检验医学杂志,2014,29(5):123-126.
[8]FONTANINI G,BOLDRINI L,VIGNATI S,et al.607Vascular endothelial growth factor(VEGF)in non small cell lung carcinomas(NSCLC):Prognostic implications[J].Lung Cancer,1997(18):156-160.
[9]唐静,夏婧,张湘燕.非小细胞肺癌患者血清HIF-1α、MMP-2和VEGF的检测及其与临床特征的关系[J].临床合理用药杂志,2018,11(10):18-19.
[10]韩忠,吴文川,李华,等.非小细胞肺癌组织中VEGF、P-ACC、LKB1表达变化与微血管密度的关系[J].山东医药,2018,58(34):41-43.
[2]刘刚,李源.血管内皮生长因子与肿瘤生长的关系[J].解放军医学院学报,2010,31(1):93-94.
[3]FERRARA N,GERBER H P,LECOUTER J.The biology of VEGF and its receptors[J].Nature Med,2003,9(6):669-676.
[4]MATSUYAMA W,HASHIGUCHI T,MIZOGUCHI A,et al.Serum levels of vascular endothelial growth factor dependent on the stage progression of lung cancer[J].Chest,2000,118(4):948-951.
[5]彭华斌,冯华松.血清CEA、VEGF水平变化对非小细胞肺癌患者TNM分期的判定价值[J].中国卫生工程学,2018,17(3):388-390.
[6]顾磊,文斐,肖婕.PTTG、VEGF-C的表达以及表皮生长因子受体基因突变与非小细胞肺癌临床病理特征和预后之间的关系[J].临床和实验医学杂志,2018,17(7):739-743.
[7]顾金花,陈玲,周丽娜,等.血清VEGF,SCC-Ag和CY-FRA21-1对中晚期肺鳞癌化疗疗效评估的价值[J].现代检验医学杂志,2014,29(5):123-126.
[8]FONTANINI G,BOLDRINI L,VIGNATI S,et al.607Vascular endothelial growth factor(VEGF)in non small cell lung carcinomas(NSCLC):Prognostic implications[J].Lung Cancer,1997(18):156-160.
[9]唐静,夏婧,张湘燕.非小细胞肺癌患者血清HIF-1α、MMP-2和VEGF的检测及其与临床特征的关系[J].临床合理用药杂志,2018,11(10):18-19.
[10]韩忠,吴文川,李华,等.非小细胞肺癌组织中VEGF、P-ACC、LKB1表达变化与微血管密度的关系[J].山东医药,2018,58(34):41-43.